Antimetabolites in Cancer Treatment

Inhibits dihydrofolate reductase (DHFR) and replenishes the folate pool

Promotes the synthesis of tetrahydrofolic acid (FH4) and inhibits RNA synthesis

Inhibits DHFR and thymidylate synthase, as well as other enzymes involved in folate metabolism and DNA synthesis (correct)

Acts as an antagonist to folic acid and competes with purine nucleotide precursors

Competing with purine nucleotide precursors in RNA synthesis

Inhibiting dihydrofolate reductase (DHFR) and interfering with DNA synthesis (correct)

Acting as an antagonist to folic acid and inhibiting thymidylate synthase

Promoting the synthesis of tetrahydrofolic acid (FH4)

Because antimetabolites directly inhibit cell replication during this phase

Because cells are most actively synthesizing DNA during this phase (correct)

As S phase presents increased availability of purine and pyrimidine nucleotide precursors

Due to increased vulnerability of DNA to interference during this phase

<p>By administration of leucovorin, which bypasses the blocked enzyme and replenishes the folate pool.</p> Signup and view all the answers

<p>Essential for metabolic reactions involving transfer of one-carbon units and for cell replication</p> Signup and view all the answers