Blood Composition and Functions Quiz

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary mechanism by which drugs like tPA and streptokinase dissolve clots?

  • By directly breaking down fibrinogen into smaller peptides.
  • By chelating calcium ions, which are essential for coagulation.
  • By activating plasmin to dissolve clots. (correct)
  • By inhibiting the production of prothrombin in the liver.

In thrombocytopenia, what is the typical impact on an individual's health?

  • Impaired liver function leading to a deficiency in clotting factors.
  • Overproduction of erythrocytes, resulting in polycythemia.
  • Excessive bleeding and bruising due to a reduced number of platelets. (correct)
  • Increased risk of arterial thrombosis due to elevated platelet aggregation.

Why does impaired liver function contribute to bleeding disorders?

  • The liver synthesizes most procoagulants, and liver disease leads to their deficiency. (correct)
  • The liver produces bile, essential for the absorption of iron necessary for hemoglobin synthesis.
  • The liver filters platelets from the blood, and its impairment leads to thrombocytopenia.
  • The liver is the primary site for red blood cell production, and its impairment leads to anemia.

What is the underlying cause of hemophilia A?

<p>A deficiency in factor VIII, leading to impaired activation of the intrinsic pathway. (C)</p> Signup and view all the answers

How does the body initially compensate for blood loss to maintain blood pressure and circulation?

<p>Increasing heart rate and generalized vasoconstriction. (C)</p> Signup and view all the answers

Which enzyme directly facilitates the breakdown of fibrin during fibrinolysis?

<p>Plasmin (D)</p> Signup and view all the answers

What is the primary source of tissue plasminogen activator (tPA) that initiates fibrinolysis?

<p>Endothelial Cells (D)</p> Signup and view all the answers

How does antithrombin III limit clot growth?

<p>By inactivating thrombin and other procoagulants. (A)</p> Signup and view all the answers

What role does heparin play in limiting clot formation?

<p>It enhances the activity of antithrombin III. (B)</p> Signup and view all the answers

Which of the following factors prevents undesirable clotting in intact blood vessels?

<p>Smooth endothelial lining and endothelial-derived nitric oxide and prostacyclin (C)</p> Signup and view all the answers

What is a 'thrombus'?

<p>A clot that develops and persists in an unbroken blood vessel. (B)</p> Signup and view all the answers

Which of the following is an example of a thromboembolic condition?

<p>Development of a thrombus in an unbroken blood vessel (C)</p> Signup and view all the answers

What is the primary function of the chordae tendineae and papillary muscles in relation to the heart valves?

<p>To ensure unidirectional blood flow by preventing the atrioventricular valves from inverting during ventricular contraction. (C)</p> Signup and view all the answers

How does the body ensure that clot formation is localized and doesn't spread excessively?

<p>By swift removal of coagulation factors and inhibition of activated clotting factors. (B)</p> Signup and view all the answers

Which valve is located between the right atrium and the right ventricle?

<p>Tricuspid valve (A)</p> Signup and view all the answers

What is the destination of blood that passes through the pulmonary valve?

<p>Pulmonary trunk (A)</p> Signup and view all the answers

Which of the following is a characteristic of valvular stenosis?

<p>Stiff valves due to calcification or scar tissue. (A)</p> Signup and view all the answers

Which heart valve is also known as the bicuspid valve?

<p>Mitral valve (A)</p> Signup and view all the answers

What is the direct consequence of valvular insufficiency?

<p>Backflow of blood due to incomplete valve closure. (B)</p> Signup and view all the answers

Why is the left ventricle wall significantly thicker than the right ventricle wall?

<p>To overcome the 5X higher resistance of the long systemic circuit. (C)</p> Signup and view all the answers

Which circuit has a shorter pathway and operates under lower pressure?

<p>The pulmonary circuit (D)</p> Signup and view all the answers

Why is type O blood considered the universal donor?

<p>It lacks A and B antigens on the red blood cells, minimizing the risk of agglutination in recipients. (C)</p> Signup and view all the answers

Why does transfusion of incompatible blood lead to potentially fatal consequences?

<p>The recipient's antibodies cause agglutination and hemolysis of the donor's red blood cells. (A)</p> Signup and view all the answers

Why are Rh- individuals typically not born with Rh antibodies in their blood?

<p>Rh antibodies are only produced in response to exposure to Rh antigens. (B)</p> Signup and view all the answers

How does RhoGAM prevent erythroblastosis fetalis in Rh- mothers carrying an Rh+ fetus?

<p>It contains anti-Rh antibodies that bind to and destroy fetal Rh+ red blood cells in the mother's circulation, preventing sensitization. (D)</p> Signup and view all the answers

What is the primary reason the recipient's agglutinins (antibodies) pose a greater risk in transfusion reactions than the donor's?

<p>Donor agglutinins are present in such small quantities that they are quickly diluted in the recipient's circulation. (C)</p> Signup and view all the answers

What is the primary danger associated with hemoglobin (Hb) precipitation and clogging of kidney tubules following a blood transfusion reaction?

<p>Possible kidney failure. (A)</p> Signup and view all the answers

In the context of blood typing, what is the purpose of using serum containing anti-A or anti-B agglutinins?

<p>To identify the presence of A or B antigens on red blood cells. (D)</p> Signup and view all the answers

Which of the following best describes the location of the heart within the thorax?

<p>Within the mediastinum, extending from the 2nd rib to the 5th intercostal space, with most of its mass on the left side. (C)</p> Signup and view all the answers

What is the primary function of the fibrous pericardium?

<p>Protecting, anchoring the heart and preventing overfilling. (C)</p> Signup and view all the answers

What is the epicardium also known as?

<p>Visceral Layer of the Serous Pericardium (A)</p> Signup and view all the answers

What is a key strategy to mitigate kidney failure following a blood transfusion reaction?

<p>Administering alkaline fluids and diuretics. (C)</p> Signup and view all the answers

Where is the heart located?

<p>Enclosed within the mediastinum of the thorax. (B)</p> Signup and view all the answers

What is autologous transfusion?

<p>Re-infusion of a patient's own blood (C)</p> Signup and view all the answers

What is the primary function of the myocardium?

<p>To generate the contractile force that pumps blood throughout the body. (C)</p> Signup and view all the answers

Which of the following structures is directly continuous with the endothelium of blood vessels entering and leaving the heart?

<p>Endocardium (C)</p> Signup and view all the answers

What is the role of the connective tissue wrappings within the myocardium?

<p>To reinforce the myocardium, anchor cardiac muscle fibers, support vessels and valves, and direct the spread of action potentials. (A)</p> Signup and view all the answers

Which of the following vessels delivers deoxygenated blood from the myocardium itself to the right atrium?

<p>Coronary sinus (D)</p> Signup and view all the answers

What is the primary function of the atria?

<p>To receive blood from the systemic and pulmonary circulations. (C)</p> Signup and view all the answers

Which feature is characteristic of the ventricles compared to the atria?

<p>Thicker walls adapted for pumping blood. (B)</p> Signup and view all the answers

What is the function of the left ventricle?

<p>Pumps oxygenated blood to the aorta. (C)</p> Signup and view all the answers

Which of the following structures are internal muscular bundles found in the ventricles?

<p>Trabeculae carneae (C)</p> Signup and view all the answers

Flashcards

Embolus

A blood clot that breaks free and travels through the bloodstream, potentially getting stuck in a smaller vessel.

Thrombocytopenia

A condition where there are too few platelets in the blood, making it difficult to form clots.

Hemophilia

A hereditary bleeding disorder caused by a deficiency in specific clotting factors in the intrinsic pathway. Hemophilia A lacks factor VIII, while Hemophilia B lacks factor IX.

Rh factor

A protein found on the surface of red blood cells. Individuals with the Rh factor are Rh positive, while those without it are Rh negative.

Signup and view all the flashcards

Transfusion Reaction

A reaction that occurs when incompatible blood types are mixed, causing agglutination (clumping) of red blood cells due to the presence of antibodies.

Signup and view all the flashcards

Rh blood group system

The blood group system based on the presence or absence of Rh antigens, primarily the D antigen. Approximately 85% of North Americans are Rh+ (meaning they have the D antigen) and 15% are Rh- (meaning they lack the D antigen).

Signup and view all the flashcards

Agglutinins

The antibodies responsible for attacking foreign red blood cells in a transfusion reaction. They are produced by the recipient's immune system in response to exposure to foreign red blood cells.

Signup and view all the flashcards

Erythroblastosis fetalis

A condition where an Rh- mother carrying an Rh+ fetus develops antibodies against the fetus's Rh+ blood cells, leading to potential hemolytic disease of the newborn (HDN).

Signup and view all the flashcards

Rh sensitization

The condition where Rh- individuals develop antibodies against Rh+ red blood cells after exposure to Rh antigens, either through a blood transfusion or carrying an Rh+ fetus.

Signup and view all the flashcards

Myocardium

The thick layer of muscle tissue composing the heart, responsible for pumping blood.

Signup and view all the flashcards

Cardiac Muscle Bundles

Branching cardiac muscle cells, bound together by connective tissue, giving strength and structure to the myocardium.

Signup and view all the flashcards

Endocardium

The innermost layer of the heart, composed of endothelium and connective tissue, lining its inner surface.

Signup and view all the flashcards

Atria

The two upper chambers of the heart, receiving blood from the body and lungs.

Signup and view all the flashcards

Ventricles

The two lower chambers of the heart, responsible for pumping blood out to the body and lungs.

Signup and view all the flashcards

Interatrial Septum

The wall separating the right and left atria.

Signup and view all the flashcards

Interventricular Septum

The wall separating the right and left ventricles.

Signup and view all the flashcards

Trabeculae carneae

Muscle bundles found within the ventricles, responsible for pumping blood.

Signup and view all the flashcards

Fibrinolysis

The process of dissolving a blood clot, typically starting at the edges and continuing until the clot is completely dissolved.

Signup and view all the flashcards

Plasmin

The enzyme that breaks down fibrin, which is a key protein in blood clots

Signup and view all the flashcards

Plasminogen

A plasma protein which is converted to plasmin by tissue plasminogen activator (tPA) during fibrinolysis.

Signup and view all the flashcards

Tissue Plasminogen Activator (tPA)

A protein secreted by endothelial cells that activates plasminogen, facilitating clot breakdown.

Signup and view all the flashcards

Thrombus

A clot that develops and persists in an unbroken blood vessel. These clots can block blood flow to vital tissues.

Signup and view all the flashcards

Thromboembolytic condition

The condition of undesirable intravascular clotting within blood vessels, potentially leading to blockage and tissue damage.

Signup and view all the flashcards

Swift removal of coagulation factors

A specific factor that plays a role in controlling the size of blood clots. It acts to remove procoagulants from the blood, limiting clot growth.

Signup and view all the flashcards

Inhibition of activated clotting factors

A type of factor that limits the size of blood clots by suppressing the activity of activated clotting factors.

Signup and view all the flashcards

Blood Agglutination: Reduced O2-Carrying Ability

Reduced oxygen-carrying capacity of blood due to clumped red blood cells.

Signup and view all the flashcards

Blood Agglutination: Clogging of Small Blood Vessels

Clogging of small blood vessels due to clumped red blood cells.

Signup and view all the flashcards

Blood Agglutination: Red Blood Cell Rupture

Rupture or destruction of clumped red blood cells by phagocytes, releasing free hemoglobin.

Signup and view all the flashcards

Blood Agglutination: Hemoglobin Precipitation in Kidneys

Precipitation of hemoglobin in kidney tubules, potentially leading to kidney failure.

Signup and view all the flashcards

Pericardium

The outer covering of the heart, composed of a double-walled, fibro-serous sac.

Signup and view all the flashcards

Fibrous Pericardium

The fibrous layer of the pericardium, providing protection and anchoring.

Signup and view all the flashcards

Serous Pericardium

The serous layer of the pericardium, composed of parietal and visceral (epicardium) layers, containing fluid-filled pericardial cavity.

Signup and view all the flashcards

Heart Valves

The structures that prevent backflow of blood through heart chambers. These structures ensure unidirectional blood flow within the heart, ensuring oxygenated blood is directed to the body and deoxygenated blood is sent to the lungs.

Signup and view all the flashcards

Atrioventricular (AV) Valves

Two valves that control blood flow between the atria and ventricles of the heart. They ensure the forward flow of blood from the atria to the ventricles.

Signup and view all the flashcards

Semilunar Valves

Two valves that regulate the flow of blood from the ventricles to the pulmonary and systemic circulations. They prevent the backflow of blood from the arteries back into the ventricles.

Signup and view all the flashcards

Chordae Tendineae

The strong fibrous cords that attach to the AV valve cusps and connect to papillary muscles within the ventricle. These cords prevent the valves from prolapsing or flipping back into the atria during ventricular contraction.

Signup and view all the flashcards

Valvular Insufficiency (Incompetent Valves)

A specific condition in which heart valves fail to close properly, allowing for blood to leak backward. This leads to inefficient blood flow.

Signup and view all the flashcards

Valvular Stenosis

A condition where heart valves become stiff and rigid due to calcium buildup or scarring, restricting blood flow. This can lead to reduced blood flow through the heart.

Signup and view all the flashcards

Pulmonary Circuit

A short, low-pressure circulatory pathway responsible for transporting deoxygenated blood from the heart to the lungs and back, where it picks up oxygen.

Signup and view all the flashcards

Systemic Circuit

A long, high-pressure circulatory pathway responsible for transporting oxygenated blood from the heart to all other body tissues and back.

Signup and view all the flashcards

Study Notes

Blood Composition and Function

  • Blood is a complex fluid comprising plasma and formed elements (red blood cells, white blood cells, and platelets).
  • Erythrocytes (red blood cells) are responsible for oxygen transport. Their structure, function, and life cycle are crucial to understand.
  • Hemostasis is the process of stopping bleeding, involving several steps, and platelets play a critical role.

Clot Retraction and Fibrinolysis

  • Clot retraction is the process of consolidating the formed blood clot.
  • Fibrinolysis is the breakdown of the clot when no longer needed, and the key enzyme plasmin plays a vital role in this process.

Blood Types and Transfusion Reactions

  • Blood groups (e.g., ABO, Rh) are categorized based on antigens on red blood cells.
  • Mismatched blood transfusions can trigger severe reactions (agglutination and hemolysis).
  • The body compensates for blood loss via vasoconstriction and increased erythropoiesis.

Factors Limiting Clot Growth/Formation

  • Homeostatic mechanisms control clot size (removing factors and inhibiting activated clotting factors)
  • Blood flow carries away procoagulants
  • Thrombin is adsorbed onto fibrin threads (limiting clot size)
  • Antithrombin III, protein C inactivate clotting factors

Thromboembolic Conditions

  • Thrombus: a blood clot inside a blood vessel.
  • Embolization happens when a thrombus breaks off.
  • Thrombi can block blood flow to tissues.
  • Treatment options include drugs like tPA to dissolve clots.

Bleeding Disorders

  • Thrombocytopenia: low platelet count, causing easy bruising and internal hemorrhage.
  • Impaired liver function affects procoagulants production and bile production needed for vitamin K absorption.
  • Hemophilia: hereditary bleeding disorders due to intrinsic pathway factor deficiencies (A – factor VIII, B – factor IX).

Transfusion Reactions: Agglutination & Hemolysis

  • Transfusion reactions are potentially fatal if incompatible blood types are mixed.
  • Agglutination occurs when antibodies react with foreign antigens, clumping blood cells.
  • Hemolysis breaks down blood cells, releasing hemoglobin and causing further complications.
  • Autologous transfusions use self-blood to help prevent complications

Blood Typing

  • Blood typing involves using antibodies (like anti-A and anti-B) to determine blood group.
  • Similar techniques can be used to determine Rh factor.
  • Blood type testing is crucial for safe blood transfusions.

The Heart: Anatomy and Physiology

  • The heart is a muscular pump, enclosed in the mediastinum.
  • Layers: pericardium, myocardium, endocardium

Heart Layers

  • Fibrous pericardium protects the heart and prevents overfilling.
  • Serous pericardium is made up of parietal and visceral layers.

Myocardium

  • Muscular tissue of the heart.
  • Fibrous connective tissue reinforces myocardium bundles for support.

Endocardium

  • Innermost lining of the heart chambers.
  • Continuous with the endothelium of blood vessels.

Heart Chambers and Septa

  • The heart has two atria and two ventricles.
  • Interatrial and interventricular septa divide the heart.
  • Coronary sulcus divides the atria and ventricles.
  • Anterior and Posterior intraventricular provide boundary between the ventricles.

Receiving Chambers (Atria)

  • The atria receive blood returning to the heart.
  • Blood enters the right atrium via the superior and inferior vena cava and coronary sinus.
  • Blood enters the left atrium via the pulmonary veins.

Discharging Chambers (Ventricles)

  • The ventricles pump blood out of the heart.
  • The right ventricle pumps blood to the lungs.
  • The left ventricle pumps blood to the body.

Heart Valves

  • Heart valves ensure one-way blood flow.
  • Atrioventricular valves (tricuspid and mitral) control blood flow from atria to ventricles.
  • Semilunar valves (pulmonary and aortic) control blood flow from ventricles to arteries.
  • Valves: Ensure efficient, controlled blood flow.

Pulmonary and Systemic Circulation

  • Pulmonary circuit: blood flow from the heart to the lungs for oxygenation.
  • Systemic circuit: blood flow from the heart to the body to deliver oxygen.
  • The heart's two ventricles pump equal volumes, but the left ventricle must overcome higher pressure for systemic circulation.

Coronary Circulation

  • The coronary circulation supplies oxygen and nutrients to the heart muscle.
  • Coronary arteries and veins supply and drain the heart muscle.
  • Coronary occlusion can lead to angina and myocardial infarction.
  • Anastomoses provide alternate routes for blood flow.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Blood Composition and Function Quiz
27 questions
Blood Composition and Functions
51 questions
Blood and Urine Composition Quiz
4 questions
Blood Composition and Immunity
16 questions
Use Quizgecko on...
Browser
Browser