5 Questions
How does pemetrexed differ from methotrexate in terms of mechanism of action?
Inhibits DHFR and thymidylate synthase, as well as other enzymes involved in folate metabolism and DNA synthesis
What is the primary mechanism of action of methotrexate?
Inhibiting dihydrofolate reductase (DHFR) and interfering with DNA synthesis
Why is the maximal cytotoxic effect of antimetabolites observed in S phase of the cell cycle?
Because cells are most actively synthesizing DNA during this phase
How can the inhibition of dihydrofolate reductase (DHFR) by methotrexate be reversed?
By administration of leucovorin, which bypasses the blocked enzyme and replenishes the folate pool.
What role does folic acid play in cellular processes?
Essential for metabolic reactions involving transfer of one-carbon units and for cell replication
Test your knowledge of antimetabolites, a class of drugs that interfere with the synthesis of DNA and RNA by mimicking normal cellular compounds. Explore how these drugs work and their cell cycle specificity.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
