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Questions and Answers
Why is determining bioavailability important for calculating drug dosages for non-intravenous routes of administration?
Why is determining bioavailability important for calculating drug dosages for non-intravenous routes of administration?
- To adjust for the incomplete absorption of the drug (correct)
- To prevent drug resistance
- To reduce the cost of drug development
- To ensure the drugs reach the targeted tissues
What is the bioavailability of a drug if 85mg is absorbed unchanged out of an orally administered 100mg?
What is the bioavailability of a drug if 85mg is absorbed unchanged out of an orally administered 100mg?
- 0.80 or 80%
- 0.90 or 90%
- 0.85 or 85%
- 0.75 or 75% (correct)
If 60mg of a drug is absorbed unchanged following intravenous administration, what is the bioavailability?
If 60mg of a drug is absorbed unchanged following intravenous administration, what is the bioavailability?
- 0.40 or 40%
- 0.35 or 35%
- 0.60 or 60%
- 1.00 or 100% (correct)
Which type of amines can undergo oxidative N-dealkylation and N-oxide formation?
Which type of amines can undergo oxidative N-dealkylation and N-oxide formation?
What is the result of oxidative deamination of primary aliphatic amines through the carbinolamine pathway?
What is the result of oxidative deamination of primary aliphatic amines through the carbinolamine pathway?
What type of amines generate the corresponding N-hydroxylamine metabolites upon N-oxidation?
What type of amines generate the corresponding N-hydroxylamine metabolites upon N-oxidation?
Which type of amines is susceptible to further oxidation to yield other N-oxygenated products like nitroso and the nitro derivatives?
Which type of amines is susceptible to further oxidation to yield other N-oxygenated products like nitroso and the nitro derivatives?
Which enzyme catalyzes the conjugation of substrates with GSH?
Which enzyme catalyzes the conjugation of substrates with GSH?
What is the major structural requirement for substrates susceptible to GSH conjugation?
What is the major structural requirement for substrates susceptible to GSH conjugation?
Which functional group is the target for acetylation in the metabolic pathway discussed?
Which functional group is the target for acetylation in the metabolic pathway discussed?
Which metabolic pathway aims to terminate the biological activity and detoxify drugs and xenobiotics?
Which metabolic pathway aims to terminate the biological activity and detoxify drugs and xenobiotics?
What is the main objective of phase II conjugation reactions in drug metabolism?
What is the main objective of phase II conjugation reactions in drug metabolism?
What is the role of GSH in drug metabolism?
What is the role of GSH in drug metabolism?
How do methylation and acetylation phase II reactions primarily influence drug metabolism?
How do methylation and acetylation phase II reactions primarily influence drug metabolism?
What can happen to glucuronide and sulfate conjugates in drug metabolism?
What can happen to glucuronide and sulfate conjugates in drug metabolism?
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