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Questions and Answers
What is the underlying cause of the changes in the breast tissue?
Which type of change is the most common in the breast tissue?
What is characteristic of nonproliferative change in the breast tissue?
What is the significance of sclerosing adenosis in the breast tissue?
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Which type of proliferative change carries a significantly greater risk of carcinoma?
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What is a characteristic of proliferative change in the breast tissue?
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At what age does fibroadenoma usually appear?
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What is the typical size range of a fibroadenoma?
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What is the characteristic of the ductal spaces in pericanalicular fibroadenoma?
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What surrounds a fibroadenoma?
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What is the characteristic of the cells lining the ductal spaces in fibroadenoma?
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What is the characteristic of giant fibroadenoma?
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Study Notes
Breast Tissue Alterations
- Exaggeration and distortion of normal cyclic breast changes in the menstrual cycle lead to a range of alterations.
Nonproliferative Change
- Characterized by an increase in fibrous stroma associated with duct dilation and formation of cysts of various sizes.
- Most common type of alteration.
Proliferative Change
- Includes proliferative lesions within ductules, terminal ducts, and sometimes lobules of the breast.
- Epithelial hyperplasias can be mild and orderly, carrying little risk of carcinoma, or florid and atypical, carrying a significantly greater risk.
Sclerosing Adenosis
- Less common than cysts and hyperplasia, but significant due to its deceptively similar clinical and morphologic features to those of carcinoma.
- Characterized by marked intralobular fibrosis and proliferation of small ductules and acini.
Fibroadenoma
- Most common benign tumor of the female breast.
- Thought to develop due to absolute or relative increase in estrogen activity.
- Usually appears in young women, with peak incidence in the third decade of life.
- Morphology: well-defined, solitary, freely movable nodule, 1-10 cm in diameter, rarely multiple tumors or exceeding 10 cm in diameter (giant fibroadenoma).
- Histology: loose fibroblastic stroma containing ductlike, epithelium-lined spaces of various forms and sizes, with single or multiple layers of regular cells and a well-defined, intact basement membrane.
- Surrounded by a fibrous capsule.
Fibroadenoma Variations
- Pericanalicular fibroadenoma: ductal spaces are open, round to oval, and fairly regular.
- Intracanalicular fibroadenoma: ductal spaces are compressed by extensive proliferation of the stroma, appearing as slits or irregular, star-shaped structures on cross-section.
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Description
Test your knowledge of breast pathology with this quiz, covering nonproliferative and proliferative changes, including cysts, fibrosis, and epithelial hyperplasia. Learn about the morphology of breast tissue and common alterations. Evaluate your understanding of breast disease and its characteristics.
