Breastfeeding and Medication Use - Theory into Practice
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Questions and Answers

What is the concern regarding Azathioprine as mentioned in the text?

  • Potential for allergic reactions
  • Hormonal imbalance
  • Risk of liver damage
  • Cytotoxic properties (correct)

What is Azathioprine metabolized into before turning into active metabolites?

  • Thiopurine methyltransferase (TPMT)
  • Breast milk levels
  • Common infections
  • 6-mercaptopurine (6-MP) (correct)

What is the potential risk associated with gene mutations that diminish TPMT activity?

  • Improvement in maternal milk quality
  • Increase in toxic metabolites and side effects like bone marrow suppression (correct)
  • Enhancement of growth and development in infants
  • Reduction in common infections

What aspect should be considered when deciding to use Azathioprine in lactating mothers?

<p>Potential benefits outweighing risks (C)</p> Signup and view all the answers

What did the BNF Mar21 mention about Azathioprine in breast milk?

<p>Present in low concentration with no evidence of harm in small studies (A)</p> Signup and view all the answers

Which enzyme's genotype in the mother can influence the activity of Azathioprine?

<p>Thiopurine methyltransferase (TPMT) (D)</p> Signup and view all the answers

What was studied in relation to 6-mercaptopurine (6-MP) levels as per the text?

<p>Concentrations in maternal milk (D)</p> Signup and view all the answers

Why are gene mutations affecting TPMT activity a concern?

<p>They lead to an increase in toxic metabolites and side effects like bone marrow suppression (D)</p> Signup and view all the answers

What was Alimentary Pharmacology & Therapeutics focused on regarding Azathioprine?

<p>Treatment during lactation (B)</p> Signup and view all the answers

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