Blood-Brain Barrier and Drug Delivery

What is the main function of the blood-brain barrier (BBB)?

What is the purpose of utilizing smart pharmaceuticals engineered as seamless nanosystems?

What is the role of pericyte and astrocyte cells in relation to the BBB?

Why is it important to fully understand the biofunctions of BBB?

What is the conclusion drawn regarding the need for advanced smart multifunctional nanomedicines?

What is responsible for the selective control of transportation process through the blood-brain barrier?

What is the main challenge in brain drug delivery and targeting?

What is the role of brain capillary endothelial cells (BCECs) in brain drug delivery?

What makes brain drug delivery and targeting very challenging?

How do brain capillary endothelial cells (BCECs) contribute to brain drug delivery?

Astrocyte cells have a major role in the physical barrier function of BBB

The permeability of BBB is regulated by intricate transport machineries located at the membrane of the BCECs

BBB protects the brain from undesired blood circulating agents

The article suggests that fully understanding the biofunctions of BBB is not essential for engineering intelligent seamless therapeutics

Advanced smart multifunctional nanomedicines are needed for effective brain drug delivery and targeting

The entry of blood circulating agents into the brain is not highly selectively controlled by specific transport machineries at the blood-brain barrier (BBB)

Brain capillary endothelial cells (BCECs form unique biological structure and architecture in association with astrocytes and pericytes.

Brain drug delivery and targeting are not very challenging due to the excellent barrier restrictiveness of the blood-brain barrier (BBB)

The brain capillary endothelial cells (BCECs) selectively control the transportation process through carrier and/or receptor mediated transport machineries

The blood-brain barrier (BBB) does not block the paracellular inward/outward traverse of biomolecules/compounds