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A transporter protein designed for D-glucose is observed to also bind to D-galactose. What is the most likely effect of this?
A transporter protein designed for D-glucose is observed to also bind to D-galactose. What is the most likely effect of this?
What is the term for the likelihood of an ion channel being open, which directly affects the rate of diffusion through it?
What is the term for the likelihood of an ion channel being open, which directly affects the rate of diffusion through it?
What type of ion channel responds to changes in the concentration of hormones or neurotransmitters?
What type of ion channel responds to changes in the concentration of hormones or neurotransmitters?
If the membrane potential of a cell changes, which type of ion channel would be most likely to respond?
If the membrane potential of a cell changes, which type of ion channel would be most likely to respond?
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What is the primary mechanism responsible for creating the chemical gradients of ions across the cell membrane?
What is the primary mechanism responsible for creating the chemical gradients of ions across the cell membrane?
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According to the provided content, what does the variable 'D' represent in the permeability coefficient (P) equation?
According to the provided content, what does the variable 'D' represent in the permeability coefficient (P) equation?
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If the membrane thickness (∆X) increases, what would be the effect on the flux (J), assuming all other factors remain constant?
If the membrane thickness (∆X) increases, what would be the effect on the flux (J), assuming all other factors remain constant?
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In carrier-mediated transport, what does 'Tm' represent?
In carrier-mediated transport, what does 'Tm' represent?
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How does an increase in temperature affect the rate of diffusion?
How does an increase in temperature affect the rate of diffusion?
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What property of carrier proteins allows them to distinguish between D-glucose and L-glucose?
What property of carrier proteins allows them to distinguish between D-glucose and L-glucose?
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What happens to the rate of transport in carrier-mediated transport and with many binding sites available when solute concentration is low?
What happens to the rate of transport in carrier-mediated transport and with many binding sites available when solute concentration is low?
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A substance 'X' is transported via a carrier protein but does not use the same binding site as glucose. What effect would an increased amount of 'X' likely have on glucose transport?
A substance 'X' is transported via a carrier protein but does not use the same binding site as glucose. What effect would an increased amount of 'X' likely have on glucose transport?
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According to the permeability equation, which variable represents the difference in concentration between two compartments?
According to the permeability equation, which variable represents the difference in concentration between two compartments?
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Which of the following best describes the behavior of urea with respect to cell membranes?
Which of the following best describes the behavior of urea with respect to cell membranes?
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What primarily determines the osmotic pressure and movement of water across a cell membrane?
What primarily determines the osmotic pressure and movement of water across a cell membrane?
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A cell is placed in a solution with a higher concentration of impermeant solutes than its intracellular fluid. How would this solution be described?
A cell is placed in a solution with a higher concentration of impermeant solutes than its intracellular fluid. How would this solution be described?
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Which of these transport mechanisms directly uses ATP to move substances across the cell membrane?
Which of these transport mechanisms directly uses ATP to move substances across the cell membrane?
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If the membrane potential is at -70mV, and the equilibrium potential for potassium ions is -94mV, what is the driving force for potassium diffusion?
If the membrane potential is at -70mV, and the equilibrium potential for potassium ions is -94mV, what is the driving force for potassium diffusion?
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Which of the following is a key feature of facilitated diffusion?
Which of the following is a key feature of facilitated diffusion?
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What primarily establishes the negative intracellular charge within a cell?
What primarily establishes the negative intracellular charge within a cell?
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What is the main driving force behind the movement of substances in simple diffusion?
What is the main driving force behind the movement of substances in simple diffusion?
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How does the membrane potential (Em) relate to the equilibrium potential of the most permeable ion?
How does the membrane potential (Em) relate to the equilibrium potential of the most permeable ion?
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In secondary active transport, what is the source of energy that moves a substance against its concentration gradient?
In secondary active transport, what is the source of energy that moves a substance against its concentration gradient?
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What is the state when the chemical and electrical forces acting on an ion are in balance.
What is the state when the chemical and electrical forces acting on an ion are in balance.
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Which of the transport mechanisms does a white blood cell primarily use to engulf bacteria?
Which of the transport mechanisms does a white blood cell primarily use to engulf bacteria?
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What effect does opening ion channels normally have on intracellular and extracellular ion concentrations?
What effect does opening ion channels normally have on intracellular and extracellular ion concentrations?
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Which receptor type directly mediates changes in membrane potential by altering ion permeability?
Which receptor type directly mediates changes in membrane potential by altering ion permeability?
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The activation of a Gq protein-coupled receptor would most directly lead to an increase in which of the following second messengers?
The activation of a Gq protein-coupled receptor would most directly lead to an increase in which of the following second messengers?
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Which of the following receptor types primarily influences gene expression?
Which of the following receptor types primarily influences gene expression?
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Which of the following signaling molecules directly activates a receptor guanylate cyclase?
Which of the following signaling molecules directly activates a receptor guanylate cyclase?
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A receptor tyrosine phosphatase, when bound to its ligand, results in which of the following?
A receptor tyrosine phosphatase, when bound to its ligand, results in which of the following?
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What is a key characteristic of a normal action potential for a given cell type?
What is a key characteristic of a normal action potential for a given cell type?
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How is the action potential propagated along the axon?
How is the action potential propagated along the axon?
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An action potential is described as an 'all-or-none' response as it means:
An action potential is described as an 'all-or-none' response as it means:
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During the absolute refractory period, why is it impossible to elicit a new action potential even with a very strong stimulus?
During the absolute refractory period, why is it impossible to elicit a new action potential even with a very strong stimulus?
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Which of these describes the relative refractory period?
Which of these describes the relative refractory period?
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How do local currents contribute to action potential propagation?
How do local currents contribute to action potential propagation?
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Where is the action potential typically initiated in a neuron?
Where is the action potential typically initiated in a neuron?
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Which of the following factors influence the conduction velocity of action potentials in nerves?
Which of the following factors influence the conduction velocity of action potentials in nerves?
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Flashcards
Equilibrium Potential
Equilibrium Potential
The membrane potential at which the chemical gradient driving an ion across the membrane is exactly balanced by the electrical gradient.
Driving Force
Driving Force
The difference between the resting membrane potential (RMP) and the equilibrium potential for a specific ion.
Selective Membrane Permeability
Selective Membrane Permeability
The cell membrane allows some ions to pass through more easily than others.
Membrane Potential and Permeability
Membrane Potential and Permeability
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Electrical Gradient Generation
Electrical Gradient Generation
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Channel Conductance
Channel Conductance
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Diffusion Flux (J)
Diffusion Flux (J)
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Permeability Coefficient (P)
Permeability Coefficient (P)
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Voltage-gated Channels
Voltage-gated Channels
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Ligand-gated Channels
Ligand-gated Channels
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Partition Coefficient (K)
Partition Coefficient (K)
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Second-messenger-gated Channels
Second-messenger-gated Channels
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Diffusion Coefficient (D)
Diffusion Coefficient (D)
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Mechanically-gated Channels
Mechanically-gated Channels
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Membrane Thickness (∆X)
Membrane Thickness (∆X)
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Concentration Gradient (∆C)
Concentration Gradient (∆C)
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Transport Maximum (Tm)
Transport Maximum (Tm)
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Stereospecificity
Stereospecificity
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What is an ineffective osmole?
What is an ineffective osmole?
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What determines osmotic pressure?
What determines osmotic pressure?
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What is an isotonic solution?
What is an isotonic solution?
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What is a hypotonic solution?
What is a hypotonic solution?
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What is a hypertonic solution?
What is a hypertonic solution?
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What is simple diffusion?
What is simple diffusion?
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What is facilitated diffusion?
What is facilitated diffusion?
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What is active transport?
What is active transport?
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Ligand-gated ion channels
Ligand-gated ion channels
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G protein-coupled receptors (GPCRs)
G protein-coupled receptors (GPCRs)
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First messenger
First messenger
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Second messenger
Second messenger
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Enzyme-linked receptors
Enzyme-linked receptors
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What is meant by the statement that action potentials of a given neuron are identical?
What is meant by the statement that action potentials of a given neuron are identical?
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How is an action potential propagated down an axon?
How is an action potential propagated down an axon?
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What is meant by the 'all-or-none' principle of action potentials?
What is meant by the 'all-or-none' principle of action potentials?
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What is the absolute refractory period?
What is the absolute refractory period?
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What is the relative refractory period?
What is the relative refractory period?
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What is conduction velocity?
What is conduction velocity?
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What is membrane resistance?
What is membrane resistance?
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What is internal resistance?
What is internal resistance?
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Study Notes
Homeostasis
- Homeostasis is a steady state, not equilibrium
- Homeostasis requires energy
- Equilibrium does not require energy and is a state where there is no change in a vital parameter
- A steady state is when a vital parameter is well-regulated
- The body maintains a constant value for a parameter adjusting actions up or down as needed
- Negative feedback returns a vital parameter to its stable point
- Negative feedback maintains homeostasis
- When a parameter deviates from its stable point, negative feedback is activated
- Negative feedback leads to a series of changes
- A stimulus is recognized by a receptor
- The control center compares input to the reference value (set point)
- Effectors make adjustments
- Positive feedback loops amplify a stimulus and accelerate it
- A positive feedback loop can lead to instability and death
Electrolyte Content of Body Fluids
- Electrolytes are measured in mEq/L (milliequivalents per liter)
- Cations and anions are listed in a table displaying the concentration of various electrolytes in plasma, interstitial fluid, and intracellular fluid
- Examples of cations are sodium, potassium, calcium, and magnesium
- Examples of anions are chloride, bicarbonate, sulfate, phosphate, and protein
Osmotic Pressure and Reflection Coefficient
- Osmolarity is the concentration of solute particles within a solution and used to determine osmotic pressure
- Solutes with a reflection coefficient of 0 (σ = 0) move freely across a membrane
- Determining which solute is permeable is crucial when measuring osmotic pressure
- Isotonic solutions are always iso-osmotic, but iso-osmotic solutions may not be isotonic; if the reflection coefficient is not zero
- The concentration of impermeable solute determines osmotic pressure and water movement
Tonicity of Solutions
- Isotonic solutions do not change cell volume
- Hypotonic solutions cause cells to swell
- Hypertonic solutions cause cells to shrink
Transport Function of the Plasma Membrane
- Simple diffusion follows the electrochemical gradient
- Facilitated diffusion follows the electrochemical gradient with a protein carrier
- Primary active transport goes against the electrochemical gradient using ATP directly
- Secondary active transport uses the electrochemical gradient produced by a primary active transport system
Fick's Law of Diffusion
- Fick's Law relates the diffusive flux to the concentration gradient across a membrane
- Rate of diffusion is proportional to the permeability coefficient times the concentration difference divided by the thickness of the membrane
- Temperature positively correlates with the rate of diffusion
Saturation in Carrier-Mediated Transport
- Membrane proteins transport solute molecules
- Carrier-mediated transport has a maximum transport rate
- At low concentrations, transport increases proportionally to the concentration of solute until all the transport proteins are occupied.
- Transport maximum (Tm) is when all transport sites are occupied.
- The rate of transport becomes constant no matter how high the solute concentration increases
Stereospecificity in Carrier-Mediated Transport
- Binding sites are highly specific
- Stereospecificity means the transported molecule must be the correct isomer
- The transporter for glucose is highly specific to naturally-occurring D-glucose and doesn't transport its mirror image L-glucose
Competition in Carrier-Mediated Transport
- Similar solutes can compete for binding sites
- A closely related solute might occupy transport sites reducing the availability of sites to transport the primary solute
Ion Channel Characteristics
- Conductance (g) is the probability the channel is open, increasing the rate of diffusion
- Channels are controlled by different sensors such as: Voltage, Ligand, Second-messenger, Mechanically-gated
- Different types of sensors elicit different responses
- Ion movement through the channels depends on the relative concentration of ions and the voltage gradient across the membrane
Mechanisms Responsible for the Resting Membrane Potential
- Concentration gradients (chemical gradient) are across the membrane due to active transport (pumps)
- Selective membrane permeability selectively allows potassium (K+) to move across the membrane.
- Electrical gradients are generated by K+ leak which creates a negative intracellular charge
Equilibrium Potential
- The electrical potential difference that exactly balances an ion's concentration gradient across a membrane
- At equilibrium potential, there is no net flow
Driving Force for Diffusion: Equilibrium Potential vs. RMP
- The driving force for an ion is the difference between the membrane potential (RMP) and the equilibrium potential for the ion
- Forces can be positive or negative
Characteristics of Action Potentials
- Stereotypical in size and shape for a given cell type
- Propagate along a membrane, non-decremental
- All-or-none response
Action Potential Sequence
- Depolarization: Na+ channels open and Na+ enters
- Repolarization: Na+ channels close and K+ channels open, K+ leaves
- Hyperpolarization: K+ channels are slow to close and K+ continues to leave.
Refractory Periods
- Absolute refractory period: No action potential can be generated no matter the stimulus
- Relative refractory period: An action potential can be generated but requires a stronger stimulus than usual
Propagation of Action Potentials
- Action potentials propagate along a membrane
- Spread of local currents to adjacent, inactive regions
- Initiation of Aps in the initial segment of axon
Factors Affecting Conduction Velocity in Nerves
- Factors affecting conduction velocities include myelination, axon diameter, temperature.
Receptors, Signaling Pathways, and Messengers
- Different types of receptors and how they signal inside a cell.
- Ligand-gated ion channels, G protein-coupled receptors, enzyme-linked receptors, and nuclear receptors are listed.
- The signaling pathway for each receptor and the 2nd messengers are listed
Good Study Habits
- Effective study habits include a consistent schedule, active note-taking, study breaks, an organized workspace, prioritized tasks, a distraction-free environment, peer study groups, and periodic review sessions.
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Description
Test your understanding of the mechanisms involved in cell membrane transport, including the functioning of transporter proteins and ion channels. This quiz covers key concepts such as permeability coefficients, diffusion rates, and gradients of ions. Enhance your knowledge about how various factors affect these processes.