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Hairy Cell Leukemia Quiz

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Questions and Answers

What is the characteristic appearance of cells in hairy cell leukemia (HCL)?

Round nuclei and densely granulated cytoplasm

Thick and irregular nuclei with smooth cytoplasm

Ovaloid nuclei and finely 'fraying' cytoplasm (correct)

Long and spindle-shaped nuclei with vacuolated cytoplasm

What are the distinguishing features of hairy cell leukemia variant (HCL-V) compared to classic HCL?

HCL-V affects younger individuals, while classic HCL is more common in older individuals

HCL-V primarily affects the bone marrow, while classic HCL affects both the blood and bone marrow

HCL-V presents with more aggressive symptoms, while classic HCL is often asymptomatic

HCL-V is more evenly divided between males and females, while classic HCL primarily affects men (correct)

Which symptom is commonly associated with hairy cell leukemia (HCL)?

Persistent cough and shortness of breath

Excessive sweating, especially at night (correct)

Visual disturbances and sudden loss of vision

Severe abdominal pain and bloating

During a physical exam for hairy cell leukemia (HCL), what may the doctor be able to feel?

<p>A swollen spleen or liver</p> Signup and view all the answers

What makes up approximately 2% of all leukemias?

<p>Hairy cell leukemia (HCL)</p> Signup and view all the answers

Study Notes

Hairy Cell Leukemia (HCL) Characteristics

Cells exhibit a distinct "hairy" appearance due to fine cytoplasmic projections.
The characteristic morphology is observed under a microscope, often showing irregularly shaped nuclei.

Hairy Cell Leukemia Variant (HCL-V) Features

HCL-V lacks some typical features of classic HCL, including less pronounced "hairy" projections.
Patients with HCL-V generally present with more aggressive disease and may not respond as well to standard therapies used for classic HCL.

Common Symptoms of HCL

A common symptom associated with hairy cell leukemia is splenomegaly, or enlargement of the spleen.

Physical Exam Findings for HCL

During a physical examination, a doctor may palpate an enlarged spleen, which is often felt in patients with HCL.

Leukemia Statistics

Hairy cell leukemia accounts for approximately 2% of all leukemias diagnosed.

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Description

Test your knowledge about hairy cell leukemia, a rare cancer of B cells that affects blood counts and bone marrow. Learn about the unique appearance of the cells under the microscope and its classification as a sub-type of chronic lymphoid leukemia.