Biomaterials and Tissue Engineering Quiz

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What is the main requirement for the scaffold's degradation process?

It should break down before cells start fabricating their matrix

It should not coincide with the rate of tissue formation

It should remain intact even after tissue formation

It should break down once new tissue forms (correct)

Which type of biomaterial has excellent biocompatibility due to its chemical and structural similarity?

Natural polymers

Synthetic polymers

Metals

Ceramics (correct)

What characteristic makes synthetic polymers preferable for scaffold fabrication?

Controlled degradation characteristics (correct)

High mechanical stiffness

Biologically active

Allow host cells to produce their own extracellular matrix

Which biomaterial type allows host cells to produce their own extracellular matrix?

Natural polymers Signup and view all the answers

Which biomaterial is mentioned as examples for bone regeneration applications?

Tri-calcium phosphate (TCP) Signup and view all the answers

What is a key advantage of natural polymers in tissue engineering?

Allow host cells to produce their own extracellular matrix Signup and view all the answers

What is the primary goal of tissue engineering?

Restore, maintain, and improve tissue functions following damage Signup and view all the answers

Which of the following is NOT an application segment of tissue engineering?

Infectious Diseases Signup and view all the answers

What are the key components involved in tissue engineering?

Scaffolds, Cells, and Biologically Active Molecules Signup and view all the answers

Which field contributes the least to tissue engineering?

Civil Engineering Signup and view all the answers

What role do biomaterials play in tissue engineering?

They are used for therapeutic and diagnostic purposes Signup and view all the answers

Why is there a growing need for regenerative treatments?

Increase in trauma cases and environmental factors Signup and view all the answers

What is the purpose of heparin crosslinking and growth factor binding in the modification of cell-formed decellularized extracellular matrices (ECMs)?

To enhance the vascularization and remodeling abilities of the ECMs Signup and view all the answers

What is the major difference between reseeding an ECM scaffold with ex vivo-cultured cells and directly transplanting a modified ECM into a patient?

Reseeding enhances vascularization, while direct transplantation relies on endogenous tissue regeneration. Signup and view all the answers

What is the primary method by which tissue regeneration occurs when a modified ECM is directly transplanted into a patient?

Instructing resident cells towards target recruitment and specific differentiation Signup and view all the answers

Which type of tissue graft does NOT require cell seeding before transplantation into a patient?

Cancellous bone grafts Signup and view all the answers

Why are autologous tissue grafts considered advantageous for clinical therapeutics?

They provide a natural environment for tissue regeneration Signup and view all the answers

In what way does heparin crosslinking contribute to the modification of decellularized extracellular matrices?

It enhances vascularization ability Signup and view all the answers

What type of polymers can be used as biomaterials in tissue engineering?

Synthetic and naturally occurring polymers Signup and view all the answers

Why is the mimicking of highly organized architectures critical in tissue engineering?

To ensure adequate nutrient transfer and oxygen transport Signup and view all the answers

What is the primary factor determining the successful outcome of organs made from tissue engineering?

Delivery of sufficient nutrients, especially oxygen Signup and view all the answers

What is the purpose of using 3D scaffolds made from oxygen-generating biomaterials in tissue engineering?

To address transport limitations deep within tissues Signup and view all the answers

In tissue engineering, what role do advanced biomaterials play?

They are crucial for achieving successful outcomes Signup and view all the answers

How are biomaterials classified based on functions in tissue engineering?

Hydrogels, injectables, drug delivery capable, surface modified Signup and view all the answers

Which technology provides spatial and temporal control of soluble or insoluble factors for organoids?

Microfluidic chip technology Signup and view all the answers

What type of technology can create organoids with more homogeneous characteristics by facilitating nutrient and oxygen absorption?

Bioreactors Signup and view all the answers

Which approach involves using functional biomaterials and supporting cell types for enhanced stem cell differentiation in organoids?

Co-culture systems Signup and view all the answers

What kind of cells, when used in co-culture systems, can boost the development of in vitro organoid systems?

Endothelial cells Signup and view all the answers

Which technique is utilized to mimic the in vivo environment for organoid development using 3D microenvironments?

3D printing technology Signup and view all the answers

How do microfluidic chip technologies contribute to organoid morphogenesis?

By enabling spatial and temporal control of factors Signup and view all the answers