Guest Lecture: Cancer Immunity Microenvironment

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What is the role of Type 1 Interferons in immune responses?

Cause immune suppression (correct)

Induce positive immune response

Enhance autoimmune diseases

Promote allergy reactions

In the context of the text, what is the action of PD1 induced by Type 1 Interferons?

Promote cell growth

Activate apoptosis

Enhance DNA repair

Inhibit immune response (correct)

Which type of cells can Type 1 Interferons act on?

Any nucleated cell type (correct)

Only red blood cells

Only muscle cells

Only platelets

What is the significance of mRNA splicing in B cells?

Decides if B cells are secreted or membrane-bound Signup and view all the answers

How do Type 1 Interferons promote resistance to therapy?

By inducing negative immune suppression Signup and view all the answers

What is the main outcome of prolonged Type 1 Interferon response?

Negative immune suppression Signup and view all the answers

What is the purpose of immune surveillance in cancer immunity?

To recognize and eliminate transformed cells Signup and view all the answers

Which molecules are targeted in Immune Checkpoint Inhibition therapy?

CTLA4 and PD1 Signup and view all the answers

What is the main function of PD1 in T cells?

Signal T cells to die Signup and view all the answers

What makes excluded (cold) tumors easier to treat compared to inflamed (hot) tumors?

Inability of immune cells to infiltrate Signup and view all the answers

Why is mass cytometry important in cancer research?

To identify novel biomarkers and therapeutic targets Signup and view all the answers

What is the role of CTLA4 in T cell activation?

Induce inhibitory signaling Signup and view all the answers

What is a characteristic of tertiary lymph node structure (TLS) tumors?

They form at the edge of the tumor Signup and view all the answers

Which strategy aims to enhance the endogenous immune response to cancer?

Immunotherapy targeting PD1 and CTLA4 Signup and view all the answers

What distinguishes inflamed (hot) tumors from excluded (cold) tumors?

Immune cells can infiltrate hot tumors. Signup and view all the answers

What factor contributed to the success of immunotherapy in cancer treatment?

Increased clinical trials in the 2000s. Signup and view all the answers