Podcast
Questions and Answers
What do basophils specifically release in response to allergic reactions?
What do basophils specifically release in response to allergic reactions?
- Heparin and histamine (correct)
- Lysosomal enzymes
- Collagenase and neutrophil factors
- Major basic protein
Which cell type has a bilobed nucleus shaped like an 'S'?
Which cell type has a bilobed nucleus shaped like an 'S'?
- Lymphocyte
- Neutrophil
- Basophil
- Eosinophil (correct)
What is the primary function of neutrophils?
What is the primary function of neutrophils?
- First line of defense against invading microorganisms (correct)
- Activated during parasitic infection
- Regulating allergic reactions
- Releasing histamine
During granulopoiesis, which stage is marked by the last opportunity for cell division?
During granulopoiesis, which stage is marked by the last opportunity for cell division?
What is the function of the azurophilic granules in basophils?
What is the function of the azurophilic granules in basophils?
What percentage of the blood is typically composed of band cells?
What percentage of the blood is typically composed of band cells?
Which type of granule is most abundant in metamyelocytes?
Which type of granule is most abundant in metamyelocytes?
Which feature is characteristic of monocytes?
Which feature is characteristic of monocytes?
Which of the following is NOT a function of monocytes?
Which of the following is NOT a function of monocytes?
In what condition are basophils typically involved?
In what condition are basophils typically involved?
What is the last stage capable of division during monopoiesis?
What is the last stage capable of division during monopoiesis?
What change occurs in the cytoplasmic staining affinity during maturation of neutrophils and eosinophils?
What change occurs in the cytoplasmic staining affinity during maturation of neutrophils and eosinophils?
What type of cells result from monocytes differentiating in various tissues?
What type of cells result from monocytes differentiating in various tissues?
What is the main reason lymphocytes are so crucial to the lymphoid organs?
What is the main reason lymphocytes are so crucial to the lymphoid organs?
Which of the following describes the shape and size of lymphocytes?
Which of the following describes the shape and size of lymphocytes?
Which cell type is known to fuse with others to form multinucleated giant cells during chronic infections?
Which cell type is known to fuse with others to form multinucleated giant cells during chronic infections?
Which cells are primarily involved in antigen presentation within the spleen?
Which cells are primarily involved in antigen presentation within the spleen?
What is the primary location for blood-borne antigens to access within the spleen?
What is the primary location for blood-borne antigens to access within the spleen?
Which component of the spleen contains plasma cells?
Which component of the spleen contains plasma cells?
What distinguishes the stroma of the lymph node from that of the spleen?
What distinguishes the stroma of the lymph node from that of the spleen?
What type of lymphocyte is primarily located in the outer cortex of the lymph node?
What type of lymphocyte is primarily located in the outer cortex of the lymph node?
Which of the following is NOT a component of the spleen's structure?
Which of the following is NOT a component of the spleen's structure?
Which area of the thymus is involved in the differentiation of T lymphocytes?
Which area of the thymus is involved in the differentiation of T lymphocytes?
What feature of the spleen enables the entry of circulating T & B lymphocytes into its parenchyma?
What feature of the spleen enables the entry of circulating T & B lymphocytes into its parenchyma?
What type of epithelium covers the anterior and medial surfaces of the palatine tonsils?
What type of epithelium covers the anterior and medial surfaces of the palatine tonsils?
Which type of tonsil is located at the back of the tongue?
Which type of tonsil is located at the back of the tongue?
What structures are present in the pharyngeal tonsil?
What structures are present in the pharyngeal tonsil?
Which tonsils have no crypts and are covered with folded epithelium?
Which tonsils have no crypts and are covered with folded epithelium?
What type of connective tissue structure separates the lateral and posterior surfaces of the palatine tonsils from adjacent organs?
What type of connective tissue structure separates the lateral and posterior surfaces of the palatine tonsils from adjacent organs?
What is a characteristic feature of tubal tonsils in terms of epithelium?
What is a characteristic feature of tubal tonsils in terms of epithelium?
What immune cells are present among the loose lymphoid tissue in the palatine tonsils?
What immune cells are present among the loose lymphoid tissue in the palatine tonsils?
Which of the following is true about the lymph vessels present in the tonsils?
Which of the following is true about the lymph vessels present in the tonsils?
What is the primary function of plasma cells?
What is the primary function of plasma cells?
Which cells respond more rapidly upon subsequent exposure to the same antigen?
Which cells respond more rapidly upon subsequent exposure to the same antigen?
Which organ is primarily responsible for the maturation of T lymphocytes?
Which organ is primarily responsible for the maturation of T lymphocytes?
What type of lymphoid tissue primarily reacts with foreign antigens to elicit an immune response?
What type of lymphoid tissue primarily reacts with foreign antigens to elicit an immune response?
What is a characteristic cell found in the thymic cortex?
What is a characteristic cell found in the thymic cortex?
Which lymphoid organ is known to progressively atrophy at puberty?
Which lymphoid organ is known to progressively atrophy at puberty?
Which cell type is involved in phagocytosing and presenting foreign antigens to T lymphocytes?
Which cell type is involved in phagocytosing and presenting foreign antigens to T lymphocytes?
What type of cells do natural killer cells originate from?
What type of cells do natural killer cells originate from?
What type of epithelium is found in palatine tonsils?
What type of epithelium is found in palatine tonsils?
Where are the lingual tonsils located?
Where are the lingual tonsils located?
What is the normal range for white blood cell (WBC) count in blood?
What is the normal range for white blood cell (WBC) count in blood?
What characterizes microcytosis in red blood cells (RBCs)?
What characterizes microcytosis in red blood cells (RBCs)?
Which tonsil is characterized by having a single crypt?
Which tonsil is characterized by having a single crypt?
What is a common shape abnormality of red blood cells known as crenation?
What is a common shape abnormality of red blood cells known as crenation?
Which type of tonsil surrounds the opening of the Eustachian tube?
Which type of tonsil surrounds the opening of the Eustachian tube?
What does polycythemia indicate regarding red blood cell count?
What does polycythemia indicate regarding red blood cell count?
Flashcards
What are specific granules of a basophil?
What are specific granules of a basophil?
Containing histamine and heparin, these granules are important for the basophil's role in allergic reactions.
What are the azurophilic granules of a basophil?
What are the azurophilic granules of a basophil?
Containing lysosomal enzymes, these smaller granules help the basophil break down cellular debris.
What is the main function of basophils?
What is the main function of basophils?
Basophils are responsible for releasing histamine and heparin during allergic reactions, contributing to inflammation and blood vessel dilation.
What is the function of neutrophils?
What is the function of neutrophils?
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What is the function of eosinophils?
What is the function of eosinophils?
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What is a promyelocyte?
What is a promyelocyte?
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What is a myelocyte?
What is a myelocyte?
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What is a metamyelocyte?
What is a metamyelocyte?
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What are band cells?
What are band cells?
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How do mature granulocyte nuclei differ from immature ones?
How do mature granulocyte nuclei differ from immature ones?
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Why are monocytes called 'monocytes'?
Why are monocytes called 'monocytes'?
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What are the key features of a monocyte under a light microscope?
What are the key features of a monocyte under a light microscope?
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How does a monocyte's shape help with its function?
How does a monocyte's shape help with its function?
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What do azurophilic granules within monocytes contain?
What do azurophilic granules within monocytes contain?
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What is the mononuclear phagocytic system?
What is the mononuclear phagocytic system?
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How are monocytes related to the immune response?
How are monocytes related to the immune response?
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What are NK cells?
What are NK cells?
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What is the thymus?
What is the thymus?
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What are epithelial reticular cells?
What are epithelial reticular cells?
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What is the thymic cortex?
What is the thymic cortex?
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What is the thymic medulla?
What is the thymic medulla?
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What are primary lymphoid organs?
What are primary lymphoid organs?
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What are secondary lymphoid organs?
What are secondary lymphoid organs?
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What is the spleen?
What is the spleen?
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What is the marginal zone of the spleen?
What is the marginal zone of the spleen?
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What is the function of the marginal sinuses in the spleen?
What is the function of the marginal sinuses in the spleen?
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What is the periarterial lymphoid sheath (PALS)?
What is the periarterial lymphoid sheath (PALS)?
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What is a lymphatic nodule in the spleen?
What is a lymphatic nodule in the spleen?
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What is the red pulp of the spleen?
What is the red pulp of the spleen?
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What are splenic cords?
What are splenic cords?
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What are blood sinuses in the spleen?
What are blood sinuses in the spleen?
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What are interdigitating dendritic cells?
What are interdigitating dendritic cells?
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What are the palatine tonsils?
What are the palatine tonsils?
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What are the lingual tonsils?
What are the lingual tonsils?
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What is the pharyngeal tonsil?
What is the pharyngeal tonsil?
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What are the tubal tonsils?
What are the tubal tonsils?
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What are tonsil crypts?
What are tonsil crypts?
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What are lingual tonsil crypts?
What are lingual tonsil crypts?
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What is pseudostratified columnar ciliated epithelium?
What is pseudostratified columnar ciliated epithelium?
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What is non-keratinized stratified squamous epithelium?
What is non-keratinized stratified squamous epithelium?
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Waldeyer's Ring
Waldeyer's Ring
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Palatine Tonsils
Palatine Tonsils
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Lingual Tonsil
Lingual Tonsil
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Pharyngeal Tonsil (Adenoids)
Pharyngeal Tonsil (Adenoids)
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Tubal Tonsils
Tubal Tonsils
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Polycythemia
Polycythemia
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Anemia
Anemia
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Microcytosis
Microcytosis
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Study Notes
Blood
- Blood is a specialized connective tissue composed of plasma and formed elements
- Plasma forms the matrix
- Formed elements are the cells, with no fibers present
Formed Elements:
-
Red Blood Corpuscles (RBCs):
- Average count: Males 5-5.5 million/mm³; Females 4.5-5 million/mm³
- Life span: 100-120 days
- Old or damaged RBCs are phagocytosed by macrophages in the spleen and liver
- Function: contain hemoglobin for gas exchange
-
White Blood Cells (WBCs) or Leukocytes:
- Granular Leukocytes: neutrophils, eosinophils, basophils
- Agranular Leukocytes: lymphocytes, monocytes
-
Platelets:
- Normal count: 150,000-400,000/mm³
- Function: blood clotting in response to vascular injury
Blood Smear Preparation:
- Giemsa's stain differentiates cells by their nuclei and cytoplasmic granules (basophilic, eosinophilic, azurophilic)
Blood Count:
- The average number of formed blood elements per cubic millimeter of blood, including RBCs count, total leukocytic count, platelet count, and differential leukocytic count (percentage of each WBC type relative to total WBCs).
Erythropoiesis:
- The process of RBC formation
- Takes approximately 7 days
- Stages include: proerythroblasts, basophilic erythroblasts, polychromatophilic erythroblasts, orthochromatophilic erythroblasts (normoblasts), reticulocytes, and mature RBCs
Granulopoiesis:
- The process of granulocyte formation
- Stages include: promyelocytes, myelocytes (neutrophil, eosinophil, basophil), metamyelocytes, band cells, and mature granulocytes
Monopoiesis:
- The process of monocyte formation
- Stages include: promonocytes and monocytes
Lymphopoiesis:
- The process of lymphocyte formation
- Different types of lymphocytes are formed: T and B lymphocytes, which differentiate in the thymus and bone marrow, respectively
Lymphoid Organs:
- Thymus:
- Primary lymphoid organ
- Site for T lymphocyte maturation
- Lymph Nodes:
- Secondary lymphoid organ
- Site for filtering lymph
- Spleen:
- Largest lymphoid organ
- Site for blood filtration, immune responses, and RBC destruction:
- White pulp: containing lymphoid nodules with T and B Cells.
- Red pulp: containing blood sinuses and splenic cords (specialized connective tissue housing macrophages and RBCs)
Tonsils:
- Partially encapsulated lymphoid tissues located in the oropharynx, nasopharynx, and in the lingual and tubal regions of the mouth
Abnormalities of Blood Elements:
- Various abnormalities can affect RBCs, platelets, and WBCs counts and types, broadly categorized as increased or decreased counts and abnormal morphology.
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