10 Questions
What is a limitation of using serum creatinine as a marker of kidney injury?
It is affected by muscle bulk
Which of the following biomarkers is measured in both blood and urine?
NGAL
What is a limitation of serum creatinine that is addressed by newer biomarkers?
It has a time lag before it rises
Which of the following biomarkers is not measured in the urine?
Cystatin C
What is the advantage of using newer biomarkers, such as NGAL and Cystatin C, over serum creatinine?
They have a faster response time
What is the function of the filtration barrier in the glomerulus?
To provide both anatomic and electric barriers to the passage of macromolecules from the capillary lumen into the Bowman space
What are the three components that make up the filtration barrier in the glomerulus?
Endothelium, glomerular basement membrane, and foot processes of podocytes
What type of barrier does the filtration barrier in the glomerulus provide?
Both anatomic and electric barriers
What is the purpose of the foot processes of podocytes in the glomerulus?
To increase the surface area for filtration
What is the role of the glomerular basement membrane in the filtration barrier?
To provide a negatively charged surface for filtration
Study Notes
Limitations of Serum Creatinine
- Serum creatinine has limitations as a marker of kidney injury, including muscle bulk and time lag before it rises.
Newer Biomarkers for AKI
- Neutrophil Gelatinase Associated Lipocalin (NGAL) is a preferred biomarker for AKI, measurable in both blood and urine.
- AKIM-1 is a preferred biomarker for AKI, measurable in urine.
- Cystatin C is a preferred biomarker for AKI, measurable in blood.
- IL-18 is a preferred biomarker for AKI.
Glomerular Filtration Barrier
- Comprised of three components: endothelium of glomerular capillaries, glomerular basement membrane, and foot process of the podocyte
- These three components provide a dual barrier to the passage of macromolecules from the capillary lumen into the Bowman space
- This dual barrier is both anatomical and electrical
This quiz covers the limitations of serum creatinine as a marker of kidney injury and introduces newer biomarkers for AKI, including NGAL, AKIM-1, Cystatin C, and IL-18.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
