12 Questions
What is the major route of elimination for anthracycline drugs?
Biliary excretion
What is a visible side effect related to the dark red color of anthracycline drugs?
Red discoloration of urine
What is the most serious adverse reaction associated with anthracycline drugs?
Dose-dependent cardiotoxicity
What is the proposed mechanism behind anthracycline-induced cardiotoxicity?
Increased lipid peroxidation
What intervention has shown some success in protecting against doxorubicin-induced cardiotoxicity?
Administering dexrazoxane, an iron chelator
Which phase of the cell cycle does bleomycin cause cells to accumulate in?
G2 phase
What is the main cytotoxic effect of alkylating agents like cyclophosphamide and ifosfamide?
Alkylation of DNA
Which tissue has a low level of the bleomycin-inactivating enzyme, leading to toxicity?
Lung
What is the main cause of pulmonary toxicity associated with bleomycin?
Fibrosis progression
How do alkylating agents impact different types of cells?
They bind covalently to nucleophilic groups on various cell constituents
What is the primary mode of excretion for bleomycin?
Unchanged in urine
How do superoxide and hydroxyl radicals affect DNA in the presence of liberated electrons?
Induce strand breakage
Test your knowledge on biliary excretion as the major route of elimination and the adverse effects of anthracycline drugs, such as visible veins, red discoloration of urine, and irreversible cardiotoxicity. Learn about how cardiotoxicity is linked to the generation of free radicals and lipid peroxidation.
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