Questions and Answers
What is the trade name of Triazolam?
What is the classification of Triazolam?
What is the primary indication for Triazolam?
Insomnia
What is the action of Triazolam?
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What are the pharmacokinetics of Triazolam?
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What is the time/action profile for Triazolam when taken orally?
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Which of the following are contraindications for Triazolam? (Select all that apply)
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What are some adverse effects of Triazolam? (Select all that apply)
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What is the recommended dose for Triazolam?
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Match the following drugs to their interaction with Triazolam:
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Study Notes
Triazolam Overview
- Trade name: Halcion
- Therapeutic classification: Sedative/hypnotics
- Pharmacologic classification: Benzodiazepines
Indications and Usage
- Primarily prescribed for the treatment of insomnia.
Mechanism of Action
- Functions as a benzodiazepine.
- Acts as a positive allosteric modulator at the GABAA receptor.
- Increases the duration of channel opening in response to GABA, leading to chloride ion influx and hyperpolarization of neurons.
Pharmacokinetics
- Well absorbed with widespread distribution in the body.
- 89% protein-binding capacity.
- Metabolized by the liver.
- Half-life ranges from 1.06 to 5.4 hours.
Time/Action Profile
- Oral administration:
- Onset of action: 15-30 minutes.
- Peak effect: 6-8 hours.
Contraindications
- Low serum albumin levels.
- History of psychotic disorders.
- Suicidal ideation.
- Alcohol intoxication or substance abuse.
- Depression and myasthenia gravis.
- Asthma and liver dysfunction.
- Sleep apnea and pregnancy.
- Breastfeeding individuals.
- Chronic obstructive pulmonary disease (COPD).
- Complex sleep behaviors (e.g., sleep-driving).
Adverse Effects
- Central nervous system (CNS) depression.
- Anterograde amnesia.
- Incidents of sleep driving.
- Paradoxical reactions, including insomnia and heightened anxiety.
- Respiratory depression risks.
- Potential for abuse.
- Use during pregnancy and lactation can be harmful as it may cross the placenta and enter breast milk.
Dosage Information
- Typical dosage range: 0.125 to 0.25 mg.
Drug Interactions
- Notable interactions with:
- Itraconazole and ketoconazole (antifungals).
- Nefazodone (antidepressant).
- Indinavir, nelfinavir, ritonavir, saquinavir, lopinavir (antiviral agents).
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Description
This quiz features flashcards focused on Triazolam, a sedative/hypnotic medication. It covers its trade name, classification, indications, and actions at the receptor level. Ideal for students in pharmacology or medicine seeking to enhance their understanding of this drug.
