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Questions and Answers
Inductive reasoning is ideally used for testing biological hypotheses.
Inductive reasoning is ideally used for testing biological hypotheses.
False (B)
What is the process called where specific observations are synthesized to produce a general statement?
What is the process called where specific observations are synthesized to produce a general statement?
Induction
The process of making predictions based on a biological hypothesis is part of __________ science.
The process of making predictions based on a biological hypothesis is part of __________ science.
hypothesis-testing
Match the following concepts with their definitions:
Match the following concepts with their definitions:
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What is a major advantage of manipulative studies over observational studies?
What is a major advantage of manipulative studies over observational studies?
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Confounding variables are always known to researchers.
Confounding variables are always known to researchers.
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What is the purpose of a control in an experimental procedure?
What is the purpose of a control in an experimental procedure?
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In a manipulative study, the researcher actively changes the ______ variable.
In a manipulative study, the researcher actively changes the ______ variable.
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Match the following terms to their definitions:
Match the following terms to their definitions:
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What is the primary aim of the scientific method?
What is the primary aim of the scientific method?
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Hypotheses can be proven to be true in the scientific method.
Hypotheses can be proven to be true in the scientific method.
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What are the two types of science discussed?
What are the two types of science discussed?
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The scientific method is an approach to knowledge acquisition that relies on _____ and experimentation.
The scientific method is an approach to knowledge acquisition that relies on _____ and experimentation.
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What role do controls play in an experiment?
What role do controls play in an experiment?
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Hypothesis-testing science is primarily focused on observing patterns without manipulating variables.
Hypothesis-testing science is primarily focused on observing patterns without manipulating variables.
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What is the key difference between a hypothesis and a theory?
What is the key difference between a hypothesis and a theory?
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What is one potential consequence of folate deficiency in pregnant women?
What is one potential consequence of folate deficiency in pregnant women?
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Melanin primarily evolved to protect against skin cancer caused by UV radiation.
Melanin primarily evolved to protect against skin cancer caused by UV radiation.
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Melanin helps reduce the loss of folate due to _____-induced degradation.
Melanin helps reduce the loss of folate due to _____-induced degradation.
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What is another name that could better describe 'hypothesis testing' according to recent insights?
What is another name that could better describe 'hypothesis testing' according to recent insights?
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Researchers seeking to confirm their existing beliefs are conducting legitimate science.
Researchers seeking to confirm their existing beliefs are conducting legitimate science.
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What must scientists strive to be to ensure their findings are unbiased?
What must scientists strive to be to ensure their findings are unbiased?
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Knowledge acquisition requires researchers to be _____, guided by reason and employing the scientific method.
Knowledge acquisition requires researchers to be _____, guided by reason and employing the scientific method.
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Match the following terms with their descriptions:
Match the following terms with their descriptions:
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Which of the following describes the approach of a researcher who aims to disprove a hypothesis?
Which of the following describes the approach of a researcher who aims to disprove a hypothesis?
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Observations that suggest a flat Earth can also support the idea of a spherical Earth.
Observations that suggest a flat Earth can also support the idea of a spherical Earth.
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What should researchers do when they find evidence that contradicts their hypothesis?
What should researchers do when they find evidence that contradicts their hypothesis?
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What defines a scientific theory?
What defines a scientific theory?
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Humans and chimpanzees do not share a common ancestor.
Humans and chimpanzees do not share a common ancestor.
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What role does melanin play in human skin?
What role does melanin play in human skin?
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The hypothesis suggests that human skin color variation evolved from selection for increased __________ in areas of high UV exposure.
The hypothesis suggests that human skin color variation evolved from selection for increased __________ in areas of high UV exposure.
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Match the following concepts to their descriptions:
Match the following concepts to their descriptions:
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Why did early humans lose much of their body hair?
Why did early humans lose much of their body hair?
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Dark skin offers more protection from UV-induced DNA mutations than lighter skin.
Dark skin offers more protection from UV-induced DNA mutations than lighter skin.
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What is the impact of UV light on DNA?
What is the impact of UV light on DNA?
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Flashcards
Scientific Method
Scientific Method
A way of acquiring knowledge based on evidence collected through observation and experimentation.
Descriptive Science
Descriptive Science
Describes patterns in the natural world.
Hypothesis-Testing Science
Hypothesis-Testing Science
Explains patterns observed in the natural world.
Hypothesis vs. Prediction vs. Theory
Hypothesis vs. Prediction vs. Theory
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Science vs. Non-science
Science vs. Non-science
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Confounding Variables
Confounding Variables
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Controls
Controls
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Inferential Strength and Extrapolation (studies)
Inferential Strength and Extrapolation (studies)
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Primary production
Primary production
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Limiting nutrient
Limiting nutrient
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Hypothesis
Hypothesis
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Inductive reasoning
Inductive reasoning
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Scientific Theory
Scientific Theory
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Human skin color evolution
Human skin color evolution
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UV radiation
UV radiation
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Melanin
Melanin
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Skin Cancer
Skin Cancer
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Common ancestor
Common ancestor
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Evolutionary selection
Evolutionary selection
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Falsifiable hypotheses
Falsifiable hypotheses
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Deductive predictions
Deductive predictions
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Statistical inference
Statistical inference
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Rationality (in science)
Rationality (in science)
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Skepticism in science
Skepticism in science
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Objective research
Objective research
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Materialism in science
Materialism in science
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Manipulative Study
Manipulative Study
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Inferential Strength
Inferential Strength
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Control (in experiment)
Control (in experiment)
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Independent Variable
Independent Variable
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Folate's Role in Pregnancy
Folate's Role in Pregnancy
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Folate Deficiency Consequences
Folate Deficiency Consequences
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Melanin and UV-induced Folate Breakdown
Melanin and UV-induced Folate Breakdown
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Melanin: Weak Cancer Protection
Melanin: Weak Cancer Protection
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Skin Cancer: Weak Selective Pressure
Skin Cancer: Weak Selective Pressure
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Study Notes
The Scientific Method
- Biology is the study of the structure and behaviour of the natural world through observation and experimentation.
- The scientific method is an approach to acquiring knowledge based on evidence (data from observation and experimentation).
Learning Objectives
- Define science and the scientific method, and explain its importance.
- Distinguish different types of science and reasoning, and outline their roles in the scientific method.
- Differentiate between hypothesis, prediction and theory.
- Explain how science rejects hypotheses, not proves them.
- Summarize characteristics that distinguish science from non-science.
- Explain confounding variables and the role of controls in addressing them.
- Explain inferential strength and extrapolation, and how these relate to observational and manipulative studies.
- Outline the four requirements for science to lead to knowledge acquisition.
- Demonstrate understanding through a case study on human skin colour evolution.
Definitions Continued
- Biology: The intellectual and practical activity encompassing the systematic study of the structure and behaviour of the natural world through both observation and experimentation.
- Scientific Method: An approach to knowledge acquisition that ensures understanding is based on evidence (data acquired from observation and experimentation).
Two Types of Science
- Descriptive science: Characterizes patterns in the natural world.
- Hypothesis-testing science: Tests causal explanations for existing patterns in the natural world.
Importance of Both Types
- Descriptive science provides the basis for hypothesis-testing (identifying patterns, suggesting explanations).
- Hypothesis-testing science interprets patterns and guides the search for further patterns.
Example: Eutrophication
- Descriptive study: Reveals a pattern (e.g., primary production increasing with potassium concentration).
- Hypothesis: Potassium is a limiting nutrient, increasing its availability leads to increased algal growth.
- Experimental test: Manipulating potassium concentration shows no effect.
- Rejection of hypothesis: Identifying other potential factors that may impact primary production.
The Scientific Method (Diagrammatic Summary)
- Descriptive science + Induction → Biological hypothesis → Deduction → Prediction → Study & Data → Inference → Conclusions (support or reject hypothesis)
Induction
- Specific observations (patterns) are synthesized to create a general statement (conclusion).
- Inductive reasoning can be the source of biological hypotheses, but it is not ideal for testing them.
- If all axioms are true, then the conclusion can still be false.
Deduction in Hypothesis-Testing Science
- Hypothesis: A causal explanation of a pattern.
- Prediction: A statement of what should be observed if the hypothesis is true.
- A prediction only exists within the context of a specific hypothesis and study.
- The scientific method applies deduction to generate predictions and test hypotheses.
Deduction (Syllogism)
- A form of reasoning from one or more general statements (premises) to a logical conclusion.
- If the premises are true, the conclusion must also be true.
- For example: Premise 1: All birds have feathers Premise 2: All robins are birds Conclusion: Therefore, all robins have feathers
Deduction in Hypothesis Testing
- With respect to testing a hypothesis, predictions must follow deductively from the hypothesis.
- Predictions can be formalized as if/then statements. (If hypothesis X is true and a study of type Y is performed, then result Z will be observed.)
What Makes a Scientific Hypothesis
- A scientific hypothesis must be causal and refutable in principle, having possible outcomes inconsistent with it, which means it is falsifiable.
- It cannot be possible to conclusively prove a hypothesis, only falsify. A hypothesis that cannot be falsified is not a scientific hypothesis.
- Example of an unfalsifiable claim: "Life arose from divine creation."
Science Proceeds by Falsifying Hypotheses
- Popper argued that science eliminates hypotheses, not proves them.
- One cannot definitively prove a hypothesis; any observation supporting a hypothesis does not automatically prove it true (it can be an outcome of an alternative cause).
- Disproving a prediction falsifies a hypothesis.
- Example: If the garden is not wet, and you predict that if it rained last night the garden will be wet, then the hypothesis 'It rained last night' is falsified.
A Logical Fallacy: You Can't Prove a Hypothesis
- One cannot prove a hypothesis by observing a supported prediction (it could stem from a different cause).
Observational vs. Manipulative Studies
- Observational studies observe or measure characteristics without altering the system.
- Manipulative studies (experiments) actively change and measure some aspect(s) of a system and compare this to a control.
- Inferential strength is greater in manipulative studies, due to better control of confounding variables.
Confounding Variables
- Confounding variables are other factors that may influence the variable being studied and can create false associations and incorrect conclusions.
- Manipulative studies help reduce confounding variables.
Example: Effect of an Oncolytic Virus
- Biological questions (e.g., Can a tumour-killing virus effectively reduce tumour growth rates in vivo)?
- Procedure or experimental design (e.g., Inject a virus suspension into spontaneous tumour mouse model and track growth)
- Design and implementation of appropriate controls (comparison group to rule out other factors that could affect growth).
All Else is Often Not Equal: Extrapolation
- Studies are often conducted on model systems which are smaller or simpler than the actual system of interest and require extrapolation.
- Extracting inferences from model systems assumes that the models behave similarly.
- The amount of extrapolation required influences the strength of inferences and conclusions.
Common Types of Extrapolation
- Interspecies (e.g., using rat models for human health study).
- From indicators to system properties (e.g., using gene expression as a proxy for biological processes).
- Spatial and temporal scales
- In vitro to in vivo extrapolation
Hypotheses and Predictions
- A hypothesis is a statement about possible causes of a pattern.
- A prediction details the expected outcome of a study if the hypothesis is correct.
- Observed patterns support, but do not prove, a hypothesis
Hypothesis vs. Theory
- A theory is a hypothesis that has withstood numerous attempts at falsification and is therefore an accepted explanation.
Case Study: Skin Colour Evolution in Humans
- A summary of geographic variation in human skin colour.
- Possible hypotheses for the evolutionary causes of these variations are proposed, such as evolutionary selection for reduced UV-induced DNA degradation and increased vitamin D synthesis.
- A case study is presented to explain the evolution of human skin colour.
Statistical Hypothesis Testing
- Determines if a pattern in results is real or due to chance variation.
- Important for assessing the validity of observed patterns.
- Descriptive science often involves statistical hypothesis testing.
- Statistical inference is used to determine the presence of predicted patterns and support/reject hypotheses based on that evidence.
Science vs. Pseudo-science
- Pseudo-science is a study that seeks only to confirm preconceived beliefs, without critically evaluating the evidence.
- Popper called such studies pseudo-science.
Rationality and Skepticism in Scientific Inquiry
- Science relies on reason and evidence-based inferences.
- Scientists constantly question and evaluate hypotheses and evidence.
Required Characteristics for Scientific Inquiry
- Be rational.
- Be skeptical.
- Objectively evaluate hypotheses and evidence.
- Avoid making assumptions or drawing conclusions based on irrelevant or non-testable factors (e.g., supernatural causes).
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Description
Test your understanding of the scientific method and its applications in biology. This quiz covers hypotheses, experimental procedures, and the advantages of manipulative studies over observational studies. Challenge your knowledge of key concepts and definitions relevant to biological research.