9 Questions
What is the definition of bioavailability?
The fraction of the dose which reaches the systemic circulation as unchanged drug.
What does bioavailability depend on?
All of the above
What does bioavailability equal to based on the given formula?
Fraction absorbed * Escaping first pass clearance
What is first pass clearance also known as?
First pass metabolism or first pass extraction
Which factor determines the fraction of the dose that reaches the systemic circulation as unchanged drug?
Fraction absorbed from the gut
What is the aim of bioavailability studies?
All of the above
What does first pass clearance refer to in pharmacokinetics?
Extent to which the drug is removed by the liver during its first passage
What is the expression for the bioavailability as a product of two fractions?
F = fg * fH
What is the main purpose of conducting bioavailability studies?
To determine safety and efficacy of a product
Test your knowledge about bioavailability and bioequivalence, including concepts such as absorption, first pass clearance, and first pass metabolism.
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