Podcast
Questions and Answers
What is the role of the TP53 gene in the cell?
What is the role of the TP53 gene in the cell?
- To convert proto-oncogenes to oncogenes
- To regulate cell cycle progression, DNA repair, and apoptosis (correct)
- To induce changes in cellular metabolism in favor of proliferation
- To promote cell proliferation and growth
What is the result of a loss of function mutation in tumor suppressor genes?
What is the result of a loss of function mutation in tumor suppressor genes?
- Failure of growth inhibition (correct)
- Induction of apoptosis
- Increased growth inhibition
- Conversion of oncogenes to proto-oncogenes
Which of the following is an example of a growth factor?
Which of the following is an example of a growth factor?
- TP53
- RB
- PTEN
- PDGF (correct)
What is the effect of oncoproteins on cellular metabolism?
What is the effect of oncoproteins on cellular metabolism?
What is the result of a gain of function mutation in growth-promoting genes?
What is the result of a gain of function mutation in growth-promoting genes?
Which of the following is a category of oncoproteins?
Which of the following is a category of oncoproteins?
What is the location of the Tp53 gene?
What is the location of the Tp53 gene?
What happens to p53 when a cell is stressed by DNA damage or hypoxia?
What happens to p53 when a cell is stressed by DNA damage or hypoxia?
What is the consequence of a loss of function mutation in P53?
What is the consequence of a loss of function mutation in P53?
What is the role of p14/ARF in p53 regulation?
What is the role of p14/ARF in p53 regulation?
Why do rapidly dividing cells need to alter their cellular metabolism?
Why do rapidly dividing cells need to alter their cellular metabolism?
What is a possible outcome of increased p53 accumulation?
What is a possible outcome of increased p53 accumulation?
What is the underlying process by which cancer cells exhibit altered cellular metabolism?
What is the underlying process by which cancer cells exhibit altered cellular metabolism?
What is the primary function of tumor suppressor genes in relation to cancer?
What is the primary function of tumor suppressor genes in relation to cancer?
Which of the following is NOT a hallmark of cancer?
Which of the following is NOT a hallmark of cancer?
What is the term for the ability of cancer cells to evade programmed cell death (apoptosis)?
What is the term for the ability of cancer cells to evade programmed cell death (apoptosis)?
What is the term for the process by which cancer cells exhibit increased glucose uptake and metabolism, even in the presence of oxygen?
What is the term for the process by which cancer cells exhibit increased glucose uptake and metabolism, even in the presence of oxygen?
What is the term for the mutations that are not necessary for cancer development, but can contribute to the malignant phenotype?
What is the term for the mutations that are not necessary for cancer development, but can contribute to the malignant phenotype?
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