Blood and Tissue Flagellates: Leishmania spp. Quiz
39 Questions
4 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Match the Leishmania species with their primary transmission vector:

L.donovani, L.infantum, L.tropica, L.major, L.aethiopica = Phlebotomus sandflies L.mexicana, L.braziliensis = Lutzomyia and Psychodopygus sandflies

Match the stage of Leishmania with its morphology:

Amastigote = Spherical or subspherical Promastigote = Pyriform or spindle shape with flagellum

Match the natural reservoir hosts with Leishmania:

Humans, dogs, wild rodents = Natural reservoir hosts

Match the location in the sandfly with the transformation of amastigotes to promastigotes:

<p>Stomach of the sandfly = Transformation of amastigotes to promastigotes</p> Signup and view all the answers

Match the following symptoms with the type of leishmaniasis:

<p>Enlargement of spleen, liver, and lymph nodes = Visceral leishmaniasis Widespread skin lesions resembling leprosy = Diffuse cutaneous leishmaniasis Raised, red lesion at the bite site = Cutaneous leishmaniasis Measle-like skin lesions on the face = Post kala-azar dermal leishmaniasis</p> Signup and view all the answers

Match the following diagnostic methods with the corresponding test:

<p>Microscopic analysis using Wright or Giemsa stain = Skin scraping Needle aspiration of tissue fluid = Culture in specific media Blood film stained with Leishman or Giemsa stain = Parasitological diagnosis Serological testing = Immunological tests</p> Signup and view all the answers

Match the following terms with their corresponding definitions:

<p>Amastigotes = Replicate in macrophage cells Protozoans = Daughter cells that migrate to fresh cells or bloodstream Reticuloendothelial cells = Habitat of Leishmania parasites Viscerotropic = Initial stage of visceral leishmaniasis</p> Signup and view all the answers

Match the following types of leishmaniasis with their characteristics:

<p>Visceral leishmaniasis = Causes damage primarily to the nose and mouth Cutaneous leishmaniasis = A raised, red lesion develops at the site of the bite Mucocutaneous leishmaniasis (espundia) = Both skin and mucosal ulcers occur New world leishmaniasis = Caused by L.braziliensis and L.mexicana</p> Signup and view all the answers

Match the following treatments with the type of leishmaniasis they are used for:

<p>Liposomal amphotericin B = Visceral disease Paromomycin, fluconazole, or pentamidine = Cutaneous disease A combination of pentavalent antimonials and paromomycin = Visceral disease Miltefosine = Visceral disease</p> Signup and view all the answers

Match the following prevention methods with their description:

<p>Sleeping under nets treated with insecticide = Partly prevents leishmaniasis Spraying insecticides to kill sandflies = Partly prevents leishmaniasis Treating people with the disease early = To prevent further spread Reservoir control programs = Partly prevents leishmaniasis</p> Signup and view all the answers

Match the following diagnostic methods with the type of leishmaniasis they are used for:

<p>Demonstration of amastigote form of L.donovani by a microscope = PKDL Leishman-stained smear prepared from biopsy material obtained from nodular lesions = PKDL Raised, red lesion developing at the site of the bite = Cutaneous leishmaniasis Destructive mucocutaneous lesions appearing elsewhere = Mucocutaneous leishmaniasis</p> Signup and view all the answers

Leishmaniasis is spread by the bite of certain types of mosquitoes.

<p>False</p> Signup and view all the answers

The term 'New World' refers to Europe and Asia.

<p>False</p> Signup and view all the answers

The life cycle of Leishmania is completed in three hosts: humans, sandflies, and dogs.

<p>False</p> Signup and view all the answers

Promastigotes live intracellularly in the alimentary canal of sandflies.

<p>False</p> Signup and view all the answers

In active cases of kala-azar, the Leishmanin test is positive because patients have a strong delayed hypersensitivity response.

<p>False</p> Signup and view all the answers

Mucocutaneous leishmaniasis primarily damages the skin, leading to skin ulcers.

<p>False</p> Signup and view all the answers

Leishmania parasites replicate extracellularly within human macrophages.

<p>False</p> Signup and view all the answers

Cutaneous leishmaniasis lesions may heal without scarring and not reappear elsewhere.

<p>False</p> Signup and view all the answers

Vaccination against leishmaniasis mainly induces a humoral response to control the infection.

<p>False</p> Signup and view all the answers

Prevention of leishmaniasis includes treating reservoir hosts to control the spread of the disease.

<p>True</p> Signup and view all the answers

Amastigotes transform into the larger trypomastigote form inside the cells.

<p>False</p> Signup and view all the answers

Cutaneous leishmaniasis is mainly caused by L.tropica, L.major, and L.aethiopica.

<p>True</p> Signup and view all the answers

Diffuse cutaneous leishmaniasis heals on its own without leaving scars.

<p>False</p> Signup and view all the answers

Leishmania invades human macrophages and replicates extracellularly.

<p>False</p> Signup and view all the answers

Diagnosis of cutaneous leishmaniasis can be done using DNA testing (PCR).

<p>True</p> Signup and view all the answers

Visceral leishmaniasis is also known as white fever.

<p>False</p> Signup and view all the answers

Visceral leishmaniasis affects the liver, spleen, bone marrow, and lymph nodes.

<p>True</p> Signup and view all the answers

Post kala-azar dermal leishmaniasis occurs after successful treatment of visceral leishmaniasis.

<p>True</p> Signup and view all the answers

PKDL is seen with L.infantum infection.

<p>False</p> Signup and view all the answers

Blood count and serum protein estimation are specific diagnostic tests for visceral leishmaniasis.

<p>False</p> Signup and view all the answers

Serological testing is a common diagnostic method used in areas where leishmaniasis is endemic.

<p>True</p> Signup and view all the answers

Leishmania DNA can be detected using PCR tests in diagnosing the disease.

<p>True</p> Signup and view all the answers

Where does the life cycle of T.brucei mostly occur?

<p>In the gut of tsetse flies</p> Signup and view all the answers

Which stage of T.brucei can penetrate the blood vessel endothelium?

<p>Short and stumpy trypomastigotes</p> Signup and view all the answers

What is the role of wild animals in the transmission of T.brucei?

<p>They act as reservoirs without showing symptoms</p> Signup and view all the answers

Where does T.brucei multiply by binary fission?

<p>Lymphatic system</p> Signup and view all the answers

What is the transformation process within the tsetse fly for T.brucei?

<p>From metacyclic trypomastigotes to epimastigotes</p> Signup and view all the answers

What is the initial location where a mammalian host gets infected with T.brucei?

<p>Skin tissue</p> Signup and view all the answers

Study Notes

Leishmaniasis Transmission and Hosts

  • Leishmaniasis is spread by the bite of certain types of sandflies, not mosquitoes.
  • The life cycle of Leishmania is completed in three hosts: humans, sandflies, and reservoir hosts (not dogs).

Leishmania Life Cycle

  • Amastigotes transform into the larger promastigote form inside the sandfly's alimentary canal.
  • Promastigotes live extracellularly in the alimentary canal of sandflies.
  • Amastigotes replicate within human macrophages.

Types of Leishmaniasis

  • Cutaneous leishmaniasis is mainly caused by L.tropica, L.major, and L.aethiopica.
  • Visceral leishmaniasis is also known as kala-azar or white fever.
  • Visceral leishmaniasis affects the liver, spleen, bone marrow, and lymph nodes.
  • Post kala-azar dermal leishmaniasis (PKDL) occurs after successful treatment of visceral leishmaniasis and is seen with L.infantum infection.

Diagnosis and Prevention

  • Diagnosis of cutaneous leishmaniasis can be done using DNA testing (PCR).
  • Serological testing is a common diagnostic method used in areas where leishmaniasis is endemic.
  • Leishmania DNA can be detected using PCR tests in diagnosing the disease.
  • Prevention of leishmaniasis includes treating reservoir hosts to control the spread of the disease.

Miscellaneous

  • Mucocutaneous leishmaniasis primarily damages the skin, leading to skin ulcers.
  • Cutaneous leishmaniasis lesions may heal without scarring and not reappear elsewhere.
  • Diffuse cutaneous leishmaniasis heals on its own without leaving scars.
  • Vaccination against leishmaniasis mainly induces a cellular response to control the infection.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Description

Test your knowledge on Blood and Tissue Flagellates, focusing on Leishmania spp. and Leishmaniasis disease spread by specific sandflies. Learn about the geographical distribution of the disease, including the types of sandflies transmitting the Old world leishmaniasis and New world leishmaniasis.

More Like This

Use Quizgecko on...
Browser
Open
Browser
Browser