Blood Functions and Plasma Composition

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Questions and Answers

Which of the following is a primary function of blood?

  • Filtering air for respiration
  • Transporting oxygen and carbon dioxide (correct)
  • Synthesizing hormones
  • Producing digestive enzymes

What role does blood play in regulating body temperature?

  • It insulates the body to prevent heat loss.
  • It absorbs heat from body cells and releases it at the skin. (correct)
  • It cools the body by producing sweat.
  • It generates heat through metabolic processes.

Which component makes up the highest percentage of blood plasma?

  • Proteins
  • Electrolytes
  • Water (correct)
  • Nutrients

What is the approximate percentage of blood volume made up by blood plasma?

<p>55% (D)</p> Signup and view all the answers

Which of the following electrolytes is found in blood plasma?

<p>Sodium (C)</p> Signup and view all the answers

Which enzyme initiates the digestion of starch in the mouth?

<p>Salivary amylase (C)</p> Signup and view all the answers

What is the name given to the mixture of food and gastric secretions in the stomach?

<p>Chyme (B)</p> Signup and view all the answers

Which organ stores, concentrates, and releases bile?

<p>Gallbladder (A)</p> Signup and view all the answers

What is the primary function of the large intestine?

<p>Water and electrolyte absorption (C)</p> Signup and view all the answers

Which of the following enzymes is responsible for breaking down proteins into smaller peptides in the stomach?

<p>Pepsin (A)</p> Signup and view all the answers

Which of the following is NOT produced by the pancreas?

<p>Bile (C)</p> Signup and view all the answers

Which of the following is the function of hydrochloric acid (HCl) in the stomach?

<p>Activating pepsin (D)</p> Signup and view all the answers

What is the role of bile in digestion?

<p>Emulsifies fats (D)</p> Signup and view all the answers

Where does the majority of nutrient absorption take place?

<p>Small intestine (D)</p> Signup and view all the answers

Which enzyme breaks down fats into glycerol and fatty acids?

<p>Lipase (B)</p> Signup and view all the answers

Which plasma protein group is the smallest and most abundant?

<p>Albumins (D)</p> Signup and view all the answers

What is the key function of fibrinogen?

<p>Blood clotting (C)</p> Signup and view all the answers

Which hormone causes more erythropoietin secretion by the kidney?

<p>Testosterone (B)</p> Signup and view all the answers

What is the primary function of red blood cells?

<p>Transporting oxygen and carbon dioxide (C)</p> Signup and view all the answers

Why do red blood cells lack a nucleus?

<p>To increase flexibility and space for hemoglobin (D)</p> Signup and view all the answers

What metal is at the center of the heme group in hemoglobin?

<p>Iron (A)</p> Signup and view all the answers

Which type of white blood cell is the most abundant?

<p>Neutrophils (D)</p> Signup and view all the answers

What is the function of B cells?

<p>Producing antibodies (D)</p> Signup and view all the answers

Which blood type is considered the universal recipient?

<p>Type AB (B)</p> Signup and view all the answers

What is the first phase in response to blood vessel injury?

<p>Vascular spasm (D)</p> Signup and view all the answers

What antigens does Type O blood have?

<p>No A or B antigens (C)</p> Signup and view all the answers

What causes greater vasoconstriction?

<p>Major vessel damage (D)</p> Signup and view all the answers

What happens during hemolysis in an incompatible blood transfusion?

<p>Red blood cells are destroyed (D)</p> Signup and view all the answers

What helps platelets adhere to collagen upon damage to blood vessel endothelium?

<p>Von Willebrand factor (VWF) (A)</p> Signup and view all the answers

What is agglutination?

<p>The clumping of blood cells due to antibodies. (B)</p> Signup and view all the answers

What limits the platelet plug?

<p>PGI2 (D)</p> Signup and view all the answers

What molecule does hemoglobin transport?

<p>Oxygen and carbon dioxide (D)</p> Signup and view all the answers

What causes the biconcave disc shape of red blood cells?

<p>Absence of a nucleus and organelles (D)</p> Signup and view all the answers

What is the final product of blood clotting?

<p>Fibrin mesh (C)</p> Signup and view all the answers

What role do monocytes play in the immune system?

<p>Becoming macrophages and engulfing pathogens (C)</p> Signup and view all the answers

What is the enzyme responsible for breaking down a clot?

<p>Plasmin (B)</p> Signup and view all the answers

What is the inactive enzyme that is converted to plasmin?

<p>Plasminogen (D)</p> Signup and view all the answers

What do you call smaller fragments that plasmin breaks down?

<p>Fibrin degradation products (FDPs) (A)</p> Signup and view all the answers

What promotes tissue repair?

<p>Fibrin mesh (B)</p> Signup and view all the answers

What do you call a stationary clot within a blood vessel?

<p>Thrombus (B)</p> Signup and view all the answers

What removes remaining fragments from a blood clot?

<p>Macrophages (C)</p> Signup and view all the answers

What is the introduction of solid and liquid nurtients into the oral cavity?

<p>Ingestion (C)</p> Signup and view all the answers

What do you call breaking down food into smaller pieces, without changing the chemical compositions?

<p>Mechanical digestion (D)</p> Signup and view all the answers

What is the movement of digested molecules from the GI tract into blood or lymph?

<p>Absorption (C)</p> Signup and view all the answers

What do you call the removal of undigested food and waste?

<p>Excretion (A)</p> Signup and view all the answers

Flashcards

Functions of Blood

The primary roles of blood include transport, regulation, fluid balance, and protection.

Transport Function

Blood carries oxygen, carbon dioxide, nutrients, hormones, heat, and waste products.

Blood Plasma Composition

Blood plasma is about 90-92% water and 8-10% dissolved substances, including electrolytes, nutrients, and waste.

Osmotic Pressure Proteins

Proteins like albumin in plasma help maintain osmotic pressure and fluid balance in the blood.

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Key Blood Proteins

Important proteins in blood plasma include albumin, fibrinogen, and immunoglobulins for clotting and immunity.

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Salivary Amylase

Enzyme in saliva that starts starch digestion.

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Bolus

A mass of food formed in the mouth for swallowing.

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Chyme

Semi-liquid mixture of food and gastric juices in the stomach.

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Duodenum

First part of the small intestine where most digestion occurs.

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Gallbladder

Stores and concentrates bile from the liver.

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Pancreas

Produces digestive enzymes and hormones like insulin.

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Pepsin

Enzyme in the stomach that breaks down proteins.

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Small Intestine

Primary site for nutrient absorption and digestion.

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Bile

Digestive fluid produced by the liver that emulsifies fats.

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Large Intestine

Absorbs water and compacts waste into feces.

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Albumins

Smallest and most abundant plasma proteins (58%), crucial for osmotic pressure.

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Fibrinogen

Key plasma protein involved in blood clotting process.

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Hematocrit

Percentage of blood volume made up of red blood cells.

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Red Blood Cells

Small, flexible cells without a nucleus, packed with hemoglobin for gas transport.

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Hemoglobin

Red protein in RBCs that transports oxygen and carbon dioxide.

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Oxygen Transport

Process where RBCs carry oxygen from lungs to tissues.

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Carbon Dioxide Transport

RBCs transport CO2 from tissues to lungs for expulsion.

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pH Regulation

RBCs help maintain blood pH by buffering hydrogen ions.

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Neutrophils

Most abundant WBCs that fight bacterial and fungal infections.

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Lymphocytes

WBCs that include B cells and T cells for antibody production and attack.

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Blood Type A

Red blood cells have A antigens and produce anti-B antibodies.

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Universal Donor

Blood type O has no A or B antigens and can donate to any type.

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Incompatible Transfusion

Occurs when the wrong blood type is given, leading to immune reaction.

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Agglutination

Clumping of red blood cells due to antibodies binding to foreign cells.

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Clotting Cascade

Series of chemical reactions that lead to blood clot formation.

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Vascular Spasm

Constricted blood vessels that limit blood loss after injury.

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Platelet Plug Formation

Platelets adhere to exposed collagen, forming a plug at injury sites.

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Von Willebrand Factor (VWF)

A protein that helps platelets adhere to damaged blood vessels.

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Thromboxane A2

A chemical released by activated platelets that stimulates further platelet aggregation.

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Coagulation

The process of blood transforming from liquid to gel, forming a clot.

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Fibrin Mesh

A network of fibers that stabilizes a blood clot and prevents excessive bleeding.

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Fibrinolysis

The process of breaking down a blood clot after it has fulfilled its function.

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Plasminogen

An inactive enzyme incorporated into clots that gets activated to dissolve clots.

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Deep Vein Thrombosis (DVT)

A blood clot that forms in deep veins, often of the legs.

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Pulmonary Embolism (PE)

A clot that travels to the lungs, blocking blood flow.

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Thrombosis

Undesirable clot formation within blood vessels without injury.

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Risk Factors for Thrombosis

Conditions that increase the likelihood of unwanted blood clots.

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Compression Therapy

Use of compression stockings to improve leg circulation and prevent clots.

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Blood Thinners

Medications that reduce blood clotting risk, like heparin and warfarin.

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Macrophages

Immune cells that help clear out clot fragments after fibrinolysis.

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Study Notes

Blood Functions

  • Transports formed elements, dissolved molecules, and ions
    • Carries oxygen to and carbon dioxide from the lungs
    • Transports nutrients, hormones, heat, and waste products (e.g., carbon dioxide, urea)
  • Regulates body conditions
    • Body temperature: Absorbs heat; releases heat at skin blood vessels.
    • Body pH: Absorbs acids and bases; contains chemical buffers (e.g., bicarbonate).
    • Fluid balance: Adds water from the GI tract; loses water in urine, skin, and respiration; exchanges fluid with interstitial fluid, maintains osmotic balance with proteins and ions.
  • Protects against pathogens: Leukocytes, plasma proteins, and other immune system molecules.
  • Protects against blood loss: Platelets and plasma proteins.

Definition of Hematocrit- Percentage of volume of all formed elements • Clinical definition of Hematocrit: percentage of only erythrocytes

Blood Plasma

  • Accounts for ~55% of blood volume.
  • Liquid component transporting various substances.
  • Composition:
    • Mostly water (~90-92%)
    • Dissolved substances (8-10%): Electrolytes (Na+, K+, Ca2+, Cl-, HCO3-), nutrients, waste products (urea, creatinine, uric acid), hormones, and gases (O2, CO2, N2).

Important Blood Proteins

  • Albumins: Smallest and most abundant (58%), exert significant colloid osmotic pressure, and transport lipids, hormones, and ions.
  • Fibrinogen: Key protein in blood clotting.

Red Blood Cells (Erythrocytes)

  • Small, flexible, biconcave discs.
  • Lack nucleus and organelles, packed with hemoglobin.
  • Transport oxygen and carbon dioxide.
  • Why lack a nucleus?
    • More hemoglobin capacity.
    • Flexible shape for capillary passage.
    • Efficient gas exchange.
    • Increased lifespan (120 days) because they don't need to use oxygen internally.
  • Hemoglobin:
    • Red-pigmented protein.
    • Transports oxygen and carbon dioxide (oxygenated/deoxygenated forms).
    • Composed of four globins (two alpha, two beta chains), each with a heme group containing iron.
    • Oxygen binds to iron.

White Blood Cells (Leukocytes)

  • Part of the immune system, defending against infections and abnormal cells.
  • Have a nucleus, different types with specific functions:
    • Neutrophils: Fight bacterial/fungal infections.
    • Lymphocytes: Include B cells (antibodies), and T cells (attack infected/cancerous cells).
    • Monocytes: Become macrophages engulfing pathogens and dead cells.
    • Eosinophils: Fight parasites and have a role in allergic reactions.
    • Basophils: Release histamine in allergic responses.

Blood Types and Compatibility

  • Determined by antigens (A, B, Rh) on red blood cells.
  • Types: A, B, AB, O.
  • Rh factor (+/-)
  • Incompatible transfusion causes hemolysis (RBC destruction), agglutination (clumping), leading to serious reactions in the recipient.
  • Careful cross-matching is essential before transfusions.

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