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Questions and Answers
Why is determining bioavailability important for calculating drug dosages for non-intravenous routes of administration?
Why is determining bioavailability important for calculating drug dosages for non-intravenous routes of administration?
What is the bioavailability of a drug if 85mg is absorbed unchanged out of an orally administered 100mg?
What is the bioavailability of a drug if 85mg is absorbed unchanged out of an orally administered 100mg?
If 60mg of a drug is absorbed unchanged following intravenous administration, what is the bioavailability?
If 60mg of a drug is absorbed unchanged following intravenous administration, what is the bioavailability?
Which type of amines can undergo oxidative N-dealkylation and N-oxide formation?
Which type of amines can undergo oxidative N-dealkylation and N-oxide formation?
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What is the result of oxidative deamination of primary aliphatic amines through the carbinolamine pathway?
What is the result of oxidative deamination of primary aliphatic amines through the carbinolamine pathway?
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What type of amines generate the corresponding N-hydroxylamine metabolites upon N-oxidation?
What type of amines generate the corresponding N-hydroxylamine metabolites upon N-oxidation?
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Which type of amines is susceptible to further oxidation to yield other N-oxygenated products like nitroso and the nitro derivatives?
Which type of amines is susceptible to further oxidation to yield other N-oxygenated products like nitroso and the nitro derivatives?
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Which enzyme catalyzes the conjugation of substrates with GSH?
Which enzyme catalyzes the conjugation of substrates with GSH?
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What is the major structural requirement for substrates susceptible to GSH conjugation?
What is the major structural requirement for substrates susceptible to GSH conjugation?
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Which functional group is the target for acetylation in the metabolic pathway discussed?
Which functional group is the target for acetylation in the metabolic pathway discussed?
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Which metabolic pathway aims to terminate the biological activity and detoxify drugs and xenobiotics?
Which metabolic pathway aims to terminate the biological activity and detoxify drugs and xenobiotics?
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What is the main objective of phase II conjugation reactions in drug metabolism?
What is the main objective of phase II conjugation reactions in drug metabolism?
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What is the role of GSH in drug metabolism?
What is the role of GSH in drug metabolism?
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How do methylation and acetylation phase II reactions primarily influence drug metabolism?
How do methylation and acetylation phase II reactions primarily influence drug metabolism?
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What can happen to glucuronide and sulfate conjugates in drug metabolism?
What can happen to glucuronide and sulfate conjugates in drug metabolism?
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