Guest Lecture: Cancer Immunity Microenvironment
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Questions and Answers

What is the role of Type 1 Interferons in immune responses?

  • Cause immune suppression (correct)
  • Induce positive immune response
  • Enhance autoimmune diseases
  • Promote allergy reactions
  • In the context of the text, what is the action of PD1 induced by Type 1 Interferons?

  • Promote cell growth
  • Activate apoptosis
  • Enhance DNA repair
  • Inhibit immune response (correct)
  • Which type of cells can Type 1 Interferons act on?

  • Any nucleated cell type (correct)
  • Only red blood cells
  • Only muscle cells
  • Only platelets
  • What is the significance of mRNA splicing in B cells?

    <p>Decides if B cells are secreted or membrane-bound</p> Signup and view all the answers

    How do Type 1 Interferons promote resistance to therapy?

    <p>By inducing negative immune suppression</p> Signup and view all the answers

    What is the main outcome of prolonged Type 1 Interferon response?

    <p>Negative immune suppression</p> Signup and view all the answers

    What is the purpose of immune surveillance in cancer immunity?

    <p>To recognize and eliminate transformed cells</p> Signup and view all the answers

    Which molecules are targeted in Immune Checkpoint Inhibition therapy?

    <p>CTLA4 and PD1</p> Signup and view all the answers

    What is the main function of PD1 in T cells?

    <p>Signal T cells to die</p> Signup and view all the answers

    What makes excluded (cold) tumors easier to treat compared to inflamed (hot) tumors?

    <p>Inability of immune cells to infiltrate</p> Signup and view all the answers

    Why is mass cytometry important in cancer research?

    <p>To identify novel biomarkers and therapeutic targets</p> Signup and view all the answers

    What is the role of CTLA4 in T cell activation?

    <p>Induce inhibitory signaling</p> Signup and view all the answers

    What is a characteristic of tertiary lymph node structure (TLS) tumors?

    <p>They form at the edge of the tumor</p> Signup and view all the answers

    Which strategy aims to enhance the endogenous immune response to cancer?

    <p>Immunotherapy targeting PD1 and CTLA4</p> Signup and view all the answers

    What distinguishes inflamed (hot) tumors from excluded (cold) tumors?

    <p>Immune cells can infiltrate hot tumors.</p> Signup and view all the answers

    What factor contributed to the success of immunotherapy in cancer treatment?

    <p>Increased clinical trials in the 2000s.</p> Signup and view all the answers

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