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What is the trade name of Triazolam?
What is the trade name of Triazolam?
What is the classification of Triazolam?
What is the classification of Triazolam?
What is the primary indication for Triazolam?
What is the primary indication for Triazolam?
Insomnia
What is the action of Triazolam?
What is the action of Triazolam?
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What are the pharmacokinetics of Triazolam?
What are the pharmacokinetics of Triazolam?
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What is the time/action profile for Triazolam when taken orally?
What is the time/action profile for Triazolam when taken orally?
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Which of the following are contraindications for Triazolam? (Select all that apply)
Which of the following are contraindications for Triazolam? (Select all that apply)
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What are some adverse effects of Triazolam? (Select all that apply)
What are some adverse effects of Triazolam? (Select all that apply)
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What is the recommended dose for Triazolam?
What is the recommended dose for Triazolam?
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Match the following drugs to their interaction with Triazolam:
Match the following drugs to their interaction with Triazolam:
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Study Notes
Triazolam Overview
- Trade name: Halcion
- Therapeutic classification: Sedative/hypnotics
- Pharmacologic classification: Benzodiazepines
Indications and Usage
- Primarily prescribed for the treatment of insomnia.
Mechanism of Action
- Functions as a benzodiazepine.
- Acts as a positive allosteric modulator at the GABAA receptor.
- Increases the duration of channel opening in response to GABA, leading to chloride ion influx and hyperpolarization of neurons.
Pharmacokinetics
- Well absorbed with widespread distribution in the body.
- 89% protein-binding capacity.
- Metabolized by the liver.
- Half-life ranges from 1.06 to 5.4 hours.
Time/Action Profile
- Oral administration:
- Onset of action: 15-30 minutes.
- Peak effect: 6-8 hours.
Contraindications
- Low serum albumin levels.
- History of psychotic disorders.
- Suicidal ideation.
- Alcohol intoxication or substance abuse.
- Depression and myasthenia gravis.
- Asthma and liver dysfunction.
- Sleep apnea and pregnancy.
- Breastfeeding individuals.
- Chronic obstructive pulmonary disease (COPD).
- Complex sleep behaviors (e.g., sleep-driving).
Adverse Effects
- Central nervous system (CNS) depression.
- Anterograde amnesia.
- Incidents of sleep driving.
- Paradoxical reactions, including insomnia and heightened anxiety.
- Respiratory depression risks.
- Potential for abuse.
- Use during pregnancy and lactation can be harmful as it may cross the placenta and enter breast milk.
Dosage Information
- Typical dosage range: 0.125 to 0.25 mg.
Drug Interactions
- Notable interactions with:
- Itraconazole and ketoconazole (antifungals).
- Nefazodone (antidepressant).
- Indinavir, nelfinavir, ritonavir, saquinavir, lopinavir (antiviral agents).
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Description
This quiz features flashcards focused on Triazolam, a sedative/hypnotic medication. It covers its trade name, classification, indications, and actions at the receptor level. Ideal for students in pharmacology or medicine seeking to enhance their understanding of this drug.
