Blood Groups and Immunology Quiz

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Questions and Answers

What is the main characteristic that determines a person's blood group in the ABO system?

  • The presence or absence of specific glycolipid antigens on the surface of red blood cells (correct)
  • The presence of specific enzymes within the red blood cells
  • The presence of specific proteins on the surface of red blood cells
  • The specific type of antibodies present in the plasma

Which blood group is considered the 'universal donor' due to the lack of antigens that could trigger an immune response in the recipient?

  • A+
  • O- (correct)
  • O+
  • AB+

What is a potential consequence of a mismatch in blood groups during a transfusion?

  • Increased blood clotting
  • Reduced oxygen carrying capacity
  • Destruction of recipient's red blood cells by antibodies (correct)
  • Increased risk of infection

How are anti-Rhesus antibodies formed in Rh-negative individuals?

<p>They are produced by the immune system in response to exposure to Rh-positive blood. (D)</p> Signup and view all the answers

Which of the following scenarios is most likely to lead to the development of haemolytic disease of the newborn?

<p>An Rh-negative mother carrying an Rh-positive baby (C)</p> Signup and view all the answers

What is the primary function of neutrophils?

<p>Ingest and destroy microbes. (B)</p> Signup and view all the answers

What is the correct term for the process by which neutrophils engulf and destroy microbes?

<p>Phagocytosis (C)</p> Signup and view all the answers

Which of the following is NOT a mechanism used by neutrophils to combat infection?

<p>Release of histamine (A)</p> Signup and view all the answers

Which blood group is considered the universal donor?

<p>O- (D)</p> Signup and view all the answers

Which of the following is a true statement about anti-D antibodies?

<p>They can be administered medically to prevent Rh incompatibility. (D)</p> Signup and view all the answers

What is the primary component of blood plasma?

<p>Water (A)</p> Signup and view all the answers

Which plasma protein is primarily responsible for maintaining osmotic pressure?

<p>Albumin (D)</p> Signup and view all the answers

What nutrient primarily carried by blood plasma serves as a building block for proteins?

<p>Amino acids (C)</p> Signup and view all the answers

Which of the following cations is NOT found in blood plasma?

<p>Iron (C)</p> Signup and view all the answers

Where are the majority of plasma proteins synthesized?

<p>Liver cells (D)</p> Signup and view all the answers

What is the primary function of erythrocytes?

<p>To transport respiratory gases (D)</p> Signup and view all the answers

What is the maximum number of oxygen molecules that one haemoglobin molecule can carry?

<p>4 (D)</p> Signup and view all the answers

Which components make up adult haemoglobin (HbA)?

<p>Two alpha and two beta subunits (C)</p> Signup and view all the answers

What occurs to erythrocytes as they mature from their immature state?

<p>They lose their nuclei and organelles (A)</p> Signup and view all the answers

What causes blood to appear red?

<p>The interaction of iron and oxygen within haem units (C)</p> Signup and view all the answers

What is the range of hemoglobin concentration in a healthy pregnant woman?

<blockquote> <p>11 g/dL (B)</p> </blockquote> Signup and view all the answers

Which of the following is NOT a general sign or symptom of anemia?

<p>Increased appetite (A)</p> Signup and view all the answers

Iron deficiency anemia is characterized by:

<p>Hypochromic microcytic anemia (B)</p> Signup and view all the answers

Which of the following is NOT a cause of iron deficiency anemia?

<p>Vitamin B12 deficiency (D)</p> Signup and view all the answers

What is a potential sign of iron deficiency anemia that can be observed in the nails?

<p>Koilonychia (C)</p> Signup and view all the answers

Where does haematopoiesis primarily occur in adults?

<p>Bone marrow (D)</p> Signup and view all the answers

Which of the following herbs is suggested as a natural remedy for iron deficiency anemia?

<p>Yellow dock (B)</p> Signup and view all the answers

Which of the following is NOT a waste product found in blood plasma?

<p>Glucose (C)</p> Signup and view all the answers

What is the medical term for an abnormally low red blood cell count?

<p>Erythropenia (D)</p> Signup and view all the answers

What is the approximate lifespan of an erythrocyte?

<p>90-120 days (A)</p> Signup and view all the answers

Which of the following is NOT part of a natural approach to address iron deficiency anemia?

<p>Antibiotics (C)</p> Signup and view all the answers

Which of the following is NOT a site of haematopoiesis in the adult body?

<p>Spleen (B)</p> Signup and view all the answers

What is the role of thrombin in blood clotting?

<p>Thrombin converts fibrinogen into fibrin, forming a mesh that traps blood cells. (A)</p> Signup and view all the answers

Which of the following is NOT a natural anti-coagulant produced by the body?

<p>Warfarin (D)</p> Signup and view all the answers

What is the primary function of plasmin in the blood clotting process?

<p>Plasmin dissolves fibrin clots by digesting fibrin threads and inactivating clotting factors. (C)</p> Signup and view all the answers

Which of the following is a source of vitamin Kâ‚‚?

<p>Fermented foods like natto (C)</p> Signup and view all the answers

Which of the following is an example of an anti-coagulant herb?

<p>Ginger (B)</p> Signup and view all the answers

From what type of cell do thrombocytes (platelets) develop?

<p>Megakaryoblasts (D)</p> Signup and view all the answers

Where are thrombocytes produced?

<p>Red bone marrow (C)</p> Signup and view all the answers

What is the lifespan of a thrombocyte?

<p>10 days (C)</p> Signup and view all the answers

What is the primary function of thrombocytes?

<p>Form blood clots and prevent blood loss (C)</p> Signup and view all the answers

What substance is released by activated platelets to initiate clotting?

<p>Thromboxane (C)</p> Signup and view all the answers

What is the first stage of blood clotting?

<p>Vasoconstriction (C)</p> Signup and view all the answers

What is the immediate consequence of platelet activation?

<p>Release of clotting factors (C)</p> Signup and view all the answers

What is the primary function of monocytes when in tissue?

<p>Engage in phagocytosis and activate other immune cells (C)</p> Signup and view all the answers

What is the main mode of action of basophils?

<p>Release histamine and heparin to enhance inflammation (C)</p> Signup and view all the answers

Which leukocyte type is primarily responsible for eliminating parasites?

<p>Eosinophils (B)</p> Signup and view all the answers

What role do T-lymphocytes play in the immune response?

<p>Kill invading pathogens and activate other immune cells (D)</p> Signup and view all the answers

Which leukocyte type is NOT phagocytic?

<p>Basophils (D)</p> Signup and view all the answers

What stimulates the secretion of erythropoietin (EPO)?

<p>Hypoxia (B)</p> Signup and view all the answers

Where is bilirubin predominantly formed in the body?

<p>Spleen, bone marrow, and liver (D)</p> Signup and view all the answers

What is the main role of macrophages in the process of haemolysis?

<p>To destroy erythrocytes (C)</p> Signup and view all the answers

What must happen to unconjugated bilirubin in order for it to be effectively excreted?

<p>It must be conjugated in the liver (B)</p> Signup and view all the answers

What is a common consequence of haemolysis in the body?

<p>Formation of bilirubin (A)</p> Signup and view all the answers

Flashcards

What is blood plasma?

The liquid component of blood containing substances like waste products, hormones, enzymes, and gases.

What is hematopoiesis?

The process of creating all types of blood cells.

What are erythrocytes?

Bi-concave, non-nucleated cells responsible for oxygen transport.

What are leukocytes?

White blood cells involved in the immune system.

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What are thrombocytes?

Small cell fragments responsible for blood clotting.

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What is Albumin and its function?

The smallest and most abundant plasma protein, albumin plays a key role in maintaining osmotic pressure, which regulates fluid balance within blood vessels. It also acts as a carrier for substances like lipids and hormones.

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What are Globulins and their roles?

Globulins are a diverse group of plasma proteins involved in immune responses and transport. They help your body fight infections (immunoglobulins/antibodies) and carry iron, lipids, and vitamins.

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What is Fibrinogen and its importance?

Fibrinogen is a crucial protein for blood clotting. It transforms into fibrin, forming a mesh-like structure that traps blood cells to stop bleeding.

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What nutrients are transported by Blood Plasma?

Blood plasma carries nutrients from digestion to all body cells, including simple sugars (glucose), amino acids (building blocks of proteins), fats/oils, and vitamins.

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Anti-D antibodies

A type of antibody that binds to and inactivates Rh antigens from fetal red blood cells.

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Phagocytosis

The process of ingesting and destroying microbes by immune cells.

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Reactive Oxygen Species (ROS)

Highly reactive molecules produced by neutrophils to combat infection.

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Neutrophil Migration

The movement of neutrophils to the site of infection.

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Neutrophils

The most abundant type of white blood cells, responsible for phagocytosing and destroying microbes.

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What are red blood cells for?

Red blood cells, also known as erythrocytes, primarily carry oxygen and a small amount of carbon dioxide throughout the body.

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How many haemoglobin molecules are in one red blood cell?

Each red blood cell contains 280 million haemoglobin molecules, which bind to oxygen and allow for its transport in the blood.

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What is haemoglobin?

Haemoglobin, a protein responsible for oxygen transport, consists of four polypeptide chains. The specific arrangement of these chains varies between fetal and adult haemoglobin.

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What is erythropoiesis?

The process of red blood cell formation, taking place in the red bone marrow.

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Why is human blood red?

The iron within the haem group of haemoglobin is responsible for the red color of blood. The interaction of iron and oxygen affects how light is reflected, giving blood its characteristic red hue.

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Erythropoiesis

The process of red blood cell production, stimulated by the hormone erythropoietin (EPO).

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Haemolysis

The breakdown of red blood cells, releasing hemoglobin into the blood plasma.

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Erythropoietin (EPO)

A hormone produced by the kidneys, mainly in response to low oxygen levels (hypoxia). It stimulates red blood cell production in the bone marrow.

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Bilirubin

A yellow pigment formed from the breakdown of heme, a component of hemoglobin. It's excreted in bile and urine.

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Bilirubin Conjugation

The liver's process of converting unconjugated bilirubin (formed during red blood cell breakdown) into a form that can be excreted in bile.

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What is antigen A?

A glycolipid antigen found on the surface of red blood cells, determining an individual's ABO blood group.

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What is blood group A?

Individuals with blood group A possess antigen A on their red blood cells and anti-B antibodies in their plasma.

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What is a transfusion reaction?

A transfusion reaction occurs when incompatible blood types are mixed, leading to the destruction of red blood cells.

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What is the universal donor?

Individuals with blood group O lack both A & B antigens, making them universal donors as their blood can be safely transfused to any recipient.

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What is the Rhesus (Rh) antigen?

The Rhesus (Rh) antigen is another surface antigen found on red blood cells, determining whether someone is Rh-positive or Rh-negative.

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What are macrophages?

Macrophages are white blood cells that engulf and destroy debris and pathogens in tissues. They also present antigens to activate other immune cells.

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What are eosinophils?

Eosinophils are white blood cells primarily involved in fighting parasitic infections and regulating allergic reactions.

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What are basophils?

Basophils are white blood cells containing histamine and heparin. They play a crucial role in inflammation, dilating blood vessels, and preventing blood clotting.

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What are B-lymphocytes?

B-lymphocytes are white blood cells that produce antibodies, proteins that recognize and neutralize specific pathogens.

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What are T-lymphocytes?

T-lymphocytes are white blood cells that directly kill infected cells or tumor cells, or activate other immune cells.

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How are thrombocytes produced?

Megakaryocytes are large cells that break down into fragments called thrombocytes. Thrombopoietin produced by the liver influences their formation.

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What do thrombocytes store?

Storage granules within thrombocytes contain proteins and adhesion molecules that are released when activated. These molecules initiate clotting and healing.

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What does thromboxane do?

Thromboxane, a vasoconstrictor, is released when thrombocytes are activated. It causes vascular spasms and promotes blood clot formation.

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What is vasoconstriction?

Vasoconstriction is the first step in clotting. Smooth muscle contracts, narrowing blood vessels when damaged.

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How is a platelet plug formed?

Platelet plug formation is the second step. Platelets stick to damaged blood vessels and aggregate, forming a plug to stop bleeding.

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What happens after platelet plug formation?

The final steps of clotting involve forming a mesh-like structure called a fibrin clot with the help of thrombin.

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What is the overall process of blood clotting?

Blood clotting is a complex process that involves steps like vasoconstriction, platelet plug formation, and fibrin mesh formation.

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What is fibrinolysis?

The process that involves the breakdown of a blood clot, typically by the enzyme plasmin, which digests fibrin threads, inactivating fibrinogen and thrombin.

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What is heparin?

A natural anti-coagulant produced in the body by mast cells and basophils, which prevents blood clots and promotes blood fluidity.

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What is Vitamin K?

A vitamin vital for the synthesis of clotting factors, helping the blood to clot effectively. It can be found in dark green vegetables, tomatoes and fermented foods like natto. It is also produced by your gut bacteria.

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What is fibrinogen and what is its function?

A crucial protein involved in the clotting process that transforms into long, sticky threads called fibrin. These threads create a mesh-like structure, trapping blood cells and forming a blood clot.

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What are anti-coagulants?

These are medications that can be prescribed to prevent blood clots from forming. One example is Warfarin, which acts by blocking the synthesis of vitamin K-dependent clotting factors.

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What is anemia?

Anemia is a condition characterized by lower than normal hemoglobin concentration in the blood, leading to reduced oxygen-carrying capacity.

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What is Iron-deficiency anemia?

Iron deficiency anemia is the most common type worldwide, with low iron levels impairing hemoglobin production, resulting in pale, small red blood cells.

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What are spoon-shaped nails?

Spoon-shaped nails, known as koilonychia, are a characteristic symptom of iron deficiency anemia.

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What is angular stomatitis?

Angular stomatitis, a painful cracking at the corners of the mouth, can occur due to iron deficiency anemia.

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What is glossitis?

Glossitis, inflammation of the tongue, is another symptom that can occur in iron deficiency anemia.

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What are the blood test indicators of iron deficiency anemia?

Low red blood cell count, low hemoglobin levels, and low ferritin (iron storage protein) are key blood test indicators of iron deficiency anemia.

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How can dietary intake prevent iron deficiency anemia?

Dietary intake of iron-rich foods like dark leafy greens is crucial for preventing iron deficiency anemia. Eating pumpkin and sunflower seeds, and consuming vitamin C can also help.

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What are the treatments for iron deficiency anemia?

Iron supplementation is often recommended to address iron deficiency anemia, along with treating any underlying causes like malabsorption or excessive blood loss.

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