9 Questions
What is the concern regarding Azathioprine as mentioned in the text?
Cytotoxic properties
What is Azathioprine metabolized into before turning into active metabolites?
6-mercaptopurine (6-MP)
What is the potential risk associated with gene mutations that diminish TPMT activity?
Increase in toxic metabolites and side effects like bone marrow suppression
What aspect should be considered when deciding to use Azathioprine in lactating mothers?
Potential benefits outweighing risks
What did the BNF Mar21 mention about Azathioprine in breast milk?
Present in low concentration with no evidence of harm in small studies
Which enzyme's genotype in the mother can influence the activity of Azathioprine?
Thiopurine methyltransferase (TPMT)
What was studied in relation to 6-mercaptopurine (6-MP) levels as per the text?
Concentrations in maternal milk
Why are gene mutations affecting TPMT activity a concern?
They lead to an increase in toxic metabolites and side effects like bone marrow suppression
What was Alimentary Pharmacology & Therapeutics focused on regarding Azathioprine?
Treatment during lactation
Explore the application of WHO guidelines on breastfeeding and medication use in practice, focusing on benefits for infants and maternal health. Delve into the recommendations by a senior pharmacist and clinical lecturer.
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