Triazolam Drug Card Flashcards

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Questions and Answers

What is the trade name of Triazolam?

  • Lorazepam
  • Halcion (correct)
  • Zolpidem
  • Ambien

What is the classification of Triazolam?

  • Antipsychotic
  • Antidepressant
  • Stimulant
  • Sedative/Hypnotics (correct)

What is the primary indication for Triazolam?

Insomnia

What is the action of Triazolam?

<p>Benzodiazepine; Positive allosteric modulator at GABAA receptor.</p> Signup and view all the answers

What are the pharmacokinetics of Triazolam?

<p>Well absorbed, widely distributed, 89% protein binding, metabolized by liver, half-life: 1.5-5.4 hr.</p> Signup and view all the answers

What is the time/action profile for Triazolam when taken orally?

<p>Onset: 15-30 mins; Peak: 6-8 hrs (C)</p> Signup and view all the answers

Which of the following are contraindications for Triazolam? (Select all that apply)

<p>Pregnancy (B), Myasthenia gravis (C), Alcohol intoxication (D)</p> Signup and view all the answers

What are some adverse effects of Triazolam? (Select all that apply)

<p>Anterograde amnesia (A), Sleep driving (B), CNS depression (C)</p> Signup and view all the answers

What is the recommended dose for Triazolam?

<p>0.125-0.25 mg</p> Signup and view all the answers

Match the following drugs to their interaction with Triazolam:

<p>Itraconazole = Drug interaction Ketoconazole = Drug interaction Nefazodone = Drug interaction Indinavir = Drug interaction</p> Signup and view all the answers

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Study Notes

Triazolam Overview

  • Trade name: Halcion
  • Therapeutic classification: Sedative/hypnotics
  • Pharmacologic classification: Benzodiazepines

Indications and Usage

  • Primarily prescribed for the treatment of insomnia.

Mechanism of Action

  • Functions as a benzodiazepine.
  • Acts as a positive allosteric modulator at the GABAA receptor.
  • Increases the duration of channel opening in response to GABA, leading to chloride ion influx and hyperpolarization of neurons.

Pharmacokinetics

  • Well absorbed with widespread distribution in the body.
  • 89% protein-binding capacity.
  • Metabolized by the liver.
  • Half-life ranges from 1.06 to 5.4 hours.

Time/Action Profile

  • Oral administration:
    • Onset of action: 15-30 minutes.
    • Peak effect: 6-8 hours.

Contraindications

  • Low serum albumin levels.
  • History of psychotic disorders.
  • Suicidal ideation.
  • Alcohol intoxication or substance abuse.
  • Depression and myasthenia gravis.
  • Asthma and liver dysfunction.
  • Sleep apnea and pregnancy.
  • Breastfeeding individuals.
  • Chronic obstructive pulmonary disease (COPD).
  • Complex sleep behaviors (e.g., sleep-driving).

Adverse Effects

  • Central nervous system (CNS) depression.
  • Anterograde amnesia.
  • Incidents of sleep driving.
  • Paradoxical reactions, including insomnia and heightened anxiety.
  • Respiratory depression risks.
  • Potential for abuse.
  • Use during pregnancy and lactation can be harmful as it may cross the placenta and enter breast milk.

Dosage Information

  • Typical dosage range: 0.125 to 0.25 mg.

Drug Interactions

  • Notable interactions with:
    • Itraconazole and ketoconazole (antifungals).
    • Nefazodone (antidepressant).
    • Indinavir, nelfinavir, ritonavir, saquinavir, lopinavir (antiviral agents).

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