Benzodiazepines

Which benzodiazepine is considered to be the longest acting?

What is a potential interaction that can lead to decreased benzodiazepine metabolism?

Which action is NOT associated with benzodiazepines?

Which benzodiazepine is classified as short-acting?

What is a potential consequence of combining benzodiazepines with grapefruit juice?

Which action is NOT typically associated with benzodiazepines?

Which benzodiazepine is classified as a short-acting medication?

What is a potential consequence of combining benzodiazepines with grapefruit juice?

Which action is typically associated with benzodiazepines?

Diazepam is recognized as the longest-acting benzodiazepine, offering extended effects compared to others in the class.
Certain medications, such as some antifungal agents (e.g., ketoconazole), can inhibit enzyme activity leading to decreased metabolism of benzodiazepines, potentially increasing their effects and duration in the body.

Benzodiazepines are typically associated with actions such as anxiolysis (anxiety reduction), sedation, muscle relaxation, and anticonvulsant effects.
Actions NOT typically associated with benzodiazepines include significant stimulation or increased alertness.

Commonly classified as short-acting benzodiazepines include alprazolam, which has a rapid onset and shorter duration of action.
Another consequence of combining benzodiazepines with grapefruit juice is the potential for increased drug levels in the bloodstream, which may enhance sedation and side effects due to grapefruit's effect on metabolic enzymes.