Blood Cells and Their Functions

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Questions and Answers

What do basophils specifically release in response to allergic reactions?

  • Heparin and histamine (correct)
  • Lysosomal enzymes
  • Collagenase and neutrophil factors
  • Major basic protein

Which cell type has a bilobed nucleus shaped like an 'S'?

  • Lymphocyte
  • Neutrophil
  • Basophil
  • Eosinophil (correct)

What is the primary function of neutrophils?

  • First line of defense against invading microorganisms (correct)
  • Activated during parasitic infection
  • Regulating allergic reactions
  • Releasing histamine

During granulopoiesis, which stage is marked by the last opportunity for cell division?

<p>Myelocytes (D)</p> Signup and view all the answers

What is the function of the azurophilic granules in basophils?

<p>Store lysosomal enzymes (C)</p> Signup and view all the answers

What percentage of the blood is typically composed of band cells?

<p>0-3% (C)</p> Signup and view all the answers

Which type of granule is most abundant in metamyelocytes?

<p>Specific granules (D)</p> Signup and view all the answers

Which feature is characteristic of monocytes?

<p>Single, non-segmented nucleus (C)</p> Signup and view all the answers

Which of the following is NOT a function of monocytes?

<p>Rapidly produce antibodies (D)</p> Signup and view all the answers

In what condition are basophils typically involved?

<p>Hypersensitivity reactions (B)</p> Signup and view all the answers

What is the last stage capable of division during monopoiesis?

<p>Promonocyte (A)</p> Signup and view all the answers

What change occurs in the cytoplasmic staining affinity during maturation of neutrophils and eosinophils?

<p>Decreased basophilia and increased eosinophilia (D)</p> Signup and view all the answers

What type of cells result from monocytes differentiating in various tissues?

<p>Specific tissue phagocytic cells (A)</p> Signup and view all the answers

What is the main reason lymphocytes are so crucial to the lymphoid organs?

<p>They are the main cell population. (A)</p> Signup and view all the answers

Which of the following describes the shape and size of lymphocytes?

<p>Rounded cells with variable diameter (A)</p> Signup and view all the answers

Which cell type is known to fuse with others to form multinucleated giant cells during chronic infections?

<p>Monocytes (A)</p> Signup and view all the answers

Which cells are primarily involved in antigen presentation within the spleen?

<p>Interdigitating dendritic cells (D)</p> Signup and view all the answers

What is the primary location for blood-borne antigens to access within the spleen?

<p>White pulp (A)</p> Signup and view all the answers

Which component of the spleen contains plasma cells?

<p>Red pulp (B)</p> Signup and view all the answers

What distinguishes the stroma of the lymph node from that of the spleen?

<p>Presence of reticular fibers (C)</p> Signup and view all the answers

What type of lymphocyte is primarily located in the outer cortex of the lymph node?

<p>B lymphocytes (B)</p> Signup and view all the answers

Which of the following is NOT a component of the spleen's structure?

<p>Thymic corpuscles (D)</p> Signup and view all the answers

Which area of the thymus is involved in the differentiation of T lymphocytes?

<p>Cortex (D)</p> Signup and view all the answers

What feature of the spleen enables the entry of circulating T & B lymphocytes into its parenchyma?

<p>Marginal sinuses (D)</p> Signup and view all the answers

What type of epithelium covers the anterior and medial surfaces of the palatine tonsils?

<p>Non-keratinized stratified squamous epithelium (D)</p> Signup and view all the answers

Which type of tonsil is located at the back of the tongue?

<p>Lingual tonsils (B)</p> Signup and view all the answers

What structures are present in the pharyngeal tonsil?

<p>Lymphoid nodules and pseudostratified columnar ciliated epithelium (D)</p> Signup and view all the answers

Which tonsils have no crypts and are covered with folded epithelium?

<p>Pharyngeal tonsils (C)</p> Signup and view all the answers

What type of connective tissue structure separates the lateral and posterior surfaces of the palatine tonsils from adjacent organs?

<p>Fibrous capsule (A)</p> Signup and view all the answers

What is a characteristic feature of tubal tonsils in terms of epithelium?

<p>Pseudostratified columnar ciliated epithelium with few crypts (B)</p> Signup and view all the answers

What immune cells are present among the loose lymphoid tissue in the palatine tonsils?

<p>Macrophages and lymphocytes (B)</p> Signup and view all the answers

Which of the following is true about the lymph vessels present in the tonsils?

<p>No afferent lymph vessels are present (C)</p> Signup and view all the answers

What is the primary function of plasma cells?

<p>Secrete antibodies (D)</p> Signup and view all the answers

Which cells respond more rapidly upon subsequent exposure to the same antigen?

<p>Memory B cells (A)</p> Signup and view all the answers

Which organ is primarily responsible for the maturation of T lymphocytes?

<p>Thymus (B)</p> Signup and view all the answers

What type of lymphoid tissue primarily reacts with foreign antigens to elicit an immune response?

<p>Secondary lymphoid tissues (B)</p> Signup and view all the answers

What is a characteristic cell found in the thymic cortex?

<p>Thymocytes (B)</p> Signup and view all the answers

Which lymphoid organ is known to progressively atrophy at puberty?

<p>Thymus (D)</p> Signup and view all the answers

Which cell type is involved in phagocytosing and presenting foreign antigens to T lymphocytes?

<p>Macrophages (B)</p> Signup and view all the answers

What type of cells do natural killer cells originate from?

<p>Bone marrow precursors of T and B cells (D)</p> Signup and view all the answers

What type of epithelium is found in palatine tonsils?

<p>Stratified squamous epithelium (B)</p> Signup and view all the answers

Where are the lingual tonsils located?

<p>On the dorsal surface of the posterior third of the tongue (C)</p> Signup and view all the answers

What is the normal range for white blood cell (WBC) count in blood?

<p>4000-10,000 / mm blood (C)</p> Signup and view all the answers

What characterizes microcytosis in red blood cells (RBCs)?

<p>RBC diameter is less than 6 microns (C)</p> Signup and view all the answers

Which tonsil is characterized by having a single crypt?

<p>Pharyngeal tonsil (A)</p> Signup and view all the answers

What is a common shape abnormality of red blood cells known as crenation?

<p>RBCs shrink and develop spiny protrusions (A)</p> Signup and view all the answers

Which type of tonsil surrounds the opening of the Eustachian tube?

<p>Tubal tonsil (D)</p> Signup and view all the answers

What does polycythemia indicate regarding red blood cell count?

<p>Increase in RBCs number (C)</p> Signup and view all the answers

Flashcards

What are specific granules of a basophil?

Containing histamine and heparin, these granules are important for the basophil's role in allergic reactions.

What are the azurophilic granules of a basophil?

Containing lysosomal enzymes, these smaller granules help the basophil break down cellular debris.

What is the main function of basophils?

Basophils are responsible for releasing histamine and heparin during allergic reactions, contributing to inflammation and blood vessel dilation.

What is the function of neutrophils?

These are the first responders to infection, engulfing and destroying invading microorganisms.

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What is the function of eosinophils?

These cells play a crucial role in fighting parasites and regulating allergic reactions.

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What is a promyelocyte?

Promyelocytes are immature cells that produce azurophilic granules, marking the beginning of granulocyte development.

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What is a myelocyte?

Myelocytes begin producing specific granules alongside azurophilic granules, defining the type of granulocyte.

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What is a metamyelocyte?

Metamyelocytes are characterized by an abundance of specific granules, reflecting the cell's nearly mature form.

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What are band cells?

Immature neutrophils with a band-shaped nucleus, typically representing 0-3% of blood cells. Their percentage increases during acute infections.

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How do mature granulocyte nuclei differ from immature ones?

Mature granulocytes have a segmented nucleus, unique to each type of granulocyte.

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Why are monocytes called 'monocytes'?

Monocytes are named for their single, non-segmented nucleus. They make up 3-8% of leukocytes.

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What are the key features of a monocyte under a light microscope?

Monocytes are the largest leukocytes and have a large, eccentric, kidney-shaped or horseshoe-shaped nucleus. Their cytoplasm is abundant, pale basophilic, and finely granular.

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How does a monocyte's shape help with its function?

Monocytes have an irregular outline due to extensions called pseudopodia. These extensions aid in their motility and phagocytosis.

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What do azurophilic granules within monocytes contain?

Monocytes contain small, dense granules called azurophilic granules, which contain lysosomal hydrolytic enzymes. These enzymes help break down engulfed material.

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What is the mononuclear phagocytic system?

Monocytes circulate in the blood and then migrate to tissues, differentiating into specific phagocytic cells that form the mononuclear phagocytic system.

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How are monocytes related to the immune response?

Monocytes can process and present antigens to T lymphocytes, making them important for the immune response.

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What are NK cells?

These cells differentiate from the same precursors as T and B cells, but lack their surface markers. They play a crucial role in killing virally infected cells and malignant cells, thus contributing to the body's defense against infections and cancer.

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What is the thymus?

Located in the superior mediastinum, it is a primary lymphoid organ responsible for T cell development and maturation, mainly during childhood. Its activity declines with age, replaced by adipose tissue.

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What are epithelial reticular cells?

These cells support the developing T lymphocytes within the thymus, forming a network called the cytoreticulum. They provide essential structural support and contribute to T cell maturation.

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What is the thymic cortex?

This region of the thymus is densely packed with developing T lymphocytes, epithelial reticular cells, and macrophages, giving it a dark appearance.

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What is the thymic medulla?

This region of the thymus is lighter in color due to the presence of Hassall's corpuscles, which are clusters of epithelial reticular cells. Mature T cells are found in this area.

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What are primary lymphoid organs?

These are the sites where lymphocytes undergo development and maturation, preparing them to perform their immune functions.

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What are secondary lymphoid organs?

These are the sites where lymphocytes encounter antigens and mount an immune response.

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What is the spleen?

This structure, found in the abdomen, is a secondary lymphoid organ responsible for filtering blood and removing old or damaged red blood cells. It also houses lymphocytes that mount immune responses against blood-borne antigens.

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What is the marginal zone of the spleen?

The region of the spleen where circulating T and B lymphocytes enter to find their specific location.

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What is the function of the marginal sinuses in the spleen?

The first point of contact for blood-borne antigens entering the spleen's tissue.

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What is the periarterial lymphoid sheath (PALS)?

A region within the white pulp of the spleen containing a central artery surrounded by a sheath of lymphocytes.

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What is a lymphatic nodule in the spleen?

A collection of B lymphocytes in the white pulp of the spleen, forming a spherical structure.

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What is the red pulp of the spleen?

The part of the spleen responsible for filtering blood and removing old or damaged red blood cells.

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What are splenic cords?

These are the structural components of the red pulp composed of reticular cells and fibers.

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What are blood sinuses in the spleen?

These are blood-filled spaces within the red pulp where blood cells flow and are filtered.

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What are interdigitating dendritic cells?

They are specialized antigen-presenting cells found in the white pulp of the spleen. They help initiate immune responses by presenting antigens to T lymphocytes.

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What are the palatine tonsils?

A ring of lymphoid tissue located at the back of the mouth, within the oropharynx, protecting against inhaled and ingested pathogens.

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What are the lingual tonsils?

Found on the back of the tongue, these tonsils also play a role in immune defense.

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What is the pharyngeal tonsil?

A single tonsil found in the nasopharynx, the uppermost part of the throat, it protects the respiratory tract from infection.

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What are the tubal tonsils?

Located near the opening of the Eustachian tube connects the middle ear to the back of the throat. They help prevent ear infections.

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What are tonsil crypts?

These are invaginations on the surface of the palatine tonsils, allowing for the trapping and presentation of pathogens to immune cells.

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What are lingual tonsil crypts?

Similar to the crypts on the palatine tonsils, these pockets on the lingual tonsils also help trap pathogens.

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What is pseudostratified columnar ciliated epithelium?

This type of epithelium lines the pharyngeal tonsil, characterized by its numerous cilia that help move mucus and trapped pathogens.

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What is non-keratinized stratified squamous epithelium?

This type of epithelium lines the palatine tonsils, forming a tough, protective barrier over the tonsil surface.

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Waldeyer's Ring

A ring of lymphatic tissue located in the pharynx, consisting of tonsils that protect against infection.

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Palatine Tonsils

The two tonsils located on the lateral walls of the oropharynx.

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Lingual Tonsil

The single tonsil found on the posterior surface of the tongue.

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Pharyngeal Tonsil (Adenoids)

The single tonsil located in the posterosuperior portion of the pharynx (nasopharynx).

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Tubal Tonsils

Two small tonsils located around the opening of the Eustachian tube in the lateral wall of the nasopharynx.

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Polycythemia

An abnormal increase in the number of red blood cells (RBCs) in the blood.

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Anemia

A deficiency in the number of red blood cells (RBCs) in the blood.

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Microcytosis

A condition where red blood cells (RBCs) are abnormally small.

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Study Notes

Blood

  • Blood is a specialized connective tissue composed of plasma and formed elements
  • Plasma forms the matrix
  • Formed elements are the cells, with no fibers present

Formed Elements:

  • Red Blood Corpuscles (RBCs):

    • Average count: Males 5-5.5 million/mm³; Females 4.5-5 million/mm³
    • Life span: 100-120 days
    • Old or damaged RBCs are phagocytosed by macrophages in the spleen and liver
    • Function: contain hemoglobin for gas exchange
  • White Blood Cells (WBCs) or Leukocytes:

    • Granular Leukocytes: neutrophils, eosinophils, basophils
    • Agranular Leukocytes: lymphocytes, monocytes
  • Platelets:

    • Normal count: 150,000-400,000/mm³
    • Function: blood clotting in response to vascular injury

Blood Smear Preparation:

  • Giemsa's stain differentiates cells by their nuclei and cytoplasmic granules (basophilic, eosinophilic, azurophilic)

Blood Count:

  • The average number of formed blood elements per cubic millimeter of blood, including RBCs count, total leukocytic count, platelet count, and differential leukocytic count (percentage of each WBC type relative to total WBCs).

Erythropoiesis:

  • The process of RBC formation
  • Takes approximately 7 days
  • Stages include: proerythroblasts, basophilic erythroblasts, polychromatophilic erythroblasts, orthochromatophilic erythroblasts (normoblasts), reticulocytes, and mature RBCs

Granulopoiesis:

  • The process of granulocyte formation
  • Stages include: promyelocytes, myelocytes (neutrophil, eosinophil, basophil), metamyelocytes, band cells, and mature granulocytes

Monopoiesis:

  • The process of monocyte formation
  • Stages include: promonocytes and monocytes

Lymphopoiesis:

  • The process of lymphocyte formation
  • Different types of lymphocytes are formed: T and B lymphocytes, which differentiate in the thymus and bone marrow, respectively

Lymphoid Organs:

  • Thymus:
    • Primary lymphoid organ
    • Site for T lymphocyte maturation
  • Lymph Nodes:
    • Secondary lymphoid organ
    • Site for filtering lymph
  • Spleen:
    • Largest lymphoid organ
    • Site for blood filtration, immune responses, and RBC destruction:
    • White pulp: containing lymphoid nodules with T and B Cells.
    • Red pulp: containing blood sinuses and splenic cords (specialized connective tissue housing macrophages and RBCs)

Tonsils:

  • Partially encapsulated lymphoid tissues located in the oropharynx, nasopharynx, and in the lingual and tubal regions of the mouth

Abnormalities of Blood Elements:

  • Various abnormalities can affect RBCs, platelets, and WBCs counts and types, broadly categorized as increased or decreased counts and abnormal morphology.

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