Breast Pathology MBChB III by Dr. Susan Aketch
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Questions and Answers

What is the most common presentation of benign non-proliferative breast changes?

  • Breast lumps (correct)
  • Cystic dilatation of ducts
  • Nodules or masses
  • Tender breasts

Which type of breast changes are characterized by variable cystic dilatation of ducts and stromal fibrosis?

  • Miscellaneous lesions
  • Inflammatory lesions
  • Benign proliferative breast changes (correct)
  • Tumours

What are unopened cysts in benign non-proliferative breast changes often filled with?

  • Pus
  • Blood
  • Air
  • Turbid fluid (correct)

Which type of lesion typically arises during lactation, is painful, and may rupture causing a local inflammatory reaction?

<p>Galactocoele (C)</p> Signup and view all the answers

Which type of breast changes are often bilateral and multi-focal, with ill-defined diffuse nodularity?

<p>Benign proliferative breast changes (C)</p> Signup and view all the answers

What may calcify within cysts in benign non-proliferative breast changes, appearing as micro-calcifications on mammograms?

<p>Turbid fluid (D)</p> Signup and view all the answers

What is the commonest benign tumor of the female breast?

<p>Fibroadenoma (D)</p> Signup and view all the answers

At what age is fibroadenoma most commonly seen?

<p>3rd decade (C)</p> Signup and view all the answers

Which tumor is thought to arise from the intra-lobular stroma?

<p>Phyllodes tumor (C)</p> Signup and view all the answers

What is a characteristic feature of fibroadenoma when described grossly?

<p>Leaf-like clefts (D)</p> Signup and view all the answers

Which tumor may show an ominous change with increased stromal cellularity and high mitotic activity?

<p>Phyllodes tumor (C)</p> Signup and view all the answers

What is the cytogenetic element that is considered neoplastic in fibroadenoma?

<p>Stroma (D)</p> Signup and view all the answers

What is Mammary Duct Ectasia commonly associated with?

<p>Non-bacterial inflammation (C)</p> Signup and view all the answers

Which group of individuals is most commonly affected by Duct Ectasia?

<p>Women in their 40s &amp; 50s who have borne children (B)</p> Signup and view all the answers

What is the most distinctive feature of Duct Ectasia when observed under a microscope?

<p>Prominence of lymphocytic &amp; plasma cell infiltration (A)</p> Signup and view all the answers

Which condition may mimic cancer due to similarities in skin retraction and induration?

<p>Mammary Duct Ectasia (B)</p> Signup and view all the answers

What are the early stages of Traumatic Fat Necrosis characterized by?

<p><strong>Inflammatory changes</strong> (D)</p> Signup and view all the answers

What is the main clinical significance of Traumatic Fat Necrosis?

<p><strong>Formation of a mass</strong> (B)</p> Signup and view all the answers

What is the most common cancer among women globally?

<p>Breast cancer (B)</p> Signup and view all the answers

Which risk factor is significantly higher in North America and northern Europe compared to Asia and Africa?

<p>Geographical variation (C)</p> Signup and view all the answers

What is the typical presentation of an intra-ductal papilloma?

<p>Serous or bloody nipple discharge (C)</p> Signup and view all the answers

Which genetic mutation is associated with Li-Fraumeni Syndrome and an increased risk of early-onset breast cancer?

<p>P53 (C)</p> Signup and view all the answers

What is the approximate percentage of breast cancer cases related to specific inherited mutations?

<p>50% (D)</p> Signup and view all the answers

In Kenya, which type of cancer has a higher incidence than breast cancer?

<p>Cancer of the cervix (B)</p> Signup and view all the answers

Which type of breast change is characterized by cells resembling carcinoma in situ but not filling or distending more than 50% of the terminal duct unit?

<p>Atypical Lobular Hyperplasia (A)</p> Signup and view all the answers

What is the significance of Sclerosing Adenosis compared to other benign breast changes?

<p>Associated with minimal risk of cancer (A)</p> Signup and view all the answers

What characterizes the multi-layered, disorderly cells with nuclear hyperchromasia seen in Epithelial Hyperplasia with atypia?

<p>Variation in nuclear and cell size, shape (B)</p> Signup and view all the answers

Which breast change shows compressed dense fibrous connective tissue in the stroma?

<p>Sclerosing Adenosis (D)</p> Signup and view all the answers

Which benign proliferative breast change has an almost infinite spectrum of proliferative alterations observed under microscopy?

<p>FCC- Proliferative Changes (B)</p> Signup and view all the answers

What differentiates mild epithelial hyperplasia from florid, atypical epithelial hyperplasia in terms of cancer risk?

<p>Number of layers of epithelial cells (D)</p> Signup and view all the answers

'FCC' refers to which benign breast changes that are often dominated by co-existing fibrosis and cystic alterations?

<p>'FCC- Proliferative Changes' (B)</p> Signup and view all the answers

What is a common histological feature seen in FCC that may not often produce a discrete breast mass?

<p>Microcalcifications on mammograms (C)</p> Signup and view all the answers

'Apocrine changes' are frequently seen in which type of benign breast change?

<p>'FCC- Proliferative Changes' (A)</p> Signup and view all the answers

'Marked intra-lobular fibrosis with proliferation of small ductules & acini' is a characteristic feature of which benign breast change?

<p>'Sclerosing Adenosis' (B)</p> Signup and view all the answers

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