Podcast
Questions and Answers
Match the Leishmania species with their primary transmission vector:
Match the Leishmania species with their primary transmission vector:
L.donovani, L.infantum, L.tropica, L.major, L.aethiopica = Phlebotomus sandflies L.mexicana, L.braziliensis = Lutzomyia and Psychodopygus sandflies
Match the stage of Leishmania with its morphology:
Match the stage of Leishmania with its morphology:
Amastigote = Spherical or subspherical Promastigote = Pyriform or spindle shape with flagellum
Match the natural reservoir hosts with Leishmania:
Match the natural reservoir hosts with Leishmania:
Humans, dogs, wild rodents = Natural reservoir hosts
Match the location in the sandfly with the transformation of amastigotes to promastigotes:
Match the location in the sandfly with the transformation of amastigotes to promastigotes:
Match the following symptoms with the type of leishmaniasis:
Match the following symptoms with the type of leishmaniasis:
Match the following diagnostic methods with the corresponding test:
Match the following diagnostic methods with the corresponding test:
Match the following terms with their corresponding definitions:
Match the following terms with their corresponding definitions:
Match the following types of leishmaniasis with their characteristics:
Match the following types of leishmaniasis with their characteristics:
Match the following treatments with the type of leishmaniasis they are used for:
Match the following treatments with the type of leishmaniasis they are used for:
Match the following prevention methods with their description:
Match the following prevention methods with their description:
Match the following diagnostic methods with the type of leishmaniasis they are used for:
Match the following diagnostic methods with the type of leishmaniasis they are used for:
Leishmaniasis is spread by the bite of certain types of mosquitoes.
Leishmaniasis is spread by the bite of certain types of mosquitoes.
The term 'New World' refers to Europe and Asia.
The term 'New World' refers to Europe and Asia.
The life cycle of Leishmania is completed in three hosts: humans, sandflies, and dogs.
The life cycle of Leishmania is completed in three hosts: humans, sandflies, and dogs.
Promastigotes live intracellularly in the alimentary canal of sandflies.
Promastigotes live intracellularly in the alimentary canal of sandflies.
In active cases of kala-azar, the Leishmanin test is positive because patients have a strong delayed hypersensitivity response.
In active cases of kala-azar, the Leishmanin test is positive because patients have a strong delayed hypersensitivity response.
Mucocutaneous leishmaniasis primarily damages the skin, leading to skin ulcers.
Mucocutaneous leishmaniasis primarily damages the skin, leading to skin ulcers.
Leishmania parasites replicate extracellularly within human macrophages.
Leishmania parasites replicate extracellularly within human macrophages.
Cutaneous leishmaniasis lesions may heal without scarring and not reappear elsewhere.
Cutaneous leishmaniasis lesions may heal without scarring and not reappear elsewhere.
Vaccination against leishmaniasis mainly induces a humoral response to control the infection.
Vaccination against leishmaniasis mainly induces a humoral response to control the infection.
Prevention of leishmaniasis includes treating reservoir hosts to control the spread of the disease.
Prevention of leishmaniasis includes treating reservoir hosts to control the spread of the disease.
Amastigotes transform into the larger trypomastigote form inside the cells.
Amastigotes transform into the larger trypomastigote form inside the cells.
Cutaneous leishmaniasis is mainly caused by L.tropica, L.major, and L.aethiopica.
Cutaneous leishmaniasis is mainly caused by L.tropica, L.major, and L.aethiopica.
Diffuse cutaneous leishmaniasis heals on its own without leaving scars.
Diffuse cutaneous leishmaniasis heals on its own without leaving scars.
Leishmania invades human macrophages and replicates extracellularly.
Leishmania invades human macrophages and replicates extracellularly.
Diagnosis of cutaneous leishmaniasis can be done using DNA testing (PCR).
Diagnosis of cutaneous leishmaniasis can be done using DNA testing (PCR).
Visceral leishmaniasis is also known as white fever.
Visceral leishmaniasis is also known as white fever.
Visceral leishmaniasis affects the liver, spleen, bone marrow, and lymph nodes.
Visceral leishmaniasis affects the liver, spleen, bone marrow, and lymph nodes.
Post kala-azar dermal leishmaniasis occurs after successful treatment of visceral leishmaniasis.
Post kala-azar dermal leishmaniasis occurs after successful treatment of visceral leishmaniasis.
PKDL is seen with L.infantum infection.
PKDL is seen with L.infantum infection.
Blood count and serum protein estimation are specific diagnostic tests for visceral leishmaniasis.
Blood count and serum protein estimation are specific diagnostic tests for visceral leishmaniasis.
Serological testing is a common diagnostic method used in areas where leishmaniasis is endemic.
Serological testing is a common diagnostic method used in areas where leishmaniasis is endemic.
Leishmania DNA can be detected using PCR tests in diagnosing the disease.
Leishmania DNA can be detected using PCR tests in diagnosing the disease.
Where does the life cycle of T.brucei mostly occur?
Where does the life cycle of T.brucei mostly occur?
Which stage of T.brucei can penetrate the blood vessel endothelium?
Which stage of T.brucei can penetrate the blood vessel endothelium?
What is the role of wild animals in the transmission of T.brucei?
What is the role of wild animals in the transmission of T.brucei?
Where does T.brucei multiply by binary fission?
Where does T.brucei multiply by binary fission?
What is the transformation process within the tsetse fly for T.brucei?
What is the transformation process within the tsetse fly for T.brucei?
What is the initial location where a mammalian host gets infected with T.brucei?
What is the initial location where a mammalian host gets infected with T.brucei?
Study Notes
Leishmaniasis Transmission and Hosts
- Leishmaniasis is spread by the bite of certain types of sandflies, not mosquitoes.
- The life cycle of Leishmania is completed in three hosts: humans, sandflies, and reservoir hosts (not dogs).
Leishmania Life Cycle
- Amastigotes transform into the larger promastigote form inside the sandfly's alimentary canal.
- Promastigotes live extracellularly in the alimentary canal of sandflies.
- Amastigotes replicate within human macrophages.
Types of Leishmaniasis
- Cutaneous leishmaniasis is mainly caused by L.tropica, L.major, and L.aethiopica.
- Visceral leishmaniasis is also known as kala-azar or white fever.
- Visceral leishmaniasis affects the liver, spleen, bone marrow, and lymph nodes.
- Post kala-azar dermal leishmaniasis (PKDL) occurs after successful treatment of visceral leishmaniasis and is seen with L.infantum infection.
Diagnosis and Prevention
- Diagnosis of cutaneous leishmaniasis can be done using DNA testing (PCR).
- Serological testing is a common diagnostic method used in areas where leishmaniasis is endemic.
- Leishmania DNA can be detected using PCR tests in diagnosing the disease.
- Prevention of leishmaniasis includes treating reservoir hosts to control the spread of the disease.
Miscellaneous
- Mucocutaneous leishmaniasis primarily damages the skin, leading to skin ulcers.
- Cutaneous leishmaniasis lesions may heal without scarring and not reappear elsewhere.
- Diffuse cutaneous leishmaniasis heals on its own without leaving scars.
- Vaccination against leishmaniasis mainly induces a cellular response to control the infection.
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Description
Test your knowledge on Blood and Tissue Flagellates, focusing on Leishmania spp. and Leishmaniasis disease spread by specific sandflies. Learn about the geographical distribution of the disease, including the types of sandflies transmitting the Old world leishmaniasis and New world leishmaniasis.
