Breast Pathology MBChB III by Dr. Susan Aketch
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Questions and Answers

What is the most common presentation of benign non-proliferative breast changes?

  • Breast lumps (correct)
  • Cystic dilatation of ducts
  • Nodules or masses
  • Tender breasts
  • Which type of breast changes are characterized by variable cystic dilatation of ducts and stromal fibrosis?

  • Miscellaneous lesions
  • Inflammatory lesions
  • Benign proliferative breast changes (correct)
  • Tumours
  • What are unopened cysts in benign non-proliferative breast changes often filled with?

  • Pus
  • Blood
  • Air
  • Turbid fluid (correct)
  • Which type of lesion typically arises during lactation, is painful, and may rupture causing a local inflammatory reaction?

    <p>Galactocoele</p> Signup and view all the answers

    Which type of breast changes are often bilateral and multi-focal, with ill-defined diffuse nodularity?

    <p>Benign proliferative breast changes</p> Signup and view all the answers

    What may calcify within cysts in benign non-proliferative breast changes, appearing as micro-calcifications on mammograms?

    <p>Turbid fluid</p> Signup and view all the answers

    What is the commonest benign tumor of the female breast?

    <p>Fibroadenoma</p> Signup and view all the answers

    At what age is fibroadenoma most commonly seen?

    <p>3rd decade</p> Signup and view all the answers

    Which tumor is thought to arise from the intra-lobular stroma?

    <p>Phyllodes tumor</p> Signup and view all the answers

    What is a characteristic feature of fibroadenoma when described grossly?

    <p>Leaf-like clefts</p> Signup and view all the answers

    Which tumor may show an ominous change with increased stromal cellularity and high mitotic activity?

    <p>Phyllodes tumor</p> Signup and view all the answers

    What is the cytogenetic element that is considered neoplastic in fibroadenoma?

    <p>Stroma</p> Signup and view all the answers

    What is Mammary Duct Ectasia commonly associated with?

    <p>Non-bacterial inflammation</p> Signup and view all the answers

    Which group of individuals is most commonly affected by Duct Ectasia?

    <p>Women in their 40s &amp; 50s who have borne children</p> Signup and view all the answers

    What is the most distinctive feature of Duct Ectasia when observed under a microscope?

    <p>Prominence of lymphocytic &amp; plasma cell infiltration</p> Signup and view all the answers

    Which condition may mimic cancer due to similarities in skin retraction and induration?

    <p>Mammary Duct Ectasia</p> Signup and view all the answers

    What are the early stages of Traumatic Fat Necrosis characterized by?

    <p><strong>Inflammatory changes</strong></p> Signup and view all the answers

    What is the main clinical significance of Traumatic Fat Necrosis?

    <p><strong>Formation of a mass</strong></p> Signup and view all the answers

    What is the most common cancer among women globally?

    <p>Breast cancer</p> Signup and view all the answers

    Which risk factor is significantly higher in North America and northern Europe compared to Asia and Africa?

    <p>Geographical variation</p> Signup and view all the answers

    What is the typical presentation of an intra-ductal papilloma?

    <p>Serous or bloody nipple discharge</p> Signup and view all the answers

    Which genetic mutation is associated with Li-Fraumeni Syndrome and an increased risk of early-onset breast cancer?

    <p>P53</p> Signup and view all the answers

    What is the approximate percentage of breast cancer cases related to specific inherited mutations?

    <p>50%</p> Signup and view all the answers

    In Kenya, which type of cancer has a higher incidence than breast cancer?

    <p>Cancer of the cervix</p> Signup and view all the answers

    Which type of breast change is characterized by cells resembling carcinoma in situ but not filling or distending more than 50% of the terminal duct unit?

    <p>Atypical Lobular Hyperplasia</p> Signup and view all the answers

    What is the significance of Sclerosing Adenosis compared to other benign breast changes?

    <p>Associated with minimal risk of cancer</p> Signup and view all the answers

    What characterizes the multi-layered, disorderly cells with nuclear hyperchromasia seen in Epithelial Hyperplasia with atypia?

    <p>Variation in nuclear and cell size, shape</p> Signup and view all the answers

    Which breast change shows compressed dense fibrous connective tissue in the stroma?

    <p>Sclerosing Adenosis</p> Signup and view all the answers

    Which benign proliferative breast change has an almost infinite spectrum of proliferative alterations observed under microscopy?

    <p>FCC- Proliferative Changes</p> Signup and view all the answers

    What differentiates mild epithelial hyperplasia from florid, atypical epithelial hyperplasia in terms of cancer risk?

    <p>Number of layers of epithelial cells</p> Signup and view all the answers

    'FCC' refers to which benign breast changes that are often dominated by co-existing fibrosis and cystic alterations?

    <p>'FCC- Proliferative Changes'</p> Signup and view all the answers

    What is a common histological feature seen in FCC that may not often produce a discrete breast mass?

    <p>Microcalcifications on mammograms</p> Signup and view all the answers

    'Apocrine changes' are frequently seen in which type of benign breast change?

    <p>'FCC- Proliferative Changes'</p> Signup and view all the answers

    'Marked intra-lobular fibrosis with proliferation of small ductules & acini' is a characteristic feature of which benign breast change?

    <p>'Sclerosing Adenosis'</p> Signup and view all the answers

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