Cancer Health Risk Assessment Lecture 5
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Cancer Health Risk Assessment Lecture 5

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Questions and Answers

What is the formula used to calculate the lifetime average daily dose associated with inhalation (LADDinh)?

LADDinh = (Cg * ET * EF * InhR) / (BW * ATcar * cf)

What is the unit of measurement for the particulate phase concentration of each individual PAH (Cp)?

µg/g

What is the purpose of the incremental lifetime cancer risk (ILTCRi) in assessing PAH exposure?

To estimate the increased risk of cancer due to exposure to PAHs through a particular route (i).

What is the dermal adsorption fraction (ABS) in the context of PAH exposure?

<p>A dimensionless value representing the fraction of PAHs that is absorbed through the skin.</p> Signup and view all the answers

What is the unit of measurement for the skin surface area exposed (SA)?

<p>cm²</p> Signup and view all the answers

What is the purpose of the cancer slope factor (CSFi) in assessing PAH exposure?

<p>To quantify the strength of the relationship between PAH exposure and cancer risk.</p> Signup and view all the answers

What is the purpose of using Relative Potency Factors (RPF) in assessing the health risk posed by exposure to multi-component PAHs?

<p>To connect various PAHs to benzo[a]pyrene, allowing for the combining of adverse effects accompanied by concurrent exposure to several individual PAHs.</p> Signup and view all the answers

How is the B[a]P equivalent concentration (B[a]Peq) calculated?

<p>By multiplying the individual PAH concentration by its RPF.</p> Signup and view all the answers

What is the equation used to convert PAH concentrations into BaP 'equivalent' concentrations?

<p>=∑[𝑃𝐴𝐻]𝑖 × 𝑅𝑃𝐹𝑖</p> Signup and view all the answers

What routes are considered in calculating the Incremental Lifetime Cancer Risk (ILCR) of PAHs attached to suspended particulates?

<p>Ingestion and dermal routes.</p> Signup and view all the answers

Why are RPF values based on tumor bioassay data?

<p>Because the dose-response data for BaP are well studied.</p> Signup and view all the answers

What is the ultimate goal of calculating the B[a]Peq and ILCR?

<p>To determine the cancer risk assessment.</p> Signup and view all the answers

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