30 Questions
What is the main requirement for the scaffold's degradation process?
It should break down once new tissue forms
Which type of biomaterial has excellent biocompatibility due to its chemical and structural similarity?
Ceramics
What characteristic makes synthetic polymers preferable for scaffold fabrication?
Controlled degradation characteristics
Which biomaterial type allows host cells to produce their own extracellular matrix?
Natural polymers
Which biomaterial is mentioned as examples for bone regeneration applications?
Tri-calcium phosphate (TCP)
What is a key advantage of natural polymers in tissue engineering?
Allow host cells to produce their own extracellular matrix
What is the primary goal of tissue engineering?
Restore, maintain, and improve tissue functions following damage
Which of the following is NOT an application segment of tissue engineering?
Infectious Diseases
What are the key components involved in tissue engineering?
Scaffolds, Cells, and Biologically Active Molecules
Which field contributes the least to tissue engineering?
Civil Engineering
What role do biomaterials play in tissue engineering?
They are used for therapeutic and diagnostic purposes
Why is there a growing need for regenerative treatments?
Increase in trauma cases and environmental factors
What is the purpose of heparin crosslinking and growth factor binding in the modification of cell-formed decellularized extracellular matrices (ECMs)?
To enhance the vascularization and remodeling abilities of the ECMs
What is the major difference between reseeding an ECM scaffold with ex vivo-cultured cells and directly transplanting a modified ECM into a patient?
Reseeding enhances vascularization, while direct transplantation relies on endogenous tissue regeneration.
What is the primary method by which tissue regeneration occurs when a modified ECM is directly transplanted into a patient?
Instructing resident cells towards target recruitment and specific differentiation
Which type of tissue graft does NOT require cell seeding before transplantation into a patient?
Cancellous bone grafts
Why are autologous tissue grafts considered advantageous for clinical therapeutics?
They provide a natural environment for tissue regeneration
In what way does heparin crosslinking contribute to the modification of decellularized extracellular matrices?
It enhances vascularization ability
What type of polymers can be used as biomaterials in tissue engineering?
Synthetic and naturally occurring polymers
Why is the mimicking of highly organized architectures critical in tissue engineering?
To ensure adequate nutrient transfer and oxygen transport
What is the primary factor determining the successful outcome of organs made from tissue engineering?
Delivery of sufficient nutrients, especially oxygen
What is the purpose of using 3D scaffolds made from oxygen-generating biomaterials in tissue engineering?
To address transport limitations deep within tissues
In tissue engineering, what role do advanced biomaterials play?
They are crucial for achieving successful outcomes
How are biomaterials classified based on functions in tissue engineering?
Hydrogels, injectables, drug delivery capable, surface modified
Which technology provides spatial and temporal control of soluble or insoluble factors for organoids?
Microfluidic chip technology
What type of technology can create organoids with more homogeneous characteristics by facilitating nutrient and oxygen absorption?
Bioreactors
Which approach involves using functional biomaterials and supporting cell types for enhanced stem cell differentiation in organoids?
Co-culture systems
What kind of cells, when used in co-culture systems, can boost the development of in vitro organoid systems?
Endothelial cells
Which technique is utilized to mimic the in vivo environment for organoid development using 3D microenvironments?
3D printing technology
How do microfluidic chip technologies contribute to organoid morphogenesis?
By enabling spatial and temporal control of factors
Test your knowledge on tissue engineering and biomaterials components, functions, applications, and challenges. Learn about the basis of tissue engineering and the different components involved in the process.
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