Podcast
Questions and Answers
Which of the following enzymes is NOT essential for DNA synthesis?
Which of the following enzymes is NOT essential for DNA synthesis?
- DNA polymerase
- Thymidylate synthase
- RNA polymerase (correct)
- DNA ligase
Which of the following mechanisms does NOT describe the action of antimetabolites?
Which of the following mechanisms does NOT describe the action of antimetabolites?
- Arrest of DNA chain elongation
- Promotion of nucleotide incorporation into growing DNA strand
- Inhibition of enzymes involved in DNA synthesis
- Inhibition of RNA function (correct)
Which of the following is NOT a common side effect of antimetabolite treatment?
Which of the following is NOT a common side effect of antimetabolite treatment?
- Gastrointestinal toxicity
- Neurotoxicity (correct)
- Myelosuppression
- Alopecia
Which of the following B vitamins is NOT involved in DNA synthesis?
Which of the following B vitamins is NOT involved in DNA synthesis?
Which of the following is NOT a reason for using antimetabolites in cancer treatment?
Which of the following is NOT a reason for using antimetabolites in cancer treatment?
Which of the following is NOT a risk factor for folate deficiency?
Which of the following is NOT a risk factor for folate deficiency?
Which compound acts as a one carbon source for dTMP synthesis?
Which compound acts as a one carbon source for dTMP synthesis?
Which drug is a potent inhibitor of thymidylate synthase?
Which drug is a potent inhibitor of thymidylate synthase?
Which compound is a coenzyme for essential biochemical transformations?
Which compound is a coenzyme for essential biochemical transformations?
Which drug is known for its superior pharmacokinetic properties?
Which drug is known for its superior pharmacokinetic properties?
Which compound is methylated by N5, N10-methylene FH4 to give dTMP?
Which compound is methylated by N5, N10-methylene FH4 to give dTMP?
Which drug inhibits DHFR and depletes the cofactor N5, N10-methylene FH4?
Which drug inhibits DHFR and depletes the cofactor N5, N10-methylene FH4?
What is the effect of depletion of the cofactor N5,N10-methylene FH4 on cellular processes?
What is the effect of depletion of the cofactor N5,N10-methylene FH4 on cellular processes?
What is the difference between aminopterine and methotrexate?
What is the difference between aminopterine and methotrexate?
What is the role of the sulfhydryl group in thymidilate synthase enzyme during dTMP synthesis?
What is the role of the sulfhydryl group in thymidilate synthase enzyme during dTMP synthesis?
What is the mechanism of action of 5-fluorouracil (5-FU)?
What is the mechanism of action of 5-fluorouracil (5-FU)?
How does the presence of the fluorine atom in 5-fluorouracil (5-FU) affect the electrophilicity of the C6 position in FdUMP?
How does the presence of the fluorine atom in 5-fluorouracil (5-FU) affect the electrophilicity of the C6 position in FdUMP?
What is the effect of abstraction of a C5-H by the N10 in the co-factor (Step 4 above) in the fluorinated ternary complex?
What is the effect of abstraction of a C5-H by the N10 in the co-factor (Step 4 above) in the fluorinated ternary complex?
What is the effect of the absence of dTMP on cellular processes?
What is the effect of the absence of dTMP on cellular processes?
What makes 5-FU a particularly useful drug for the treatment of skin cancers?
What makes 5-FU a particularly useful drug for the treatment of skin cancers?
What is the role of the cofactor N5,N10-methylene FH4 in the normal synthesis of dTMP?
What is the role of the cofactor N5,N10-methylene FH4 in the normal synthesis of dTMP?
What is the difference between deoxyuridine monophosphate (dUMP) and fluorinated deoxyuridine monophosphate (FdUMP)?
What is the difference between deoxyuridine monophosphate (dUMP) and fluorinated deoxyuridine monophosphate (FdUMP)?
