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What is the primary function of the cytoskeleton within a cell?
What is the primary function of the cytoskeleton within a cell?
The cytoskeleton supports the cell and its organelles while facilitating movement and changes in cell shape.
Describe the role of microtubules in the cell.
Describe the role of microtubules in the cell.
Microtubules serve as an internal scaffold for the cell, transporting materials, and aiding in cell division.
What separates the interior of the nucleus from the cytoplasm?
What separates the interior of the nucleus from the cytoplasm?
The nuclear envelope, which is a bilayer membrane, separates the nucleus from the cytoplasm.
How does chromatin relate to chromosome structure during cell division?
How does chromatin relate to chromosome structure during cell division?
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What is the significance of the nucleolus in the nucleus?
What is the significance of the nucleolus in the nucleus?
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What structure in the respiratory tract helps move mucus out of the lungs?
What structure in the respiratory tract helps move mucus out of the lungs?
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How do flagella differ from cilia in terms of structure and function?
How do flagella differ from cilia in terms of structure and function?
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What is the primary function of microvilli in absorptive cells?
What is the primary function of microvilli in absorptive cells?
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What is histology and why is it important?
What is histology and why is it important?
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Describe the first two steps in the preparation of tissue for microscopic examination.
Describe the first two steps in the preparation of tissue for microscopic examination.
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What are the main components of a human cell that contribute to its structure?
What are the main components of a human cell that contribute to its structure?
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Explain the role of the plasma membrane in a cell.
Explain the role of the plasma membrane in a cell.
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What is the function of ribosomes in human cells?
What is the function of ribosomes in human cells?
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Describe the fluid mosaic model of the plasma membrane.
Describe the fluid mosaic model of the plasma membrane.
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What is the cytoplasm and what does it contain?
What is the cytoplasm and what does it contain?
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What are cytoplasmic inclusions and their significance?
What are cytoplasmic inclusions and their significance?
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How do cells communicate with each other through the plasma membrane?
How do cells communicate with each other through the plasma membrane?
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What distinguishes the hydrophilic and hydrophobic regions in the plasma membrane's structure?
What distinguishes the hydrophilic and hydrophobic regions in the plasma membrane's structure?
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What is the main function of ribosomes in a cell?
What is the main function of ribosomes in a cell?
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Describe the differences in structure between rough and smooth endoplasmic reticulum.
Describe the differences in structure between rough and smooth endoplasmic reticulum.
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What role does the Golgi apparatus play in a cell?
What role does the Golgi apparatus play in a cell?
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How do lysosomes function within the cell?
How do lysosomes function within the cell?
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What is the primary function of mitochondria in a cell?
What is the primary function of mitochondria in a cell?
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Explain the structure of centrioles and their role during cell division.
Explain the structure of centrioles and their role during cell division.
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What is the function of cilia on the surface of certain cells?
What is the function of cilia on the surface of certain cells?
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What is the significance of the centromere in chromatids?
What is the significance of the centromere in chromatids?
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Describe the composition of ribosomes.
Describe the composition of ribosomes.
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How does the structure of mitochondria aid in its function?
How does the structure of mitochondria aid in its function?
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What is the primary function of the basement membrane in epithelial tissue?
What is the primary function of the basement membrane in epithelial tissue?
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Define simple squamous epithelium and provide one function.
Define simple squamous epithelium and provide one function.
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What characterizes pseudostratified epithelial tissue?
What characterizes pseudostratified epithelial tissue?
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List two locations where simple cuboidal epithelium can be found.
List two locations where simple cuboidal epithelium can be found.
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What are the four shapes of epithelial cells and one example location for each?
What are the four shapes of epithelial cells and one example location for each?
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Describe the regenerative capability of epithelial tissue.
Describe the regenerative capability of epithelial tissue.
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What is the difference between stratified and simple epithelial tissue?
What is the difference between stratified and simple epithelial tissue?
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What tissue type is found exclusively in the urinary system and what is its primary feature?
What tissue type is found exclusively in the urinary system and what is its primary feature?
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What is the plasma membrane's primary role in a cell?
What is the plasma membrane's primary role in a cell?
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Describe the fluid mosaic model of the plasma membrane in brief.
Describe the fluid mosaic model of the plasma membrane in brief.
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How do the organelles within the cytoplasm contribute to cell function?
How do the organelles within the cytoplasm contribute to cell function?
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What distinguishes hydrophilic and hydrophobic regions in the membrane structure?
What distinguishes hydrophilic and hydrophobic regions in the membrane structure?
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What role do carbohydrates play in the structure of the plasma membrane?
What role do carbohydrates play in the structure of the plasma membrane?
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Explain the function of mitochondria within human cells.
Explain the function of mitochondria within human cells.
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What is the significance of cell communication in cellular functions?
What is the significance of cell communication in cellular functions?
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Identify two types of cytoplasmic inclusions and their importance.
Identify two types of cytoplasmic inclusions and their importance.
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What is the primary role of intermediate filaments in a cell?
What is the primary role of intermediate filaments in a cell?
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How do microfilaments contribute to cellular movement?
How do microfilaments contribute to cellular movement?
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Explain the significance of the nuclear envelope in the nucleus.
Explain the significance of the nuclear envelope in the nucleus.
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What is chromatin and what role does it play during cell division?
What is chromatin and what role does it play during cell division?
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Describe the function of the nucleolus within the nucleus.
Describe the function of the nucleolus within the nucleus.
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How does the abundance of organelles relate to the function of a cell?
How does the abundance of organelles relate to the function of a cell?
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What role do microtubules play during cell division?
What role do microtubules play during cell division?
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In what way do the cytoskeleton's components work together?
In what way do the cytoskeleton's components work together?
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What is the relationship between histones and chromatin?
What is the relationship between histones and chromatin?
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How do organelles contribute to the overall functionality of a cell?
How do organelles contribute to the overall functionality of a cell?
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What is the primary responsibility of the heart in relation to blood circulation?
What is the primary responsibility of the heart in relation to blood circulation?
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Describe the myocardium and its significance in the heart.
Describe the myocardium and its significance in the heart.
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What distinguishes cardiac muscle from smooth muscle in terms of structure?
What distinguishes cardiac muscle from smooth muscle in terms of structure?
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What are the two types of smooth muscle contractions affecting blood flow?
What are the two types of smooth muscle contractions affecting blood flow?
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Identify the main components of nervous tissue.
Identify the main components of nervous tissue.
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What is the role of dendrites in a neuron?
What is the role of dendrites in a neuron?
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Explain the function of the smooth muscle in the blood vessels.
Explain the function of the smooth muscle in the blood vessels.
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How does cardiomyocyte structure contribute to heart function?
How does cardiomyocyte structure contribute to heart function?
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Why are neuroglia important in the nervous system?
Why are neuroglia important in the nervous system?
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What is the primary control mechanism for both cardiac and smooth muscles?
What is the primary control mechanism for both cardiac and smooth muscles?
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What are the primary functions of the mitochondria within a cell?
What are the primary functions of the mitochondria within a cell?
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Why do some muscle cells, such as skeletal muscle cells, have multiple nuclei?
Why do some muscle cells, such as skeletal muscle cells, have multiple nuclei?
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What is the role of the Golgi apparatus in the cell?
What is the role of the Golgi apparatus in the cell?
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How do lysosomes contribute to cellular homeostasis?
How do lysosomes contribute to cellular homeostasis?
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What functions are associated with the rough and smooth endoplasmic reticulum?
What functions are associated with the rough and smooth endoplasmic reticulum?
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What are the colors of the stains used in hematoxylin and eosin and what do they stain?
What are the colors of the stains used in hematoxylin and eosin and what do they stain?
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How does the plane of section affect the appearance of tissue in a microscopic image?
How does the plane of section affect the appearance of tissue in a microscopic image?
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Name the four primary tissue types found in all organs of the body.
Name the four primary tissue types found in all organs of the body.
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What is the primary function of epithelial tissue?
What is the primary function of epithelial tissue?
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What are the distinct surfaces of epithelial tissue known as?
What are the distinct surfaces of epithelial tissue known as?
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What role does connective tissue play in the body?
What role does connective tissue play in the body?
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Identify the type of muscle tissue responsible for movement.
Identify the type of muscle tissue responsible for movement.
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What is the function of nervous tissue?
What is the function of nervous tissue?
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What is glandular epithelium and what is its main function?
What is glandular epithelium and what is its main function?
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Study Notes
The Cell
- The fundamental building block of all living organisms, including humans.
- Composed of a plasma membrane, cytoplasm, and nucleus.
Cell Functions
- Metabolism & Energy Use: Undertaking all chemical reactions within a cell.
- Synthesis: Creation of new molecules.
- Communication: Exchanging chemical or electrical signals with other cells.
- Reproduction & Inheritance: Copying and passing on genetic material through mitosis or meiosis.
Human Cells
- Contain structures called organelles: Plasma membrane, cytoplasm, cytoskeleton, nucleus, ribosomes, Golgi apparatus, lysosomes, mitochondria, centrioles, cilia, microvilli.
- The abundance of each organelle varies, depending on the cell's function.
Plasma Membrane
- Also called the cell membrane, sarcolemma or plasmalemma.
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Functions:
- Encloses and supports cell contents.
- Regulates entry and exit of materials.
- Controls intracellular and extracellular environments.
- Participates in cell-to-cell communication.
- Creates a charge difference (membrane potential) across it.
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Structure:
- Lipid bilayer (phospholipid bilayer and cholesterol) : Provides cell flexibility. Hydrophilic heads face the water-based environment inside and outside the cell; hydrophobic tails face each other within the membrane.
- Carbohydrates: 4-8%
- Proteins: Responsible for various functions, including transport, signaling, and structural support.
- Fluid mosaic model: Describes the membrane's dynamic nature, where components are constantly moving.
- Glycocalyx: Outer cell surface, composed of:
- Glycoproteins (proteins and carbohydrates).
- Glycolipids (lipids and carbohydrates).
- Carbohydrates
Cytoplasm
- Fluid between the plasma membrane and the nucleus.
- Contains the organelles.
- Cytosol: The viscous, watery solution within the cytoplasm, containing dissolved ions, proteins, and other molecules.
- Cytoplasmic Inclusions: Aggregates of chemicals inside the cell or transported into the cell (e.g., melanin).
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Cytoskeleton: Provides structural support and enables movement of organelles and changes in cell shape.
- Microtubules: Hollow, tubulin-based structures: Internal scaffolding, transport, cell division.
- Microfilaments: Actin-based fibers: Structure, support for microvilli, contractility, movement.
- Intermediate Filaments: Provide mechanical strength.
Nucleus and cytoplasmic organelles
- Specialized structures with specific functions.
- Most have membranes separating their interiors from the cytoplasm.
- The abundance of each organelle is related to the cell's structure and function.
Nucleus
- Function: The cell's control center, containing DNA that carries the genetic code for the cell’s structure and functions.
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Structure:
- Nuclear envelope: A bilayered membrane surrounding the nucleus, with pores allowing communication between the nucleus and cytoplasm.
- Nucleoplasm: Jelly-like substance filling the nucleus.
- Nucleolus: Produces ribosomes.
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Chromosomes:
- Chromatin: DNA complexed with proteins (histones).
- Chromosomes: During cell division, chromatin condenses into paired chromatids joined at a centromere.
Ribosomes
- Function: Sites of protein synthesis, assembling amino acids into proteins.
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Structure: Two subunits: large and small.
- Free ribosomes: Float in the cytoplasm.
- Membrane-bound ribosomes: Attached to the endoplasmic reticulum.
Endoplasmic reticulum
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Structure: Network of interconnected sacs and tubules near the nucleus.
- Rough endoplasmic reticulum: Contains ribosomes.
- Smooth endoplasmic reticulum: Lacks ribosomes.
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Functions:
- Rough endoplasmic reticulum: Synthesis and modification of proteins.
- Smooth endoplasmic reticulum: Synthesis of lipids, steroids, and carbohydrates. Detoxification of harmful substances (drugs). Breakdown of glycogen into glucose.
Golgi apparatus
- Structure: Stacks of flattened, membranous sacs with cisternae.
- Secretory vesicles: Release proteins from the Golgi apparatus.
- Function: Modifies, packages, and distributes proteins and lipids made in the rough endoplasmic reticulum for secretion or internal use by the cell.
Lysosomes
- Structure: Membrane-bound vesicles formed at the Golgi apparatus, containing digestive enzymes.
- Function: The cell’s demolition crew. Digest molecules (nucleic acids, proteins, lipids, carbohydrates, etc.) that are no longer needed by the cell.
Mitochondria
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Structure: Two membranes (outer and inner), with an intermembrane space between them.
- Matrix: The space inside the inner membrane folds, important for ATP synthesis.
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Function: “Powerhouses” of the cell.
- Increase in number when cell energy requirements increase (e.g., cardiac and nerve cells, skeletal muscle cells in response to exercise).
- Produce ATP (adenosine triphosphate), the cell’s energy currency.
Centrioles
- Structure: Barrel-shaped organelles oriented at right angles to each other. The wall is composed of microtubules. Two centrioles are located in the centrosome (center of the cell).
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Function: Cell division.
- Meiotic spindles grow from the centrioles.
- They move to opposite ends of the cell.
Cilia
- Structure: Whip-like, motile extensions projecting from the surface of certain cells.
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Function: Movement of substances across the cell surface.
- E.g., cilia lining the respiratory tract, moving mucus out of the lungs.
- E.g., cilia in the fallopian tubes, moving the egg from the ovary to the uterus.
Flagella
- Structure: Similar to cilia but longer. Found on human sperm cells (one flagellum per sperm cell).
- Function: Mobility.
Microvilli
- Structure: Extensions of the plasma membrane, numerous on each cell, about 1/10th-1/20th the size of cilia. Non-motile.
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Function: Increase the cell’s surface area.
- E.g., absorptive cells of the intestine or kidney tubules.
Histology
- The study of tissues.
- Involves examining thin, stained slices of tissue under a microscope.
Body Fluids
- Intracellular: Fluid inside cells.
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Extracellular: Fluid outside cells.
- Intercellular: Fluid between cells.
- Intervascular: Fluid within blood vessels.
Tissue Preparation
- 1. Removal: Biopsy or autopsy.
- 2. Fixation: Preserves tissue using paraformaldehyde to prevent breakdown.
- 3. Embedding: Incorporates tissue into a medium (wax or frozen) for sectioning.
- 4. Slicing: Thin tissue sections are cut and mounted onto a slide.
Basement Membrane (Basal Lamina)
- Structure: Connects the epithelium to underlying connective tissue.
- Characteristics: Avascular (no blood supply) but innervated (has nerves).
- Function: Provides a diffusion pathway for nutrients and substances from the connective tissue to the epithelium.
- Regeneration: Epithelial cells are constantly dividing and regenerating from the basal (bottom) layer.
Epithelial Tissue Classification
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Cell Layers:
- Simple: One layer.
- ** Stratified:** More than one layer, with different shapes.
- Pseudostratified: Appears to have multiple layers but is actually one layer, with all cell bases on the basement membrane.
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Cell Shapes:
- Squamous: Flat, thin cells.
- Cuboidal: Cube-shaped cells.
- Columnar: Tall, column-shaped cells.
- Transitional: Cells that can change shape from tall to flat, found only in the urinary system.
Simple Squamous Epithelium
- Structure: A single layer of flattened cells with sparse cytoplasm.
- Functions: Diffusion, filtration, some secretion.
- Locations: Alveoli of the lungs, kidney glomeruli, serous membranes of the pleura, pericardium, and peritoneum.
Simple Cuboidal Epithelium
- Structure: One layer of cube-shaped cells on a basement membrane, some with microvilli or cilia.
- Functions: Absorption, secretion, movement.
- Locations: Kidney tubules, bronchioles.
Simple Columnar Epithelium
- Structure: Single layer of tall, column-shaped cells with round/oval nuclei.
The Cell
- The structural and functional unit of all living organisms
- Composed of plasma membrane, cytoplasm containing organelles, and a nucleus
Functional Characteristics of Cells
- Cell Metabolism and Energy Use: All chemical reactions carried out within the cell
- Synthesis of Molecules: Cells create molecules
- Communication: Cell-to-cell communication through chemical or electrical messages
- Reproduction and Inheritance: Cells divide and reproduce through mitosis or meiosis
Human Cell
- Consists of various organelles, including:
- Plasma membrane
- Cytoplasm
- Cytoskeletons
- Nucleus
- Ribosomes
- Golgi apparatus
- Lysosomes
- Mitochondria
- Centrioles
- Cilia
- Microvilli
- The quantity of each organelle varies based on the cell's function
Plasma Membrane
- Also known as the cell membrane, sarcolemma or plasmalemma
- Functions:
- Encloses and supports cellular contents
- Controls what enters and exits the cell
- Regulates intracellular and extracellular material
- Facilitates intercellular communication
- Generates a charge difference (membrane potential)
- Structure:
- Lipid bilayer (phospholipid bilayer and cholesterol): Provides flexibility to the cell
- Polar heads facing water are hydrophilic (water-loving)
- Non-polar tails facing each other are hydrophobic (water-fearing)
- Carbohydrates
- Protein
- Fluid mosaic model
- Glycocalyx (outer surface of the membrane):
- Glycoproteins (proteins and carbohydrates)
- Glycolipids (lipids and carbohydrates)
- Carbohydrates
- Lipid bilayer (phospholipid bilayer and cholesterol): Provides flexibility to the cell
Cytoplasm
- Cellular fluid outside the nucleus and within the plasma membrane
- Contains all organelles
- Cytosol: viscous solution containing water, ions, and proteins
- Cytoplasmic inclusion: Aggregates of chemicals produced within the cell or transported into the cell (e.g. melanin)
-
Cytoskeleton: Supports the cell and its organelles
- Microtubules: Hollow, made of tubulin. Internal scaffold, involved in transport and cell division
- Microfilaments: Actin, provide structure, support for microvilli, contractility, and movement
- Intermediate filaments: Provide mechanical strength
Nucleus and Cytoplasmic Organelles
- Specialized structures with specific functions
- Most have membranes that separate the interior from the cytoplasm
- Abundance of each organelle is related to the cell's specific function
Nucleus
- Function:
- Control center of the cell
- Deoxyribonucleic Acid (DNA) carries the code for the cell's structural and functional characteristics
- Structure:
- Nuclear envelope: Bilayer membrane surrounding the nucleus, contains pores
- Nucleoplasm
- Nucleolus: Primarily produces ribosomes
- Chromosome structure:
- Chromatin: DNA complexed with proteins (histones)
- During cell division, chromatin divides into pairs of chromatids called chromosomes.
Hematoxylin and Eosin (A&E)
- Staining technique used in microscopy
- Hematoxylin stains nuclei purple due to its affinity for nucleic acids.
- Eosin stains other cell structures (cytoplasm) pink.
Points to Consider when Viewing Histological Images
- The plane of section can significantly affect the appearance of the tissue.
- Magnification of the image is crucial for interpretation.
### Primary Tissues
- All organs contain all four primary tissues:
- Epithelial: Covers and protects (covering and lining epithelium, glandular epithelium (secretory))
- Connective: Supports (bone and cartilage)
- Muscle: Movement (contracts and causes force)
- Nervous: Control (neurons and supporting cells govern body functions)
Epithelial Tissue
- Covers and protects
- Distinct cell surfaces:
- Free surface (top)
- Lateral surface
- Basal surface
Connective Tissue
- Supports, connects, and protects other tissues and organs
- Diverse cell types embedded in an extracellular matrix
- Examples: bone, cartilage, blood, adipose tissue
### Muscle Tissue
- Responsible for movement
- Three types:
- Skeletal muscle: Voluntary control, striated, responsible for body movement
- Cardiac muscle: Involuntary control, striated, forms the heart
- Smooth muscle: Involuntary control, non-striated, found in walls of organs and tubes
### Nervous Tissue
- Composes the nervous system (brain, spinal cord, nerves)
- Primary components:
- Neurons (nerve cells): Conduct action potentials
- Supporting cells (neuroglia): Nourish, insulate, and protect neurons
Organelle Functions
- Nucleus: Control center of the cell, codes for proteins.
- Nucleolus: Stores DNA and genetic material, produces ribosomes.
- Mitochondria: Powerhouse of the cell, responsible for cellular respiration and ATP production.
- Ribosomes: Site of protein synthesis.
- Lysosomes: Digest molecules (waste material).
- Rough Endoplasmic Reticulum (RER): Site of protein synthesis and modification (contains ribosomes).
- Smooth Endoplasmic Reticulum (SER): Site of steroid, carbohydrate, and lipid synthesis. Also involved in detoxification.
- Centrosome: Creates spindle fibers during cell division.
- Golgi apparatus: Modifies, packages, and distributes proteins and lipids
- Plasma membrane: Controls what goes in and out of the cell, encloses and supports cellular contents
Cells with High Energetic Needs
- Muscle cells (especially cardiac and skeletal muscle)
- Kidney cells
- Liver cells
Cells with Multiple Nuclei
- Skeletal muscle cells
- Osteoclast cells
- Why? These cells require more regulation because they have more functions
Cells with High Hormone Production
- Cells in the ovaries and testes
- Adrenal glands
- Liver
Cells with High Secretory Activity
- Pancreatic beta cells (insulin)
- Goblet cells (mucus)
- Stomach chief cells (digestive enzymes)
- Plasma cells (antibodies)
Parts of the Cytoplasm
- Cytoskeleton: Supports the cell and its organelles.
- Cytosol: The fluid portion of the cytoplasm that contains ions, proteins, and water.
- Cytoplasm: The entire internal contents of the cell, excluding the nucleus.
### Key Features of Muscle Tissues
- Skeletal muscle: Very compact cells, makes up muscles that are consciously controlled by the brain for movement.
- Cardiac muscle: Responsible for pumping blood around the body.
- Smooth muscle: Found within organs that require movement, such as the stomach and intestines.
### Key Features of Connective Tissue
- Supporting cells: Provide support and protection to other tissues and organs.
- Extracellular matrix: Contains a variety of cells embedded within.
### Key Features of Nervous Tissue
- Comprises the nervous system, responsible for information processing.
- Characterized by long, thin nerve cells that extend across long distances to conduct nerve impulses to and from the brain.
- Found in the brain and spinal cord.
- Two main components:
- Neurons: Generate and conduct action potentials.
- Supporting Cells (Neuroglia): Nourish, insulate, and protect neurons.
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Description
Explore the fundamental unit of life in this quiz on cells. Understand their structures, functions, and the specific roles of organelles in human cells. Test your knowledge on metabolism, synthesis, and cell communication.