16 Questions
What is the role of Type 1 Interferons in immune responses?
Cause immune suppression
In the context of the text, what is the action of PD1 induced by Type 1 Interferons?
Inhibit immune response
Which type of cells can Type 1 Interferons act on?
Any nucleated cell type
What is the significance of mRNA splicing in B cells?
Decides if B cells are secreted or membrane-bound
How do Type 1 Interferons promote resistance to therapy?
By inducing negative immune suppression
What is the main outcome of prolonged Type 1 Interferon response?
Negative immune suppression
What is the purpose of immune surveillance in cancer immunity?
To recognize and eliminate transformed cells
Which molecules are targeted in Immune Checkpoint Inhibition therapy?
CTLA4 and PD1
What is the main function of PD1 in T cells?
Signal T cells to die
What makes excluded (cold) tumors easier to treat compared to inflamed (hot) tumors?
Inability of immune cells to infiltrate
Why is mass cytometry important in cancer research?
To identify novel biomarkers and therapeutic targets
What is the role of CTLA4 in T cell activation?
Induce inhibitory signaling
What is a characteristic of tertiary lymph node structure (TLS) tumors?
They form at the edge of the tumor
Which strategy aims to enhance the endogenous immune response to cancer?
Immunotherapy targeting PD1 and CTLA4
What distinguishes inflamed (hot) tumors from excluded (cold) tumors?
Immune cells can infiltrate hot tumors.
What factor contributed to the success of immunotherapy in cancer treatment?
Increased clinical trials in the 2000s.
Explore the concepts of immune surveillance, immune evasion, anti-tumor immunity, and tumor escape in the context of cancer. Learn about the evolving interactions between the immune system and cancer cells and how we can potentially harness the immune system to eliminate cancers.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
