Cancer Chemotherapeutic Agents Lecture 4 - Dr. M Casely-Hayford: Antimetabolites
22 Questions
0 Views

Cancer Chemotherapeutic Agents Lecture 4 - Dr. M Casely-Hayford: Antimetabolites

Created by
@RefreshingSkunk

Podcast Beta

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following enzymes is NOT essential for DNA synthesis?

  • DNA polymerase
  • Thymidylate synthase
  • RNA polymerase (correct)
  • DNA ligase
  • Which of the following mechanisms does NOT describe the action of antimetabolites?

  • Arrest of DNA chain elongation
  • Promotion of nucleotide incorporation into growing DNA strand
  • Inhibition of enzymes involved in DNA synthesis
  • Inhibition of RNA function (correct)
  • Which of the following is NOT a common side effect of antimetabolite treatment?

  • Gastrointestinal toxicity
  • Neurotoxicity (correct)
  • Myelosuppression
  • Alopecia
  • Which of the following B vitamins is NOT involved in DNA synthesis?

    <p>Vitamin B5 (Pantothenic acid)</p> Signup and view all the answers

    Which of the following is NOT a reason for using antimetabolites in cancer treatment?

    <p>High selectivity for cancer cells</p> Signup and view all the answers

    Which of the following is NOT a risk factor for folate deficiency?

    <p>Hyperthyroidism</p> Signup and view all the answers

    Which compound acts as a one carbon source for dTMP synthesis?

    <p>N5, N10-methylene FH4</p> Signup and view all the answers

    Which drug is a potent inhibitor of thymidylate synthase?

    <p>Methotrexate</p> Signup and view all the answers

    Which compound is a coenzyme for essential biochemical transformations?

    <p>Folic acid</p> Signup and view all the answers

    Which drug is known for its superior pharmacokinetic properties?

    <p>Methotrexate</p> Signup and view all the answers

    Which compound is methylated by N5, N10-methylene FH4 to give dTMP?

    <p>Deoxyuridine monophosphate (dUMP)</p> Signup and view all the answers

    Which drug inhibits DHFR and depletes the cofactor N5, N10-methylene FH4?

    <p>Methotrexate</p> Signup and view all the answers

    What is the effect of depletion of the cofactor N5,N10-methylene FH4 on cellular processes?

    <p>It has the greatest effect on dTTP synthesis.</p> Signup and view all the answers

    What is the difference between aminopterine and methotrexate?

    <p>Methotrexate has a methyl group at position R, while aminopterine does not.</p> Signup and view all the answers

    What is the role of the sulfhydryl group in thymidilate synthase enzyme during dTMP synthesis?

    <p>It is involved in the formation of the ternary complex.</p> Signup and view all the answers

    What is the mechanism of action of 5-fluorouracil (5-FU)?

    <p>5-FU inhibits the activity of thymidilate synthase enzyme.</p> Signup and view all the answers

    How does the presence of the fluorine atom in 5-fluorouracil (5-FU) affect the electrophilicity of the C6 position in FdUMP?

    <p>The fluorine atom increases the electrophilicity of the C6 position.</p> Signup and view all the answers

    What is the effect of abstraction of a C5-H by the N10 in the co-factor (Step 4 above) in the fluorinated ternary complex?

    <p>It is not possible in the fluorinated ternary complex.</p> Signup and view all the answers

    What is the effect of the absence of dTMP on cellular processes?

    <p>It blocks DNA synthesis leading to cell death.</p> Signup and view all the answers

    What makes 5-FU a particularly useful drug for the treatment of skin cancers?

    <p>It shows a high level of selectivity for cancer cells over normal skin cells.</p> Signup and view all the answers

    What is the role of the cofactor N5,N10-methylene FH4 in the normal synthesis of dTMP?

    <p>It acts as a source of carbon atoms in the reaction.</p> Signup and view all the answers

    What is the difference between deoxyuridine monophosphate (dUMP) and fluorinated deoxyuridine monophosphate (FdUMP)?

    <p>FdUMP has a fluorine atom at the C6 position, while dUMP does not.</p> Signup and view all the answers

    More Like This

    Antimetabolites in Chemotherapy
    5 questions

    Antimetabolites in Chemotherapy

    ConciliatoryRetinalite6625 avatar
    ConciliatoryRetinalite6625
    Antimetabolites in Chemotherapy
    11 questions
    Use Quizgecko on...
    Browser
    Browser