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Basal Insulin Therapy for Type 2 Diabetes

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Basal Insulin Therapy for Type 2 Diabetes

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Questions and Answers

What is the maximum duration of effective insulin coverage with an NPH-based basal insulin regimen per injection?

18 hours

16 hours (correct)

20 hours

12 hours

What is the primary function of basal insulin in normal physiologic circumstances?

Stimulate hepatic glucose production

Stimulate glucose release into the circulation

Inhibit glucose uptake in peripheral tissues

Suppress hepatic glucose production and support glucose uptake (correct)

What is the purpose of individualized dose titration and insulin-to-carbohydrate ratio (ICR) in patients with type 2 diabetes?

To decrease insulin sensitivity

To increase insulin resistance

To induce hypoglycemia

To normalize blood glucose levels (correct)

What is the purpose of a three-day self-monitored blood glucose profile?

To adjust basal insulin dose based on actual blood glucose data Signup and view all the answers

What is the goal of adjusting basal insulin dosing based on patient's glycemic control and HbA1c level?

To achieve an HbA1c level of 7% Signup and view all the answers

What is the formula used to calculate the patient's Estimated Total Daily Dose (ETDD) of insulin?

Weight in kilograms x 0.5 units Signup and view all the answers

What is the primary goal of adjusting the dose of basal insulin in patients with type 2 diabetes mellitus?

To prevent hyper or hypoglycemia and achieve fasting blood glucose targets Signup and view all the answers

What is the typical regimen for traditional basal insulin therapy?

Once- or twice-daily subcutaneous injection of neutral protamine Hagedorn (NPH), insulin glargine, or insulin detemir Signup and view all the answers

What is the reason for the limited value of initial fixed-dose basal insulin therapy in early studies?

Lack of titration to achieve optimal insulin dose Signup and view all the answers

What is the prevalence of diabetes mellitus in the USA, according to the text?

13.4% in both males and females Signup and view all the answers

Why is basal insulin a key component of insulin therapy in type 2 diabetes mellitus?

It is essential in achieving glycemic goals Signup and view all the answers

What is the effect of changes in dietary habits, activity, or concomitant medications on the insulin dose?

It may make the current insulin dose either excessive or insufficient Signup and view all the answers