Hairy Cell Leukemia Quiz

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Questions and Answers

What is the characteristic appearance of cells in hairy cell leukemia (HCL)?

  • Round nuclei and densely granulated cytoplasm
  • Thick and irregular nuclei with smooth cytoplasm
  • Ovaloid nuclei and finely 'fraying' cytoplasm (correct)
  • Long and spindle-shaped nuclei with vacuolated cytoplasm

What are the distinguishing features of hairy cell leukemia variant (HCL-V) compared to classic HCL?

  • HCL-V affects younger individuals, while classic HCL is more common in older individuals
  • HCL-V primarily affects the bone marrow, while classic HCL affects both the blood and bone marrow
  • HCL-V presents with more aggressive symptoms, while classic HCL is often asymptomatic
  • HCL-V is more evenly divided between males and females, while classic HCL primarily affects men (correct)

Which symptom is commonly associated with hairy cell leukemia (HCL)?

  • Persistent cough and shortness of breath
  • Excessive sweating, especially at night (correct)
  • Visual disturbances and sudden loss of vision
  • Severe abdominal pain and bloating

During a physical exam for hairy cell leukemia (HCL), what may the doctor be able to feel?

<p>A swollen spleen or liver (C)</p> Signup and view all the answers

What makes up approximately 2% of all leukemias?

<p>Hairy cell leukemia (HCL) (B)</p> Signup and view all the answers

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Study Notes

Hairy Cell Leukemia (HCL) Characteristics

  • Cells exhibit a distinct "hairy" appearance due to fine cytoplasmic projections.
  • The characteristic morphology is observed under a microscope, often showing irregularly shaped nuclei.

Hairy Cell Leukemia Variant (HCL-V) Features

  • HCL-V lacks some typical features of classic HCL, including less pronounced "hairy" projections.
  • Patients with HCL-V generally present with more aggressive disease and may not respond as well to standard therapies used for classic HCL.

Common Symptoms of HCL

  • A common symptom associated with hairy cell leukemia is splenomegaly, or enlargement of the spleen.

Physical Exam Findings for HCL

  • During a physical examination, a doctor may palpate an enlarged spleen, which is often felt in patients with HCL.

Leukemia Statistics

  • Hairy cell leukemia accounts for approximately 2% of all leukemias diagnosed.

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