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Biliary Excretion and Anthracycline Drugs Quiz

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Biliary Excretion and Anthracycline Drugs Quiz

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Questions and Answers

What is the major route of elimination for anthracycline drugs?

Biliary excretion (correct)

Sweat excretion

Renal excretion

Fecal excretion

What is a visible side effect related to the dark red color of anthracycline drugs?

Yellow discoloration of urine

Magenta discoloration of hair

Red discoloration of urine (correct)

Bluish discoloration of skin

What is the most serious adverse reaction associated with anthracycline drugs?

Temporary hair loss

Digestive issues

Reversible skin discoloration

Dose-dependent cardiotoxicity (correct)

What is the proposed mechanism behind anthracycline-induced cardiotoxicity?

Increased lipid peroxidation Signup and view all the answers

What intervention has shown some success in protecting against doxorubicin-induced cardiotoxicity?

Administering dexrazoxane, an iron chelator Signup and view all the answers

Which phase of the cell cycle does bleomycin cause cells to accumulate in?

G2 phase Signup and view all the answers

What is the main cytotoxic effect of alkylating agents like cyclophosphamide and ifosfamide?

Alkylation of DNA Signup and view all the answers

Which tissue has a low level of the bleomycin-inactivating enzyme, leading to toxicity?

Lung Signup and view all the answers

What is the main cause of pulmonary toxicity associated with bleomycin?

Fibrosis progression Signup and view all the answers

How do alkylating agents impact different types of cells?

They bind covalently to nucleophilic groups on various cell constituents Signup and view all the answers

What is the primary mode of excretion for bleomycin?

Unchanged in urine Signup and view all the answers

How do superoxide and hydroxyl radicals affect DNA in the presence of liberated electrons?

Induce strand breakage Signup and view all the answers