Podcast
Questions and Answers
Which of the following is true about the starting dose of basal insulin?
Which of the following is true about the starting dose of basal insulin?
- The starting dose is typically 8-10 units (correct)
- The starting dose is usually the end dose
- The starting dose is given in the morning
- The starting dose is adjusted based on the pre-dinner reading
What is the main message regarding the administration of subcutaneous insulin injections?
What is the main message regarding the administration of subcutaneous insulin injections?
- It is difficult for patients to manage
- It requires detailed dietary advice
- It can completely eliminate the risk of hypoglycemia
- It is easily managed by the patient (correct)
What is the 'start low go slow' approach?
What is the 'start low go slow' approach?
- Starting with a low insulin dose and increasing it slowly (correct)
- Starting with a high insulin dose and decreasing it quickly
- Starting with a high insulin dose and increasing it quickly
- Starting with a low insulin dose and decreasing it slowly
What is the suggested timeframe for a review during the early phases of insulin treatment?
What is the suggested timeframe for a review during the early phases of insulin treatment?
What is the suggested adjustment of insulin dose in insulin-resistant patients?
What is the suggested adjustment of insulin dose in insulin-resistant patients?
What is the advantage of continuing metformin and other agents at the commencement of insulin?
What is the advantage of continuing metformin and other agents at the commencement of insulin?
What is the suggested increase in total daily dosage of insulin when oral therapy is discontinued?
What is the suggested increase in total daily dosage of insulin when oral therapy is discontinued?
Which of the following is a core pathophysiological defect leading to the development of T2DM?
Which of the following is a core pathophysiological defect leading to the development of T2DM?
What is the term used to describe the impairment of beta cells due to 'glucolipotoxicity'?
What is the term used to describe the impairment of beta cells due to 'glucolipotoxicity'?
Which tissues play a key role in glucose homeostasis and are targets for newer therapies for T2DM?
Which tissues play a key role in glucose homeostasis and are targets for newer therapies for T2DM?
When should early insulin therapy be considered in a patient newly diagnosed with T2DM?
When should early insulin therapy be considered in a patient newly diagnosed with T2DM?
What should prompt consideration of T1DM as the diagnosis in a patient with T2DM?
What should prompt consideration of T1DM as the diagnosis in a patient with T2DM?
When is initiating insulin therapy in a patient newly diagnosed with T2DM unusual?
When is initiating insulin therapy in a patient newly diagnosed with T2DM unusual?
What should be considered when a patient with T2DM presents with marked ketonuria or ketoacidosis?
What should be considered when a patient with T2DM presents with marked ketonuria or ketoacidosis?
Which therapy is recommended as a second-line agent to metformin in the treatment of T2DM, depending on clinical context?
Which therapy is recommended as a second-line agent to metformin in the treatment of T2DM, depending on clinical context?
What is the recommended treatment for elderly patients without microvascular disease, whose prognosis is driven mainly by macrovascular risk and for whom stringent glycaemic control offers fewer benefits?
What is the recommended treatment for elderly patients without microvascular disease, whose prognosis is driven mainly by macrovascular risk and for whom stringent glycaemic control offers fewer benefits?
When should insulin treatment be considered in patients with an HbA1c above 9% on maximally tolerated oral therapy?
When should insulin treatment be considered in patients with an HbA1c above 9% on maximally tolerated oral therapy?
What is the 'legacy effect' of early good glycaemic control in diabetes?
What is the 'legacy effect' of early good glycaemic control in diabetes?
What is the primary aim when initiating insulin therapy in patients with T2DM?
What is the primary aim when initiating insulin therapy in patients with T2DM?
What is the average HbA1c reduction achieved by attention to lifestyle alone in patients with T2DM?
What is the average HbA1c reduction achieved by attention to lifestyle alone in patients with T2DM?
Which insulin formulations may be useful in patients who need to cover both fasting and post-prandial glucose?
Which insulin formulations may be useful in patients who need to cover both fasting and post-prandial glucose?
Which of the following is a possible option for controlling post-prandial rises in patients with elevated HbA1c?
Which of the following is a possible option for controlling post-prandial rises in patients with elevated HbA1c?
In patients with T2DM, is it usually necessary to provide detailed insulin-to-carbohydrate ratios?
In patients with T2DM, is it usually necessary to provide detailed insulin-to-carbohydrate ratios?
What is the purpose of administering a dummy injection of saline in early consultations for patients initiating insulin therapy?
What is the purpose of administering a dummy injection of saline in early consultations for patients initiating insulin therapy?
Which needle size is suitable for most patients initiating insulin therapy?
Which needle size is suitable for most patients initiating insulin therapy?
Who can provide great assistance in the management of insulin therapy in patients with T2DM?
Who can provide great assistance in the management of insulin therapy in patients with T2DM?
What should be reviewed in relation to driving licenses and occupational hazards in patients initiating insulin therapy?
What should be reviewed in relation to driving licenses and occupational hazards in patients initiating insulin therapy?
Can insulin therapy be initiated simply and safely in the ambulatory care setting?
Can insulin therapy be initiated simply and safely in the ambulatory care setting?
What can assist the successful transition to insulin therapy in patients with T2DM?
What can assist the successful transition to insulin therapy in patients with T2DM?
What is the typical age of onset for latent autoimmune diabetes in adults (LADA)?
What is the typical age of onset for latent autoimmune diabetes in adults (LADA)?
What is one characteristic that can help distinguish LADA from type 1 or type 2 diabetes?
What is one characteristic that can help distinguish LADA from type 1 or type 2 diabetes?
What is the key reason for establishing distinct practice guidelines for the diagnosis and treatment of LADA?
What is the key reason for establishing distinct practice guidelines for the diagnosis and treatment of LADA?
What is the main challenge in diagnosing LADA?
What is the main challenge in diagnosing LADA?
What is the primary aim when initiating insulin therapy in patients with type 2 diabetes?
What is the primary aim when initiating insulin therapy in patients with type 2 diabetes?
What is one characteristic of LADA that distinguishes it from type 1 diabetes?
What is one characteristic of LADA that distinguishes it from type 1 diabetes?
What is one characteristic of type 2 diabetes that can help distinguish it from LADA?
What is one characteristic of type 2 diabetes that can help distinguish it from LADA?
What is one characteristic of LADA that can help distinguish it from type 2 diabetes?
What is one characteristic of LADA that can help distinguish it from type 2 diabetes?
Which marker is often measured to differentiate the types of diabetes?
Which marker is often measured to differentiate the types of diabetes?
Which antibodies are commonly found in latent autoimmune diabetes in adults (LADA)?
Which antibodies are commonly found in latent autoimmune diabetes in adults (LADA)?
What is the proposed age criterion for diagnosing LADA?
What is the proposed age criterion for diagnosing LADA?
Which antibody is often negative in type 2 diabetes but can be positive in LADA?
Which antibody is often negative in type 2 diabetes but can be positive in LADA?
What is the recommended treatment for LADA?
What is the recommended treatment for LADA?
What is the main disadvantage of misdiagnosing LADA as type 2 diabetes?
What is the main disadvantage of misdiagnosing LADA as type 2 diabetes?
What is the characteristic decline of C-peptide levels in LADA compared to type 2 diabetes?
What is the characteristic decline of C-peptide levels in LADA compared to type 2 diabetes?
What is the proposed time frame for not treating LADA with insulin after diagnosis to meet the criteria?
What is the proposed time frame for not treating LADA with insulin after diagnosis to meet the criteria?
Which antibodies are often positive in LADA?
Which antibodies are often positive in LADA?
Which type of diabetes is estimated to have a prevalence of 1-2% of all diabetes cases?
Which type of diabetes is estimated to have a prevalence of 1-2% of all diabetes cases?
What genetic test was performed to confirm the diagnosis of GCK-MODY?
What genetic test was performed to confirm the diagnosis of GCK-MODY?
Which of the following is true about MODY diabetes?
Which of the following is true about MODY diabetes?
What is the genetic cause of GCK-MODY?
What is the genetic cause of GCK-MODY?
What is the recommended treatment for GCK-MODY?
What is the recommended treatment for GCK-MODY?
What is the characteristic feature of GCK-MODY?
What is the characteristic feature of GCK-MODY?
What is the significance of the negative result for the GCK variant in the parents of the patient?
What is the significance of the negative result for the GCK variant in the parents of the patient?
What is the purpose of the Oral Glucose Tolerance Test (OGTT) in the diagnosis of MODY?
What is the purpose of the Oral Glucose Tolerance Test (OGTT) in the diagnosis of MODY?
Which gene is associated with MODY and was confirmed in the patient described in the text?
Which gene is associated with MODY and was confirmed in the patient described in the text?
What is the characteristic of hyperglycemia in GCK-MODY?
What is the characteristic of hyperglycemia in GCK-MODY?
What is the prevalence of de novo mutations in GCK-MODY cases according to recent publications?
What is the prevalence of de novo mutations in GCK-MODY cases according to recent publications?
What is the first step in classifying a patient suspected of having MODY diabetes?
What is the first step in classifying a patient suspected of having MODY diabetes?
What is the main advantage of genetic evaluation in patients with clinical suspicion of MODY diabetes?
What is the main advantage of genetic evaluation in patients with clinical suspicion of MODY diabetes?
What is the key message regarding the frequency of other specific types of diabetes in Latin America?
What is the key message regarding the frequency of other specific types of diabetes in Latin America?
Which gene mutation is frequently misdiagnosed and unnecessarily treated as GCK-MODY?
Which gene mutation is frequently misdiagnosed and unnecessarily treated as GCK-MODY?
What is the term used to describe the condition of having both hypoglycemia and hyperglycemia syndromes caused by mutations in the glucokinase gene?
What is the term used to describe the condition of having both hypoglycemia and hyperglycemia syndromes caused by mutations in the glucokinase gene?
Which gene mutations may be more frequent in MODY than previously assumed?
Which gene mutations may be more frequent in MODY than previously assumed?
Which gene mutation is associated with maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia?
Which gene mutation is associated with maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia?
Which gene mutation is commonly found in latent autoimmune diabetes in adults (LADA)?
Which gene mutation is commonly found in latent autoimmune diabetes in adults (LADA)?
Which gene mutation should be considered when a patient with type 2 diabetes presents with marked ketonuria or ketoacidosis?
Which gene mutation should be considered when a patient with type 2 diabetes presents with marked ketonuria or ketoacidosis?
Which gene is associated with GCK-MODY, one of the most frequent subtypes of MODY?
Which gene is associated with GCK-MODY, one of the most frequent subtypes of MODY?
What is the estimated percentage of all diabetes cases that are accounted for by MODY?
What is the estimated percentage of all diabetes cases that are accounted for by MODY?
Which of the following is NOT a characteristic of MODY that can help in its diagnosis?
Which of the following is NOT a characteristic of MODY that can help in its diagnosis?
Which of the following statements about GCK-MODY is TRUE?
Which of the following statements about GCK-MODY is TRUE?
How many different GCK-MODY mutations have been reported to date?
How many different GCK-MODY mutations have been reported to date?
What is the genetic inheritance pattern of GCK-MODY?
What is the genetic inheritance pattern of GCK-MODY?
