Recent Lessons

Show all results for ""

Feature Overview

Ace your exams with our all-in-one platform for creating and sharing quizzes and tests.

Quizzes

Create quizzes and tests automatically from your content using AI.

Flashcards

Automatically turn your notes into digital flashcards.

Share, Export & Embed

Share with classmates or export to Excel and your learning management system.

Stats & Reporting

Auto-grading quizzes and tests with detailed stats and reports.

Mobile Apps

The smarter way to study – wherever you are.

Pricing

Search...

10 Questions

6 Views

Biomarkers for Acute Kidney Injury

Choose a study mode

Play Quiz

Study Flashcards

Spaced Repetition

Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is a limitation of using serum creatinine as a marker of kidney injury?

It is only present in the urine

It is a specific marker for AKI

It is affected by muscle bulk (correct)

It is a highly sensitive biomarker

Which of the following biomarkers is measured in both blood and urine?

IL-18

Cystatin C

NGAL (correct)

AKIM-1

What is a limitation of serum creatinine that is addressed by newer biomarkers?

It is only present in the blood

It has a time lag before it rises (correct)

It is not affected by muscle bulk

It is not specific to kidney injury

Which of the following biomarkers is not measured in the urine?

Cystatin C Signup and view all the answers

What is the advantage of using newer biomarkers, such as NGAL and Cystatin C, over serum creatinine?

They have a faster response time Signup and view all the answers

What is the function of the filtration barrier in the glomerulus?

To provide both anatomic and electric barriers to the passage of macromolecules from the capillary lumen into the Bowman space Signup and view all the answers

What are the three components that make up the filtration barrier in the glomerulus?

Endothelium, glomerular basement membrane, and foot processes of podocytes Signup and view all the answers

What type of barrier does the filtration barrier in the glomerulus provide?

Both anatomic and electric barriers Signup and view all the answers

What is the purpose of the foot processes of podocytes in the glomerulus?

To increase the surface area for filtration Signup and view all the answers

What is the role of the glomerular basement membrane in the filtration barrier?

To provide a negatively charged surface for filtration Signup and view all the answers

Study Notes

Limitations of Serum Creatinine

Serum creatinine has limitations as a marker of kidney injury, including muscle bulk and time lag before it rises.

Newer Biomarkers for AKI

Neutrophil Gelatinase Associated Lipocalin (NGAL) is a preferred biomarker for AKI, measurable in both blood and urine.
AKIM-1 is a preferred biomarker for AKI, measurable in urine.
Cystatin C is a preferred biomarker for AKI, measurable in blood.
IL-18 is a preferred biomarker for AKI.

Glomerular Filtration Barrier

Comprised of three components: endothelium of glomerular capillaries, glomerular basement membrane, and foot process of the podocyte
These three components provide a dual barrier to the passage of macromolecules from the capillary lumen into the Bowman space
This dual barrier is both anatomical and electrical

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Description

This quiz covers the limitations of serum creatinine as a marker of kidney injury and introduces newer biomarkers for AKI, including NGAL, AKIM-1, Cystatin C, and IL-18.