Cancer Biology and Oncogenes
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Questions and Answers

What is the role of the TP53 gene in the cell?

  • To convert proto-oncogenes to oncogenes
  • To regulate cell cycle progression, DNA repair, and apoptosis (correct)
  • To induce changes in cellular metabolism in favor of proliferation
  • To promote cell proliferation and growth
  • What is the result of a loss of function mutation in tumor suppressor genes?

  • Failure of growth inhibition (correct)
  • Induction of apoptosis
  • Increased growth inhibition
  • Conversion of oncogenes to proto-oncogenes
  • Which of the following is an example of a growth factor?

  • TP53
  • RB
  • PTEN
  • PDGF (correct)
  • What is the effect of oncoproteins on cellular metabolism?

    <p>They alter cellular metabolism in favor of proliferation</p> Signup and view all the answers

    What is the result of a gain of function mutation in growth-promoting genes?

    <p>Formation of oncoproteins</p> Signup and view all the answers

    Which of the following is a category of oncoproteins?

    <p>Growth factor receptors</p> Signup and view all the answers

    What is the location of the Tp53 gene?

    <p>Chromosome 17p13.1</p> Signup and view all the answers

    What happens to p53 when a cell is stressed by DNA damage or hypoxia?

    <p>It is phosphorylated by ATM and ATR</p> Signup and view all the answers

    What is the consequence of a loss of function mutation in P53?

    <p>Cell proliferation without resistance</p> Signup and view all the answers

    What is the role of p14/ARF in p53 regulation?

    <p>It binds to MDM2 and displaces p53</p> Signup and view all the answers

    Why do rapidly dividing cells need to alter their cellular metabolism?

    <p>To harness resources to build cellular components</p> Signup and view all the answers

    What is a possible outcome of increased p53 accumulation?

    <p>Apoptosis</p> Signup and view all the answers

    What is the underlying process by which cancer cells exhibit altered cellular metabolism?

    <p>Aerobic Glycolysis</p> Signup and view all the answers

    What is the primary function of tumor suppressor genes in relation to cancer?

    <p>To inhibit cell growth and division</p> Signup and view all the answers

    Which of the following is NOT a hallmark of cancer?

    <p>Differentiation into a benign tumor</p> Signup and view all the answers

    What is the term for the ability of cancer cells to evade programmed cell death (apoptosis)?

    <p>Evasion of apoptosis</p> Signup and view all the answers

    What is the term for the process by which cancer cells exhibit increased glucose uptake and metabolism, even in the presence of oxygen?

    <p>Warburg effect</p> Signup and view all the answers

    What is the term for the mutations that are not necessary for cancer development, but can contribute to the malignant phenotype?

    <p>Passenger mutations</p> Signup and view all the answers

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