Podcast
Questions and Answers
What is the primary factor influencing absorption through endothelial pores in intramuscular, subcutaneous, and intradermal routes of exposure?
What is the primary factor influencing absorption through endothelial pores in intramuscular, subcutaneous, and intradermal routes of exposure?
- Lipid solubility
- Site of skin thickness
- Surface area
- Blood flow (correct)
What is the bioavailability of a drug administered intravenously?
What is the bioavailability of a drug administered intravenously?
- 50%
- Ranges from 0 to 100%
- 100% (correct)
- 35%
Why is it essential to understand bioavailability and extent of absorption for xenobiotics?
Why is it essential to understand bioavailability and extent of absorption for xenobiotics?
- To determine the optimal dose for therapeutic effects
- To assess the risk of toxic effects (correct)
- To identify the most suitable route of administration
- To evaluate the efficacy of detoxification pathways
What is the primary mechanism of destruction of lidocaine in the body?
What is the primary mechanism of destruction of lidocaine in the body?
What is the term for the phenomenon where a drug is destroyed or metabolized before it reaches the systemic circulation?
What is the term for the phenomenon where a drug is destroyed or metabolized before it reaches the systemic circulation?
Which route of exposure has a large surface area?
Which route of exposure has a large surface area?
What is the primary factor influencing the absorption of xenobiotics through the skin?
What is the primary factor influencing the absorption of xenobiotics through the skin?
What is the primary factor determining the selective transport of ions through ion channels?
What is the primary factor determining the selective transport of ions through ion channels?
Which of the following is an example of a cation transport channel?
Which of the following is an example of a cation transport channel?
What is the primary mechanism of lead absorption from the intestine to the blood?
What is the primary mechanism of lead absorption from the intestine to the blood?
What is the primary effect of lead poisoning on children?
What is the primary effect of lead poisoning on children?
What is the primary prevention strategy for chronic lead poisoning?
What is the primary prevention strategy for chronic lead poisoning?
What is the radioactive isotope of iodine that can cause thyroid cancer?
What is the radioactive isotope of iodine that can cause thyroid cancer?
What was the event that led to the series of equipment failures and releases of radioactive materials at the Fukushima I Nuclear Power Plant?
What was the event that led to the series of equipment failures and releases of radioactive materials at the Fukushima I Nuclear Power Plant?
What is the primary mechanism by which lead enters the blood from the gut?
What is the primary mechanism by which lead enters the blood from the gut?
What is the primary target tissue for blood lead toxicity?
What is the primary target tissue for blood lead toxicity?
Which of the following xenobiotics is NOT sequestered in adipose tissue?
Which of the following xenobiotics is NOT sequestered in adipose tissue?
What is the purpose of depot sequestration and mobilization in the context of xenobiotic toxicity?
What is the purpose of depot sequestration and mobilization in the context of xenobiotic toxicity?
Which of the following xenobiotics is characterized by a short-acting effect due to re-distribution from the brain to fat?
Which of the following xenobiotics is characterized by a short-acting effect due to re-distribution from the brain to fat?
What is the primary consequence of depot mobilization of sequestered xenobiotics during pregnancy and breast feeding?
What is the primary consequence of depot mobilization of sequestered xenobiotics during pregnancy and breast feeding?
What is the primary mechanism of elimination for xenobiotics such as ammonia and volatile organic compounds?
What is the primary mechanism of elimination for xenobiotics such as ammonia and volatile organic compounds?
What is the primary reason for the low bioavailability of certain xenobiotics in extracellular fluid?
What is the primary reason for the low bioavailability of certain xenobiotics in extracellular fluid?
Which of the following statements about brain capillaries is true?
Which of the following statements about brain capillaries is true?
What is the effect of tolbutamide binding to plasma albumin?
What is the effect of tolbutamide binding to plasma albumin?
What is the purpose of the blood-brain barrier (BBB)?
What is the purpose of the blood-brain barrier (BBB)?
What is the effect of competition-displacement between xenobiotics on their bioavailability?
What is the effect of competition-displacement between xenobiotics on their bioavailability?
What is the purpose of sequestration in animals?
What is the purpose of sequestration in animals?
What is the difference between normal blood capillaries and brain capillaries?
What is the difference between normal blood capillaries and brain capillaries?
What is the primary mechanism of excretion for water-soluble toxicants with a molecular weight of less than 70,000?
What is the primary mechanism of excretion for water-soluble toxicants with a molecular weight of less than 70,000?
Which of the following elimination routes involves both filtration and reabsorption processes?
Which of the following elimination routes involves both filtration and reabsorption processes?
What is the primary function of the liver in the elimination of toxicants?
What is the primary function of the liver in the elimination of toxicants?
What is the significance of mother's milk as an elimination route?
What is the significance of mother's milk as an elimination route?
What is the mechanism of excretion of conjugates with high molecular weight?
What is the mechanism of excretion of conjugates with high molecular weight?
What is the fate of lipid-soluble and non-ionized toxicants in the body?
What is the fate of lipid-soluble and non-ionized toxicants in the body?
What is the primary route of elimination for gases and volatile liquids?
What is the primary route of elimination for gases and volatile liquids?
What is the role of the GIT in the elimination of toxicants?
What is the role of the GIT in the elimination of toxicants?
What is the significance of sweat and saliva as elimination routes?
What is the significance of sweat and saliva as elimination routes?