BCH3120 Intermediary Metabolism: Adipokines and Inflammation
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Questions and Answers

What is the role of the hypothalamus in appetite regulation?

  • It is responsible for insulin production
  • It secretes ghrelin to increase appetite
  • It contains neural circuits that influence food intake (correct)
  • It produces leptin to decrease appetite
  • Which hormone is involved in increasing appetite according to the provided content?

  • Leptin
  • Insulin
  • PYY3-36 (correct)
  • GLP1
  • What is the function of ghrelin in appetite regulation?

  • Decreases appetite
  • Regulates insulin levels
  • Promotes leptin production
  • Increases appetite (correct)
  • Which organ is NOT mentioned as an appetite regulation center?

    <p>Thyroid gland</p> Signup and view all the answers

    What are the two hormones mentioned that originate from the hypothalamus in the context of appetite regulation?

    <p>PYY3-36 and Ghrelin</p> Signup and view all the answers

    Which ratio is used to calculate the respiratory exchange ratio (RER)?

    <p>VO2/VCO2</p> Signup and view all the answers

    What is the RER value for 100% glucose metabolism?

    <p>1</p> Signup and view all the answers

    Why do muscles shift from carbohydrate metabolism to fat metabolism during prolonged exercise?

    <p>Increased availability of fats</p> Signup and view all the answers

    What happens to fuel selection in muscles under high-intensity conditions?

    <p>Shift from fat to carbohydrate</p> Signup and view all the answers

    'Fat burns in the flame of carbohydrates' implies that:

    <p>Carbohydrates are essential for the complete metabolism of fats</p> Signup and view all the answers

    What is the main reason carbohydrates are crucial in fat metabolism?

    <p>Acetyl-CoA from fatty acid oxidation need the TCA cycle for ATP generation</p> Signup and view all the answers

    What are some processes that are reset during the slow component of recovery after exercise?

    <p>Rehydration and replenishment of glycogen reserves</p> Signup and view all the answers

    How long can the elevated VO2 levels last after exercise?

    <p>60 minutes</p> Signup and view all the answers

    What is the primary effect of a 6-week aerobic training program on VO2?

    <p>Increase in VO2</p> Signup and view all the answers

    Which enzyme is associated with endothelium-derived nitric oxide function in humans?

    <p>eNOS: Endoplasmic Reticulum Nitric Oxide Synthase</p> Signup and view all the answers

    What does exercise-dependent remodelling of blood vessels aim to achieve?

    <p>Vasodilation for easier blood delivery to muscles</p> Signup and view all the answers

    Which molecule is responsible for vasodilation in the context of exercise?

    <p>NO: Nitrogen Oxide</p> Signup and view all the answers

    What is the chronic issue exhibited by obese individuals?

    <p>Elevated IL6 levels</p> Signup and view all the answers

    How does obesity lead to insulin resistance?

    <p>Through adipokines imbalance and inflammation</p> Signup and view all the answers

    Which enzyme is responsible for increased expression during glucose uptake in the liver?

    <p>Glucokinase</p> Signup and view all the answers

    What is the consequence of insulin resistance on glycolysis and acetyl-CoA production?

    <p>Decreased pyruvate dehydrogenase complex activity</p> Signup and view all the answers

    How does hypoxia (obesity) affect the expression of adipokines?

    <p>Upregulates adipokines expression</p> Signup and view all the answers

    Where is adiponectin primarily produced?

    <p>Adipose tissue</p> Signup and view all the answers

    What is the consequence of reduced levels of carbohydrates on the TCA cycle?

    <p>Decreased rate of glycolysis</p> Signup and view all the answers

    Why does our body try to maintain a small reserve of carbohydrates in muscles?

    <p>To support TCA cycle activity</p> Signup and view all the answers

    What is the primary source of ATP during the initial phase of exercise?

    <p>ATP-phosphocreatine cycle</p> Signup and view all the answers

    How does reduced conversion of pyruvate to oxaloacetate impact the TCA cycle?

    <p>It slows down the TCA cycle</p> Signup and view all the answers

    What is the effect of low carbohydrate levels on acetyl-CoA entering the TCA cycle?

    <p>Only few acetyl-CoA enter the TCA cycle</p> Signup and view all the answers

    Why does oxygen uptake increase at the beginning of exercise?

    <p>To support ATP production via the ATP-phosphocreatine cycle</p> Signup and view all the answers

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