Blood-Brain Barrier and Drug Delivery
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Questions and Answers

What is the main function of the blood-brain barrier (BBB)?

  • To protect the brain from undesired blood circulating agents (correct)
  • To support the astrocytic end feet
  • To collaborate with pericytes
  • To regulate autocrine and paracrine stimulations

    • What is the purpose of utilizing smart pharmaceuticals engineered as seamless nanosystems?

  • To collaborate with pericytes for drug delivery
  • To regulate autocrine and paracrine stimulations
  • To provide simultaneous imaging and therapy (correct)
  • To make BBB impermeable to many compounds

    • What is the role of pericyte and astrocyte cells in relation to the BBB?

  • To make BBB impermeable to many compounds
  • To regulate autocrine and paracrine stimulations
  • To support BCECs physically and by sharing the capillary basement membrane with the endothelium (correct)
  • To provide selective barrier functionalities

    • Why is it important to fully understand the biofunctions of BBB?

    <p>To selectively control inward and outward transportation mechanisms</p> Signup and view all the answers

    What is the conclusion drawn regarding the need for advanced smart multifunctional nanomedicines?

    <p>They are needed for effective brain drug delivery and targeting</p> Signup and view all the answers

    What is responsible for the selective control of transportation process through the blood-brain barrier?

    <p>Carrier and/or receptor mediated transport machineries</p> Signup and view all the answers

    What is the main challenge in brain drug delivery and targeting?

    <p>The high selectivity of the blood-brain barrier</p> Signup and view all the answers

    What is the role of brain capillary endothelial cells (BCECs) in brain drug delivery?

    <p>They express restrictive tight junctional complexes</p> Signup and view all the answers

    What makes brain drug delivery and targeting very challenging?

    <p>Unrestricted inward/outward traverse of biomolecules/compounds</p> Signup and view all the answers

    How do brain capillary endothelial cells (BCECs) contribute to brain drug delivery?

    <p>They form unique biological structure and architecture</p> Signup and view all the answers

    Astrocyte cells have a major role in the physical barrier function of BBB

    <p>False</p> Signup and view all the answers

    The permeability of BBB is regulated by intricate transport machineries located at the membrane of the BCECs

    <p>True</p> Signup and view all the answers

    BBB protects the brain from undesired blood circulating agents

    <p>True</p> Signup and view all the answers

    The article suggests that fully understanding the biofunctions of BBB is not essential for engineering intelligent seamless therapeutics

    <p>False</p> Signup and view all the answers

    Advanced smart multifunctional nanomedicines are needed for effective brain drug delivery and targeting

    <p>True</p> Signup and view all the answers

    The entry of blood circulating agents into the brain is not highly selectively controlled by specific transport machineries at the blood-brain barrier (BBB)

    <p>False</p> Signup and view all the answers

    Brain capillary endothelial cells (BCECs form unique biological structure and architecture in association with astrocytes and pericytes.

    <p>True</p> Signup and view all the answers

    Brain drug delivery and targeting are not very challenging due to the excellent barrier restrictiveness of the blood-brain barrier (BBB)

    <p>False</p> Signup and view all the answers

    The brain capillary endothelial cells (BCECs) selectively control the transportation process through carrier and/or receptor mediated transport machineries

    <p>True</p> Signup and view all the answers

    The blood-brain barrier (BBB) does not block the paracellular inward/outward traverse of biomolecules/compounds

    <p>False</p> Signup and view all the answers

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