Podcast
Questions and Answers
What is the main function of the blood-brain barrier (BBB)?
What is the main function of the blood-brain barrier (BBB)?
- To protect the brain from undesired blood circulating agents (correct)
- To support the astrocytic end feet
- To collaborate with pericytes
- To regulate autocrine and paracrine stimulations
What is the purpose of utilizing smart pharmaceuticals engineered as seamless nanosystems?
What is the purpose of utilizing smart pharmaceuticals engineered as seamless nanosystems?
- To collaborate with pericytes for drug delivery
- To regulate autocrine and paracrine stimulations
- To provide simultaneous imaging and therapy (correct)
- To make BBB impermeable to many compounds
What is the role of pericyte and astrocyte cells in relation to the BBB?
What is the role of pericyte and astrocyte cells in relation to the BBB?
- To make BBB impermeable to many compounds
- To regulate autocrine and paracrine stimulations
- To support BCECs physically and by sharing the capillary basement membrane with the endothelium (correct)
- To provide selective barrier functionalities
Why is it important to fully understand the biofunctions of BBB?
Why is it important to fully understand the biofunctions of BBB?
What is the conclusion drawn regarding the need for advanced smart multifunctional nanomedicines?
What is the conclusion drawn regarding the need for advanced smart multifunctional nanomedicines?
What is responsible for the selective control of transportation process through the blood-brain barrier?
What is responsible for the selective control of transportation process through the blood-brain barrier?
What is the main challenge in brain drug delivery and targeting?
What is the main challenge in brain drug delivery and targeting?
What is the role of brain capillary endothelial cells (BCECs) in brain drug delivery?
What is the role of brain capillary endothelial cells (BCECs) in brain drug delivery?
What makes brain drug delivery and targeting very challenging?
What makes brain drug delivery and targeting very challenging?
How do brain capillary endothelial cells (BCECs) contribute to brain drug delivery?
How do brain capillary endothelial cells (BCECs) contribute to brain drug delivery?
Astrocyte cells have a major role in the physical barrier function of BBB
Astrocyte cells have a major role in the physical barrier function of BBB
The permeability of BBB is regulated by intricate transport machineries located at the membrane of the BCECs
The permeability of BBB is regulated by intricate transport machineries located at the membrane of the BCECs
BBB protects the brain from undesired blood circulating agents
BBB protects the brain from undesired blood circulating agents
The article suggests that fully understanding the biofunctions of BBB is not essential for engineering intelligent seamless therapeutics
The article suggests that fully understanding the biofunctions of BBB is not essential for engineering intelligent seamless therapeutics
Advanced smart multifunctional nanomedicines are needed for effective brain drug delivery and targeting
Advanced smart multifunctional nanomedicines are needed for effective brain drug delivery and targeting
The entry of blood circulating agents into the brain is not highly selectively controlled by specific transport machineries at the blood-brain barrier (BBB)
The entry of blood circulating agents into the brain is not highly selectively controlled by specific transport machineries at the blood-brain barrier (BBB)
Brain capillary endothelial cells (BCECs form unique biological structure and architecture in association with astrocytes and pericytes.
Brain capillary endothelial cells (BCECs form unique biological structure and architecture in association with astrocytes and pericytes.
Brain drug delivery and targeting are not very challenging due to the excellent barrier restrictiveness of the blood-brain barrier (BBB)
Brain drug delivery and targeting are not very challenging due to the excellent barrier restrictiveness of the blood-brain barrier (BBB)
The brain capillary endothelial cells (BCECs) selectively control the transportation process through carrier and/or receptor mediated transport machineries
The brain capillary endothelial cells (BCECs) selectively control the transportation process through carrier and/or receptor mediated transport machineries
The blood-brain barrier (BBB) does not block the paracellular inward/outward traverse of biomolecules/compounds
The blood-brain barrier (BBB) does not block the paracellular inward/outward traverse of biomolecules/compounds
