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Cancer Health Risk Assessment Lecture 5

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Questions and Answers

What is the formula used to calculate the lifetime average daily dose associated with inhalation (LADDinh)?

LADDinh = (Cg * ET * EF * InhR) / (BW * ATcar * cf)

What is the unit of measurement for the particulate phase concentration of each individual PAH (Cp)?

µg/g

What is the purpose of the incremental lifetime cancer risk (ILTCRi) in assessing PAH exposure?

To estimate the increased risk of cancer due to exposure to PAHs through a particular route (i).

What is the dermal adsorption fraction (ABS) in the context of PAH exposure?

A dimensionless value representing the fraction of PAHs that is absorbed through the skin. Signup and view all the answers

What is the unit of measurement for the skin surface area exposed (SA)?

cm² Signup and view all the answers

What is the purpose of the cancer slope factor (CSFi) in assessing PAH exposure?

To quantify the strength of the relationship between PAH exposure and cancer risk. Signup and view all the answers

What is the purpose of using Relative Potency Factors (RPF) in assessing the health risk posed by exposure to multi-component PAHs?

To connect various PAHs to benzo[a]pyrene, allowing for the combining of adverse effects accompanied by concurrent exposure to several individual PAHs. Signup and view all the answers

How is the B[a]P equivalent concentration (B[a]Peq) calculated?

By multiplying the individual PAH concentration by its RPF. Signup and view all the answers

What is the equation used to convert PAH concentrations into BaP 'equivalent' concentrations?

=∑[𝑃𝐴𝐻]𝑖 × 𝑅𝑃𝐹𝑖 Signup and view all the answers

What routes are considered in calculating the Incremental Lifetime Cancer Risk (ILCR) of PAHs attached to suspended particulates?

Ingestion and dermal routes. Signup and view all the answers

Why are RPF values based on tumor bioassay data?

Because the dose-response data for BaP are well studied. Signup and view all the answers

What is the ultimate goal of calculating the B[a]Peq and ILCR?

To determine the cancer risk assessment. Signup and view all the answers