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Questions and Answers
Which phase of the cell cycle involves the synthesis of cellular components needed for DNA synthesis?
Which phase of the cell cycle involves the synthesis of cellular components needed for DNA synthesis?
Which type of drugs act on cells regardless of the phase of the cell cycle they are in?
Which type of drugs act on cells regardless of the phase of the cell cycle they are in?
Which phase of the cell cycle is the quiescent or dormant phase of cells?
Which phase of the cell cycle is the quiescent or dormant phase of cells?
Which class of drugs form DNA cross-links and inhibit DNA synthesis?
Which class of drugs form DNA cross-links and inhibit DNA synthesis?
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What is the purpose of neoadjuvant chemotherapy?
What is the purpose of neoadjuvant chemotherapy?
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According to the log-kill hypothesis, what do cancer drugs do?
According to the log-kill hypothesis, what do cancer drugs do?
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What is the purpose of adjuvant chemotherapy?
What is the purpose of adjuvant chemotherapy?
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Which drugs are used in cancer treatment to inhibit DNA synthesis?
Which drugs are used in cancer treatment to inhibit DNA synthesis?
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What is the mechanism of action of cisplatin and similar drugs?
What is the mechanism of action of cisplatin and similar drugs?
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When are rescue drugs administered in cancer treatment?
When are rescue drugs administered in cancer treatment?
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What is the purpose of cell cycle specific drugs?
What is the purpose of cell cycle specific drugs?
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What is the purpose of drug combinations in cancer treatment?
What is the purpose of drug combinations in cancer treatment?
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What is the purpose of alkylating agents in cancer treatment?
What is the purpose of alkylating agents in cancer treatment?
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Which drug is ideal for hormonal therapy in hormone-sensitive breast cancer?
Which drug is ideal for hormonal therapy in hormone-sensitive breast cancer?
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What is effective for HER-2/neu receptor positive breast cancer?
What is effective for HER-2/neu receptor positive breast cancer?
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What is used for acute lymphoblastic leukemia to deplete serum asparagine?
What is used for acute lymphoblastic leukemia to deplete serum asparagine?
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What inhibits VEGF signaling and is used for various cancers?
What inhibits VEGF signaling and is used for various cancers?
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Which drug allows DNA transcription and differentiation of immature leukemic cells?
Which drug allows DNA transcription and differentiation of immature leukemic cells?
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Which monoclonal antibody is used in Non-Hodgkin's lymphoma?
Which monoclonal antibody is used in Non-Hodgkin's lymphoma?
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Which drug suppresses inflammation and immune response and is used in leukemia and lymphomas?
Which drug suppresses inflammation and immune response and is used in leukemia and lymphomas?
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What type of breast cancer is ideal for hormonal therapy with drugs like Letrozole?
What type of breast cancer is ideal for hormonal therapy with drugs like Letrozole?
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What are being researched for HER-2/neu receptor negative breast cancer in clinical trials in the Philippines?
What are being researched for HER-2/neu receptor negative breast cancer in clinical trials in the Philippines?
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What type of cancer is Bevacizumab used for?
What type of cancer is Bevacizumab used for?
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Which drug is used for acute lymphoblastic leukemia to deplete serum asparagine?
Which drug is used for acute lymphoblastic leukemia to deplete serum asparagine?
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Which drug inhibits DNA topoisomerase II and mitochondrial electron transport?
Which drug inhibits DNA topoisomerase II and mitochondrial electron transport?
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Which drug acts against breast cancer cells that overexpress the HER-2/neu receptor?
Which drug acts against breast cancer cells that overexpress the HER-2/neu receptor?
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Which drug intercalates between base pairs and inhibits topoisomerase II?
Which drug intercalates between base pairs and inhibits topoisomerase II?
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Which drug generates free radicals, causing DNA strand breaks?
Which drug generates free radicals, causing DNA strand breaks?
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Which drug prevents microtubule assembly?
Which drug prevents microtubule assembly?
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Which drug inhibits tyrosine kinase activity?
Which drug inhibits tyrosine kinase activity?
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Which drug interferes with mitotic spindle and prevents microtubule disassembly?
Which drug interferes with mitotic spindle and prevents microtubule disassembly?
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Which drug inhibits DNA topoisomerase I?
Which drug inhibits DNA topoisomerase I?
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Which drug is a pyrimidine metabolite that inhibits DNA synthesis and repair?
Which drug is a pyrimidine metabolite that inhibits DNA synthesis and repair?
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Which drug is a camptothecin that inhibits DNA topoisomerase I?
Which drug is a camptothecin that inhibits DNA topoisomerase I?
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Which drug binds to double-stranded DNA and inhibits DNA-dependent RNA synthesis?
Which drug binds to double-stranded DNA and inhibits DNA-dependent RNA synthesis?
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Which drug is a vinca alkaloid that prevents microtubule assembly?
Which drug is a vinca alkaloid that prevents microtubule assembly?
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Which drug is used for choriocarcinoma, acute leukemias, and breast cancer?
Which drug is used for choriocarcinoma, acute leukemias, and breast cancer?
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Which drug is used for pancrea c cancer, non-small cell lung cancer, and bladder cancer?
Which drug is used for pancrea c cancer, non-small cell lung cancer, and bladder cancer?
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Which drug causes alopecia and skin rash, and is non-leukemogenic?
Which drug causes alopecia and skin rash, and is non-leukemogenic?
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Which drug is used for acute myeloid leukemia, with toxicities including bone marrow suppression and gastrointestinal irritation?
Which drug is used for acute myeloid leukemia, with toxicities including bone marrow suppression and gastrointestinal irritation?
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Which drug is a vinca alkaloid used for bladder cancer, breast cancer, and liver cancer?
Which drug is a vinca alkaloid used for bladder cancer, breast cancer, and liver cancer?
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Which drug is used for brain tumors, melanoma, and skin cancer, with toxicities including CNS toxicity, nausea, and bone marrow suppression?
Which drug is used for brain tumors, melanoma, and skin cancer, with toxicities including CNS toxicity, nausea, and bone marrow suppression?
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Which drug is used for Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and brain tumors, with toxicities like bone marrow suppression and pulmonary toxicity?
Which drug is used for Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and brain tumors, with toxicities like bone marrow suppression and pulmonary toxicity?
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Which drug is used for acute leukemias and chronic myelogenous leukemia, with toxicities including bone marrow suppression and hepatotoxicity?
Which drug is used for acute leukemias and chronic myelogenous leukemia, with toxicities including bone marrow suppression and hepatotoxicity?
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Which drug is used for acute leukemias, lymphomas, and Wilms tumor, with toxicities including areflexia and peripheral neuritis?
Which drug is used for acute leukemias, lymphomas, and Wilms tumor, with toxicities including areflexia and peripheral neuritis?
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Which drug is used for bladder cancer, breast cancer, and colorectal cancer, and it inhibits thymidylate synthase causing thymineless death of cells?
Which drug is used for bladder cancer, breast cancer, and colorectal cancer, and it inhibits thymidylate synthase causing thymineless death of cells?
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Which drug is used for chronic myelogenous leukemia, with toxicities including pulmonary fibrosis and skin pigmentation?
Which drug is used for chronic myelogenous leukemia, with toxicities including pulmonary fibrosis and skin pigmentation?
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Study Notes
Breast Cancer Treatment Options and Clinical Trials in the Philippines
- Breast cancer can be hormone sensitive or HER-2/neu sensitive
- Hormone-sensitive breast cancer is ideal for hormonal therapy with drugs like Tamoxifen, Raloxifene, and Letrozole
- Finding anti-cancer agents for Estrogen Receptor and Progesterone Receptor Negative breast cancers is challenging
- Trastuzumab is effective for HER-2/neu receptor positive breast cancer
- New monoclonal antibodies are being researched for HER-2/neu receptor negative breast cancer in clinical trials in the Philippines
- Stage/Phase IV clinical trials in the Philippines offer access to new drugs at lower prices
- Bevacizumab inhibits VEGF signaling and is used for various cancers
- Asparaginase depletes serum asparagine and is used for acute lymphoblastic leukemia
- All-trans-retinoic acid allows DNA transcription and differentiation of immature leukemic cells
- Rituximab is a monoclonal antibody used in Non-Hodgkin's lymphoma
- Prednisone suppresses inflammation and immune response and is used in leukemia and lymphomas
- Hormonal anticancer agents like Tamoxifen and Leuprolide have specific mechanisms of action and clinical uses
Antineoplastic Drugs Summary
- Carmustine is an alkylating agent used for brain tumors, melanoma, and skin cancer, with toxicities including CNS toxicity, nausea, and bone marrow suppression
- Lomustine, a nitrosourea alkylating agent, is used for Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and brain tumors, with toxicities like bone marrow suppression and pulmonary toxicity
- Dacarbazine is an antimetabolite used for Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and brain tumors, causing alopecia and skin rash, and it is non-leukemogenic
- Methotrexate, an antimetabolite, is used for Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and brain tumors, with toxicities including alopecia, skin rash, and bone marrow suppression
- Busulfan, an alkylating agent, is used for choriocarcinoma, acute leukemias, and breast cancer, with toxicities like bone marrow suppression and pulmonary infiltrates
- Procarbazine, an alkylating agent, is used for chronic myelogenous leukemia, with toxicities including pulmonary fibrosis and skin pigmentation
- 6-Mercaptopurine, an antimetabolite, is used for acute leukemias and chronic myelogenous leukemia, with toxicities including bone marrow suppression and hepatotoxicity
- Gemcitabine, an antimetabolite, is used for pancrea c cancer, non-small cell lung cancer, and bladder cancer, with toxicities like bone marrow suppression and pulmonary toxicity
- Vincristine, a vinca alkaloid, is used for acute leukemias, lymphomas, and Wilms tumor, with toxicities including areflexia and peripheral neuritis
- 5-Fluorouracil, an antimetabolite, is used for bladder cancer, breast cancer, and colorectal cancer, and it inhibits thymidylate synthase causing thymineless death of cells
- Vinblastine, a vinca alkaloid, is used for bladder cancer, breast cancer, and liver cancer, with toxicities including bone marrow suppression and alopecia
- Cytarabine, an antimetabolite, is used for acute myeloid leukemia, with toxicities including bone marrow suppression and gastrointestinal irritation
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Description
Test your knowledge of breast cancer treatment options and clinical trials in the Philippines with this quiz. Explore hormone-sensitive and HER-2/neu sensitive breast cancer treatments, including monoclonal antibodies and anti-cancer agents. Gain insights into stage/phase IV clinical trials and access to new drugs. Learn about antineoplastic drugs, their uses, and toxicities.
