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Questions and Answers
What is the primary mechanism of Darwinian evolution?
What is the primary mechanism of Darwinian evolution?
What does the cell theory state about all organisms?
What does the cell theory state about all organisms?
Which statement best represents a key point of modern cell theory?
Which statement best represents a key point of modern cell theory?
What is a consequence of natural selection in relation to species?
What is a consequence of natural selection in relation to species?
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What defines a cell as the smallest self-reproducing unit of life?
What defines a cell as the smallest self-reproducing unit of life?
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Which of the following statements about the activity of an organism is correct?
Which of the following statements about the activity of an organism is correct?
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Which characteristic is NOT part of modern cell theory?
Which characteristic is NOT part of modern cell theory?
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How does cell theory relate to evolution?
How does cell theory relate to evolution?
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Which of the following is NOT one of the basic features shared by all cells?
Which of the following is NOT one of the basic features shared by all cells?
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What is the primary function of ribosomes in cells?
What is the primary function of ribosomes in cells?
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Which unit of measure is used to describe atomic bond lengths?
Which unit of measure is used to describe atomic bond lengths?
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Why is understanding cells important in the context of human health and disease?
Why is understanding cells important in the context of human health and disease?
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Which of the following is NOT a mechanism of evolution?
Which of the following is NOT a mechanism of evolution?
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How many cells approximately are there in the human body?
How many cells approximately are there in the human body?
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What is essential for natural selection to lead to evolution?
What is essential for natural selection to lead to evolution?
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Which concept is considered a unifying principle in biology alongside cell theory?
Which concept is considered a unifying principle in biology alongside cell theory?
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Which statement best describes differential survival and reproduction?
Which statement best describes differential survival and reproduction?
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What is the relationship between macroevolution and microevolution?
What is the relationship between macroevolution and microevolution?
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The structure that separates the interior of a cell from its external environment is known as what?
The structure that separates the interior of a cell from its external environment is known as what?
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How does gene flow contribute to evolution?
How does gene flow contribute to evolution?
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Which of the following is NOT one of the broad categories of evidence supporting Darwin's theory of evolution?
Which of the following is NOT one of the broad categories of evidence supporting Darwin's theory of evolution?
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What does metabolism refer to in the context of cellular functions?
What does metabolism refer to in the context of cellular functions?
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What are traits that can be passed from one generation to the next called?
What are traits that can be passed from one generation to the next called?
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Which term describes the similarity in structure and function in different species due to common ancestry?
Which term describes the similarity in structure and function in different species due to common ancestry?
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What evidence of evolution describes how organisms evolve to adapt to their environments?
What evidence of evolution describes how organisms evolve to adapt to their environments?
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Why are mutations important in the process of evolution?
Why are mutations important in the process of evolution?
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What is an example of natural selection in action?
What is an example of natural selection in action?
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Which of the following correctly reflects Darwin's concept of 'descent with modification'?
Which of the following correctly reflects Darwin's concept of 'descent with modification'?
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Which factor would likely NOT influence evolutionary changes in a population?
Which factor would likely NOT influence evolutionary changes in a population?
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Which aspect of evolution refers to the changes in inherited traits in a population over generations?
Which aspect of evolution refers to the changes in inherited traits in a population over generations?
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What type of homology involves examining genetic sequences shared among different organisms?
What type of homology involves examining genetic sequences shared among different organisms?
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Which provides evidence of evolutionary history through geographical distribution?
Which provides evidence of evolutionary history through geographical distribution?
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What term describes structures that are similar due to independent evolution, not derived from a common ancestor?
What term describes structures that are similar due to independent evolution, not derived from a common ancestor?
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Which of the following is an example of convergent evolution?
Which of the following is an example of convergent evolution?
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What concept explains species being more closely related to other species in the same area than to those further away?
What concept explains species being more closely related to other species in the same area than to those further away?
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The fossil record provides evidence for Darwin's theory by demonstrating:
The fossil record provides evidence for Darwin's theory by demonstrating:
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Which major event in Earth's history greatly affected the distribution of marsupials and placental mammals?
Which major event in Earth's history greatly affected the distribution of marsupials and placental mammals?
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Divergent evolution is primarily the result of:
Divergent evolution is primarily the result of:
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What type of evolution illustrates similar adaptations among unrelated species in response to similar environmental challenges?
What type of evolution illustrates similar adaptations among unrelated species in response to similar environmental challenges?
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Which of the following features is NOT characterized by convergent evolution?
Which of the following features is NOT characterized by convergent evolution?
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What is the significance of stromatolites in the fossil record?
What is the significance of stromatolites in the fossil record?
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How long were prokaryotes the only cellular form of life on Earth?
How long were prokaryotes the only cellular form of life on Earth?
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Which event marked a significant milestone in the evolution of life, occurring after abiogenesis?
Which event marked a significant milestone in the evolution of life, occurring after abiogenesis?
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What was the order of key events leading to the emergence of multicellularity?
What was the order of key events leading to the emergence of multicellularity?
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Which of the following describes the term 'endosymbiogenesis'?
Which of the following describes the term 'endosymbiogenesis'?
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What is a likely characteristic of the first multicellularity formed around 1.8 billion years ago?
What is a likely characteristic of the first multicellularity formed around 1.8 billion years ago?
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Which of the following entities is considered to have emerged independently as multicellular life?
Which of the following entities is considered to have emerged independently as multicellular life?
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What major event in the history of life is characterized by the increase of oxygen in the Earth's atmosphere?
What major event in the history of life is characterized by the increase of oxygen in the Earth's atmosphere?
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Study Notes
Biology 1 - Cells, Molecular Biology and Genetics (Biol 1000)
- Course offered by Dr. Michael Cardinal-Aucoin in Winter 2025
- Course code is Biol 1000
- Focuses on cells, molecular biology, and genetics
Evolution
- Major unifying theories in biology
- Darwinian evolution, including natural selection
- Evidence and examples of evolution
Major Unifying Concepts of Biology
- Theory of Evolution by Natural Selection
- Cell Theory
- Genetics
- Homeostasis
Note about Theories
- Everyday use: theory means a guess, or "untested speculation"
- In science: a broad explanation based on many lines of evidence, aids in the generation of new hypotheses, and has withstood rigorous scientific testing
Two Major Unifying Concepts of Biology
- Theory of Evolution by Natural Selection:
- Characteristics of a population change over time (pattern)
- Individuals with certain heritable traits produce more offspring than those without (mechanism)
- All species are related by descent from a common ancestor and descend from other pre-existing species
- Cell Theory:
- All organisms are made up of cells (pattern)
- All cells come from pre-existing cells (mechanism)
- All single-cell organisms in a population are related to a common ancestor
- All cells in a multi-cellular organism descend from an ancestral cell and all organisms are made up of cells
Modern Cell Theory
- A cell is the smallest self-reproducing unit of life
- Cells make up all living things
- New cells arise from pre-existing cells
- The activity of an organism depends on the total activity of independent cells
- Energy flow (metabolism and biochemistry) occurs within cells
- Cells contain hereditary information in the form of DNA and RNA
- Cells of similar organisms share similar chemical composition
Cells
- All cells share certain properties, but are not identical
- Plant cells (20 x 30 μm)
- Animal cells (20 μm)
- Bacteria (1 x 2 μm)
Different Types of Cells
- Four basic features of all cells:
- Plasma membrane
- Semifluid substance called cytosol
- Genetic material (at some point)
- Ribosomes (to make proteins)
- Plus metabolism (chemical pathways to convert various forms of energy into biochemical work)
Units of Measure
- µm - Micrometer: 1,000,000 micrometers = 1 meter
- Strand of hair ~20-180µm in diameter
- nm - Nanometer: 1,000,000,000 nanometers = 1 meter
- Wavelength of visible light (~400-700nm)
- Å - Angstrom: 10,000,000,000 Angstroms = 1 meter
- Used to measure atom/bond lengths, C-H bond in methane ~1 Angstrom
Introduction to the Cell
- Relative sizes of various biological entities on a logarithmic scale (e.g., atoms, viruses, bacteria, cells, eggs, humans).
Why study cells?
- Cells are the fundamental functional unit of all living things
- Cell theory is a unifying principle in biology
- Understanding cells allows us to understand how organisms function (plants, animals, parasites, fungus, etc)
- Knowledge of cells is critical to understanding human health and disease, as well as disease treatment
Nothing in biology makes sense except in the light of evolution
- Evolution is a unifying theme in biology, alongside cell theory
- Explains many disparate facts
- All living things are the result of evolution
Other Mechanisms that drive Evolution
- Artificial selection
- Sexual selection
- Genetic drift
- Gene flow
Evolution by Natural Selection
- Population differences between individuals
- Mutations, meiosis (sexual reproduction) mixes things up
- Heritable traits
- Traits can be passed from one generation to the next
- Differential survival and reproduction
- Some individuals leave more offspring than others
- Then evolution occurs over time
Evolution by Natural Selection (alternative phrasing)
- If a population has differences, traits that are heritable, and individuals leave more offspring than others, then evolution will occur over time.
It is not the strongest...
- Adaptation to change is crucial for survival
How Natural Selection Works
- Environmental resources are limited
- Organisms compete for space, food, mates, etc
- Members of a population differ in their characteristics
- Some characteristics provide an advantage in competition
- Individuals with these traits live longer and produce more offspring.
Evolution by natural selection
- If a population has differences between individuals, those traits are heritable and the result is differential survival and reproduction, then evolution occurs over time. This is a restatement that's a bit more concise.
Natural selection acts "sees"
- Genotype: The genetic makeup of an organism
- Phenotype: Observable characteristics of an organism
Evolution = Genotype Phenotype Environment
- Explains how genotype, phenotype, and environment interact in evolution.
Macroevolution = Microevolution x Time
- Cumulative effects of small changes over millions of years lead to major evolutionary changes
The Vastness of Evolutionary Time
- Earth is 4,600,000,000 years old
- Multiple timescales (human generations, mouse generations, fly generations, bacteria generations) are presented in relation to Earth's age.
Macroevolution=Microevolution x time
- Over time, phenotypic differences accumulate producing major transitions in evolution
- Even complex organisms evolve from single cells over millions of years
Evidence for Evolution by Natural Selection
- Lots of examples of evidence demonstrating evolutionary change are provided, but the specific details are not summarized here, primarily due to the significant amount of image data displayed.
Evidence for Darwin's Theory (Homology)
- Homology: Similarity resulting from a common ancestry
- Anatomical, Embryological/developmental, Genetic/Molecular examples including vestigial traits
Homology: Vestigial Genetic/Molecular
- Icefish example: a species of fish that lives in frigid Antarctic waters and lacks hemoglobin, yet retains part of the hemoglobin gene. This is a vestigial characteristic.
- Example of different types of hemoglobin genes from various species on phylogenetic tree that also shows evolutionary relationships.
- Complete loss of the 24th pair of chromosomes in humans from great ape ancestry is a possible example of this concept
Convergent Evolution
- When characters are similar but are not derived from a common ancestor.
- Analogous characters develop due to adaptation to similar environments in unrelated groups
Biogeography
- Species distributions can be explained by evolution
- Species tend to be more closely related to those in the same area
- Common ancestors adapting to nearby habitats
- Pangea example of continental drift leading to isolation and the evolution of different species, including marsupials in Australia
Fossil Record
- Oldest fossils from 4 billion years ago
- Cyanobacteria (blue-green algae) and Precambrian fossils
- Oldest cyanobacteria-like fossils are 3.5 billion years ago
- Cyanobacteria are larger than most bacteria - secrete a thick cell wall
- Often form layered structures (stromatolites) or round ones (oncolites)
Fossil record examples of multicellularity
- First single-celled eukaryotes from 1.8 billion years ago (Parfreya et al. 2011)
- Prokaryotes were the only cells for over 2 billion years
- True multicellularity appeared around 1.8 to 1.5 billion years ago
- Many independent origins of life forms (plants, animals, fungi, red algae, brown algae, myxomycetes etc)
How is evolution relevant to cell biology?
- Explain how cells evolved
- Detail the structure/function of cells
- Explain how cells adapt to different environments/circumstances.
Main Events in the Evolution of Cells
- Abiogenesis
- Protocells
- RNA world
- Prokaryotes
- Endosymbiosis
- Eukaryotes
- Multicellularity
Abiogenesis
- Prebiotic synthesis: formation of life's molecules under prebiotic conditions
- No fossil records, but laboratory experiments can replicate early Earth conditions.
- Living things are composed of carbohydrates, lipids, proteins, and nucleic acids
Protocells
- Formation of lipids (phospholipids) in aqueous environments (water) result in the instant creation of micelles and liposomes
RNA world
- RNA's properties of storing information (similar to DNA) and acting as enzymes (similar to protein)
- Current scientific evidence (experiments) supports the idea that RNA came before DNA in early life forms.
Prokaryotes
- Small, simple cells without internal compartments
- Evolved most of the biochemistry present in all life forms
- DNA replication, the genetic code, protein synthesis via transcription/translation, photosynthesis, anaerobic/aerobic respiration
- Evolved into eubacteria and archaea
Endosymbiosis
- Ancestral organelles (e.g., mitochondria, chloroplasts) were free-living prokaryotes
- These prokaryotes were engulfed by larger cells and became incorporated into the host cells
Eukaryotes
- Compartmentalization (membrane-bound organelles)
- Cellular trafficking (endomembrane system)
- Larger cells, true multicellularity
- Mitosis/meiosis (increased genetic diversity for natural selection)
Multicellularity
- First came about 2.7 billion years ago and took off around 1 billion years ago
- Key advantage is size
- Competition for resources (food)
- Defense against predators
- Division of labor
Eukaryotes
- The eukaryotic cell is evolution's major achievement: multicellular life is merely a crude elaboration. (Simon Conway Morris)
Next time: Biological Macromolecules
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Description
Test your understanding of key concepts in biology, specifically focusing on Darwinian evolution and cell theory. This quiz covers fundamental questions about the mechanisms of evolution, characteristics of cells, and their relevance in health and disease.