Biochemistry Basics Quiz
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Questions and Answers

What is the primary function of lipids in biological membranes?

  • To catalyze biological reactions
  • To act as energy storage molecules
  • To form a barrier that regulates the passage of molecules (correct)
  • To provide structural support and rigidity
  • Which of the following is NOT a feature of amino acids?

  • They can form polymers through dehydration reactions.
  • They are chiral molecules with a stereocenter.
  • The R group determines the specific properties of each amino acid.
  • They are all water-soluble due to the presence of an amino group. (correct)
  • They have a central carbon atom that is bonded to four different functional groups.
  • Which of the following interactions is NOT involved in the binding of naproxen to its protein target?

  • Hydrogen bonding
  • Van der Waals forces
  • Ionic interactions
  • Covalent bonding (correct)
  • What is a key difference between DNA and RNA?

    <p>All of the above. (D)</p> Signup and view all the answers

    Which of the following correctly describes the role of the R group in amino acids?

    <p>All of the above. (D)</p> Signup and view all the answers

    What are the four main classes of biomolecules?

    <p>Carbohydrates, lipids, proteins, and nucleic acids. (C)</p> Signup and view all the answers

    What type of isomerism is present in carbohydrates, specifically when referring to diastereomers?

    <p>Diastereomers (D)</p> Signup and view all the answers

    Which of the following is a key feature of steroids?

    <p>They have a characteristic four-ring structure. (D)</p> Signup and view all the answers

    Which of the following statements accurately describes enantiomers?

    <p>Enantiomers are non-superimposable mirror images of each other. (D)</p> Signup and view all the answers

    What is the key characteristic that distinguishes chiral molecules from achiral molecules?

    <p>Chiral molecules cannot be superimposed on their mirror images, while achiral molecules can. (C)</p> Signup and view all the answers

    Which of the following terms is used to describe molecules that are different across a plane of symmetry but have the same parts?

    <p>Diastereomers (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the relationship between enantiomers and diastereomers?

    <p>Enantiomers and diastereomers are distinct types of stereoisomers. (A)</p> Signup and view all the answers

    Why are sp3 hybridized carbons with two identical substituents considered achiral and not stereocenters?

    <p>Because they have a plane of symmetry, making them superimposable on their mirror image. (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the term 'stereocenter'?

    <p>An atom that has four different substituents attached to it. (A)</p> Signup and view all the answers

    What is the significance of the 'R' and 'S' designations in stereochemistry?

    <p>They represent the absolute configuration of a chiral center. (C)</p> Signup and view all the answers

    Which of the following describes how the term DIASTEREOMERS relates to the Greek word roots?

    <p>Diastereomers are molecules with the same parts that are different across a plane of symmetry. (A)</p> Signup and view all the answers

    What is the key factor that distinguishes enantiomers?

    <p>Interactions with chiral molecules or light (A)</p> Signup and view all the answers

    What is a racemic mixture?

    <p>A mixture of two enantiomers in a 50/50 ratio (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of diastereomers?

    <p>They are mirror images of each other (C)</p> Signup and view all the answers

    Which of the following molecules can exist as diastereomers?

    <p>A molecule with two or more sp3 chiral stereocenters (C)</p> Signup and view all the answers

    What is the relationship between enantiomers and proteins?

    <p>Proteins can distinguish between enantiomers (C)</p> Signup and view all the answers

    How can you distinguish between enantiomers?

    <p>By observing their reactions with chiral molecules or light (D)</p> Signup and view all the answers

    What is the significance of the (R) and (S) designations for enantiomers?

    <p>They indicate the absolute configuration at the stereocenter (B)</p> Signup and view all the answers

    What is the approximate age of the technology that allows for the production of single enantiomers of drugs?

    <p>20 years (A)</p> Signup and view all the answers

    A molecule with two stereocenters will have how many sets of enantiomers?

    <p>Two (B)</p> Signup and view all the answers

    Which of the following statements about enantiomers is TRUE?

    <p>Enantiomers are always mirror images of each other. (C)</p> Signup and view all the answers

    What is the requirement for an sp3 tetrahedral carbon to be a stereocenter?

    <p>It must have four different substituents. (A)</p> Signup and view all the answers

    What is the definition of a racemic mixture?

    <p>A mixture of two enantiomers in equal amounts. (B)</p> Signup and view all the answers

    What is the difference between an enantiomer and a diastereomer?

    <p>Enantiomers are mirror images of each other, while diastereomers are not. (B)</p> Signup and view all the answers

    What is the primary difference between triglycerides and phospholipids?

    <p>Phospholipids have a polar head group, while triglycerides do not. (B)</p> Signup and view all the answers

    What makes phospholipids ideal for forming cell membranes?

    <p>Their amphipathic nature, allowing them to form a bilayer structure with hydrophilic heads facing the watery environment and hydrophobic tails forming the core of the membrane. (D)</p> Signup and view all the answers

    What is the role of esterification in the formation of triglycerides?

    <p>Esterification links three fatty acid molecules to a glycerol molecule, forming a triglyceride. (D)</p> Signup and view all the answers

    Which of the following statements correctly describes a key difference between the structure of triglycerides and phospholipids?

    <p>Phospholipids contain a phosphate group, while triglycerides do not. (B)</p> Signup and view all the answers

    What is the primary function of triglycerides in biological systems?

    <p>To store energy for long-term use. (B)</p> Signup and view all the answers

    What type of interaction is responsible for the formation of a lipid bilayer?

    <p>Hydrophobic interactions between the non-polar tails of phospholipids. (B)</p> Signup and view all the answers

    What property of phospholipids allows them to form a bilayer membrane?

    <p>Their amphipathic nature, possessing both polar and non-polar regions. (D)</p> Signup and view all the answers

    How does the structure of a phospholipid contribute to the formation of cell membranes?

    <p>The amphipathic nature of phospholipids allows them to form a bilayer structure with hydrophobic tails facing inwards and hydrophilic heads facing outwards. (D)</p> Signup and view all the answers

    What is one of the primary functions of carbohydrates in the body?

    <p>Serve as an energy source (B)</p> Signup and view all the answers

    Which statement correctly describes nucleotides?

    <p>Nucleotides consist of a nucleobase, a carbohydrate, and a phosphate group. (B)</p> Signup and view all the answers

    What are the main components of a nucleotide?

    <p>Nucleobase, ribose carbohydrate, and phosphate (D)</p> Signup and view all the answers

    Which carbohydrate is involved in the medium-term energy storage in the body?

    <p>Starch (D)</p> Signup and view all the answers

    What distinguishes ribose from deoxyribose in their structures?

    <p>Deoxyribose has one less oxygen atom compared to ribose. (A)</p> Signup and view all the answers

    What type of molecule is formed when nucleotides bond together?

    <p>Polynucleotide (C)</p> Signup and view all the answers

    In what forms should ribose and deoxyribose be recognized?

    <p>Both cyclized and non-cyclized forms (A)</p> Signup and view all the answers

    Which function does ATP serve beyond being part of nucleic acids?

    <p>Energy transfer currency (C)</p> Signup and view all the answers

    Flashcards

    Stereochemistry

    The study of spatial arrangements of atoms in molecules.

    Conformational Isomer

    Isomers that differ in the rotation around single bonds.

    Chirality

    The property of a molecule having non-superimposable mirror images.

    Enantiomers

    A pair of stereoisomers that are mirror images of each other.

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    Racemic Mixture

    A mixture that contains equal amounts of both enantiomers of a chiral molecule.

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    sp3 stereocenters

    Carbon atoms with four different substituents bonded, creating chirality.

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    Achiral

    A property of molecules where the mirror image can be superimposed on the original.

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    Stereocenter

    A carbon atom bonded to four different substituents, creating stereoisomerism.

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    R and S configurations

    Designations for the two enantiomers based on their spatial arrangements.

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    Stereoisomers

    Compounds with the same molecular formula but different spatial arrangements of atoms.

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    Diastereomers

    Stereoisomers that are not mirror images and differ across at least one plane of symmetry.

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    Chiral Molecules

    Molecules that cannot be superimposed on their mirror images.

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    Chiral Light Interaction

    How chiral molecules interact differently with enantiomers.

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    Physical Properties of Diastereomers

    Diastereomers have different physical properties compared to each other.

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    Biomolecules

    Four major classes of molecules essential for life: carbohydrates, lipids, proteins, nucleic acids.

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    Lipid Bilayers

    Double layers of lipids that form cell membranes, essential for compartmentalization in cells.

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    Amino Acids

    Building blocks of proteins, characterized by a central carbon, amino group, carboxyl group, and R group.

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    Nucleotides

    Basic unit of nucleic acids, composed of a sugar, phosphate group, and nitrogenous base.

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    Carbohydrates

    Molecules consisting of sugars, existing as monosaccharides, disaccharides, or polysaccharides.

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    Steroid Lipids

    A class of lipids with a structure of four fused carbon rings, important in cell membranes and signaling.

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    DNA vs. RNA

    DNA is double-stranded and contains deoxyribose; RNA is single-stranded and contains ribose.

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    Triglycerides

    Lipids made of 3 fatty acids bonded to glycerol for energy storage.

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    Esterification

    The process of forming esters from glycerol and fatty acids.

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    Phospholipids

    Lipids similar to triglycerides but contain a phosphate group, creating a polar head.

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    Hydrophobic Tails

    The non-polar carbon chains of phospholipids that repel water.

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    Charged Polar Group

    Part of phospholipids that interacts well with water; crucial for membrane properties.

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    Intermolecular Forces

    Forces that cause phospholipids to organize in water, forming structures like bilayers.

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    Biological Membrane Function

    Phospholipid bilayers create flexible compartments in watery environments for cells.

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    Energy Source

    The primary function of carbohydrates to provide energy for cellular processes, e.g., glucose.

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    Polysaccharides

    Polymers made up of multiple glucose units used for medium-term energy storage.

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    Nucleic Acids

    Biopolymers, namely DNA and RNA, made of nucleotide monomers.

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    Ribose

    A five-carbon sugar found in RNA and as part of nucleotides.

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    Deoxyribose

    A sugar similar to ribose but missing an oxygen atom, found in DNA.

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    Nucleobases

    The building blocks of nucleotides, there are five important types.

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    Study Notes

    Lecture Information

    • Course: PHAR 7813 Principles of Drug Action I
    • Lecture: 5
    • Topic: Understanding Drugs on the Molecular Level: Stereochemistry and Molecular Introduction to Biomolecules
    • Date: January 31st, 2023
    • Instructor: Anthony W. G. Burgett, Ph.D.

    Learning Objectives: Stereochemistry

    • Define stereochemistry, isomer, conformational isomer, substituents, and stereoisomers.
    • Describe conformational isomers and their limitations in drug molecules.
    • Identify sp² hybridized functional groups that can have multiple stereoisomers based on substituents.
    • Identify requirements for an sp³ tetrahedral carbon to be a stereocenter.
    • Define chirality, asymmetry, stereochemical configuration, enantiomers, and diastereomers.
    • Identify possible stereochemical configurations around an sp³ stereocenter and name them.
    • Explain why enantiomers have identical physical properties but different drug properties.
    • Understand how a molecule with two stereocenters has two sets of enantiomers that are diastereomers to each other.
    • Define and recognize a racemic mixture and its existence in a molecule based on its structure.

    Learning Objectives: Biomolecules

    • List and identify the four major classes of biomolecules based on their structure.
    • Define the lipid class of biomolecules.
    • Describe how lipids organize into bilayers and identify lipid classes.
    • Identify steroids, fatty acid lipids, triglycerides, and phospholipids based on their structures.
    • Define and recognize amino acids, peptides, and proteins.
    • Identify the four parts of an amino acid.
    • Explain why proteins can be considered to have stereochemistry.
    • Define and recognize carbohydrates in open form, closed forms, 3D drawings, and polymeric forms (e.g., glucose, ribose).
    • Recognize monosaccharides, disaccharides, and polysaccharides and their stereoisomer forms.
    • Identify the three components that make up nucleotides and how they polymerize into nucleic acids (DNA and RNA).
    • Recognize that nucleotides have biological activities besides forming DNA/RNA.
    • Identify ribose and deoxyribose in open and closed forms and the 5 nucleobases (e.g., adenine, cytosine, thymine, uracil, guanine) related to nucleotides.
    • Explain the molecular structural differences between DNA and RNA.

    Understanding Drugs on the Molecular Level

    • Stereochemistry greatly influences drug molecule form and function (illustrated with naproxen).
    • The precise arrangement of atoms (stereochemistry) is vital for a drug to bind to its target protein.
    • Different stereochemical configurations of a compound can lead to drastically different interactions with proteins, influencing drug effectiveness.

    Organic Chemistry Review of Stereochemistry

    • Isomers are different compounds with the same molecular formula.
    • Stereoisomers have the same connectivity but different 3D arrangements.
    • Constitutional isomers have different bonding patterns.
    • Configurational isomers cannot be converted by rotating around single bonds (e.g., sp² carbons, alkane groups).
    • Conformational isomers can be converted by rotating around single bonds.
    • Enantiomers are nonsuperimposable mirror images.
    • Diastereomers are stereoisomers that are not mirror images.
    • Geometric Isomers (sp²) have no stereocenters; Optical Isomers (sp³) have stereocenters.

    Understanding sp³ Chiral Stereocenters

    • A molecule with an sp³ hybridized carbon atom with four different substituents is chiral.
    • The four different configurations create two non-superimposable mirror images called enantiomers (denoted as R or S).

    Diastereomers

    • Diastereomers differ in configuration at two or more stereocenters.
    • They have different properties because they are not mirror images and therefore are not enantiomers.

    Racemic Mixture

    • A racemic mixture contains equal amounts of both enantiomers of a chiral compound.
    • The mixture shows squiggly lines between the chiral center and its substituents.
    • Historically, this meant drug manufacturing did not focus on separate pure enantiomers but now there is increased focus on single enantiomer preparation due to vastly different therapeutic effects.

    Molecular Introduction to Biomolecules

    • Major biological molecules include nucleic acids (DNA and RNA), proteins, carbohydrates, and lipids.
    • Lipids are categorized by their features and poor aqueous solubility.
    • Main types of molecules of Lipids are: triglycerides, fatty acids, phospholipids, and steroids.
    • Nucleic acids consist of nucleotides.
    • Proteins are polymers of amino acids.
    • Carbohydrates can be monosaccharides, disaccharides, or polysaccharides.

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    Description

    Test your knowledge on fundamental concepts in biochemistry, including the functions of lipids, amino acids, biomolecule classes, and the differences between DNA and RNA. This quiz covers essential topics every student in the field should know, such as isomerism and molecular interactions. Challenge yourself and see how well you understand these key biochemical principles!

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