Biomaterials and Tissue Engineering Quiz

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Questions and Answers

What is the main requirement for the scaffold's degradation process?

  • It should break down before cells start fabricating their matrix
  • It should not coincide with the rate of tissue formation
  • It should remain intact even after tissue formation
  • It should break down once new tissue forms (correct)

Which type of biomaterial has excellent biocompatibility due to its chemical and structural similarity?

  • Natural polymers
  • Synthetic polymers
  • Metals
  • Ceramics (correct)

What characteristic makes synthetic polymers preferable for scaffold fabrication?

  • Controlled degradation characteristics (correct)
  • High mechanical stiffness
  • Biologically active
  • Allow host cells to produce their own extracellular matrix

Which biomaterial type allows host cells to produce their own extracellular matrix?

<p>Natural polymers (D)</p> Signup and view all the answers

Which biomaterial is mentioned as examples for bone regeneration applications?

<p>Tri-calcium phosphate (TCP) (B)</p> Signup and view all the answers

What is a key advantage of natural polymers in tissue engineering?

<p>Allow host cells to produce their own extracellular matrix (B)</p> Signup and view all the answers

What is the primary goal of tissue engineering?

<p>Restore, maintain, and improve tissue functions following damage (D)</p> Signup and view all the answers

Which of the following is NOT an application segment of tissue engineering?

<p>Infectious Diseases (B)</p> Signup and view all the answers

What are the key components involved in tissue engineering?

<p>Scaffolds, Cells, and Biologically Active Molecules (A)</p> Signup and view all the answers

Which field contributes the least to tissue engineering?

<p>Civil Engineering (B)</p> Signup and view all the answers

What role do biomaterials play in tissue engineering?

<p>They are used for therapeutic and diagnostic purposes (A)</p> Signup and view all the answers

Why is there a growing need for regenerative treatments?

<p>Increase in trauma cases and environmental factors (D)</p> Signup and view all the answers

What is the purpose of heparin crosslinking and growth factor binding in the modification of cell-formed decellularized extracellular matrices (ECMs)?

<p>To enhance the vascularization and remodeling abilities of the ECMs (C)</p> Signup and view all the answers

What is the major difference between reseeding an ECM scaffold with ex vivo-cultured cells and directly transplanting a modified ECM into a patient?

<p>Reseeding enhances vascularization, while direct transplantation relies on endogenous tissue regeneration. (A)</p> Signup and view all the answers

What is the primary method by which tissue regeneration occurs when a modified ECM is directly transplanted into a patient?

<p>Instructing resident cells towards target recruitment and specific differentiation (C)</p> Signup and view all the answers

Which type of tissue graft does NOT require cell seeding before transplantation into a patient?

<p>Cancellous bone grafts (A)</p> Signup and view all the answers

Why are autologous tissue grafts considered advantageous for clinical therapeutics?

<p>They provide a natural environment for tissue regeneration (D)</p> Signup and view all the answers

In what way does heparin crosslinking contribute to the modification of decellularized extracellular matrices?

<p>It enhances vascularization ability (B)</p> Signup and view all the answers

What type of polymers can be used as biomaterials in tissue engineering?

<p>Synthetic and naturally occurring polymers (A)</p> Signup and view all the answers

Why is the mimicking of highly organized architectures critical in tissue engineering?

<p>To ensure adequate nutrient transfer and oxygen transport (B)</p> Signup and view all the answers

What is the primary factor determining the successful outcome of organs made from tissue engineering?

<p>Delivery of sufficient nutrients, especially oxygen (A)</p> Signup and view all the answers

What is the purpose of using 3D scaffolds made from oxygen-generating biomaterials in tissue engineering?

<p>To address transport limitations deep within tissues (B)</p> Signup and view all the answers

In tissue engineering, what role do advanced biomaterials play?

<p>They are crucial for achieving successful outcomes (B)</p> Signup and view all the answers

How are biomaterials classified based on functions in tissue engineering?

<p>Hydrogels, injectables, drug delivery capable, surface modified (A)</p> Signup and view all the answers

Which technology provides spatial and temporal control of soluble or insoluble factors for organoids?

<p>Microfluidic chip technology (A)</p> Signup and view all the answers

What type of technology can create organoids with more homogeneous characteristics by facilitating nutrient and oxygen absorption?

<p>Bioreactors (D)</p> Signup and view all the answers

Which approach involves using functional biomaterials and supporting cell types for enhanced stem cell differentiation in organoids?

<p>Co-culture systems (C)</p> Signup and view all the answers

What kind of cells, when used in co-culture systems, can boost the development of in vitro organoid systems?

<p>Endothelial cells (D)</p> Signup and view all the answers

Which technique is utilized to mimic the in vivo environment for organoid development using 3D microenvironments?

<p>3D printing technology (C)</p> Signup and view all the answers

How do microfluidic chip technologies contribute to organoid morphogenesis?

<p>By enabling spatial and temporal control of factors (A)</p> Signup and view all the answers

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