7 Questions
Which cells are selected to survive and become pre-B cells?
Cells that can make an Ig μ heavy-chain protein
What is the role of junctional nucleotides in V(D)J recombination?
To ensure a multiple of three nucleotides in the junction
What is the function of the pre-B cell receptor (pre-BCR) complex?
To signal the successful rearrangement of the Ig heavy-chain locus
Which process contributes to the diversity of immunoglobulins and T cell receptors?
All of the above
What is the estimated range of distinct B and T cell antigen receptors in humans?
10^8-10^9
Which cells assemble a complete membrane IgM receptor?
Mature B cells
What is the composition of the pre-BCR?
Membrane-associated Ig μ protein and two other proteins called surrogate light chains
Study Notes
B Cell Development
- Large, cycling cells that express CD19 and contain DJH rearrangements are selected to survive and become pre-B cells.
V(D)J Recombination
- Junctional nucleotides play a crucial role in V(D)J recombination by adding random nucleotides at the junctions of rearranged gene segments, contributing to the diversity of immunoglobulins and T cell receptors.
Pre-B Cell Receptor (Pre-BCR) Complex
- The pre-BCR complex, composed of μ heavy chains and surrogate light chains, is responsible for signaling cell survival and proliferation in pre-B cells.
Immunoglobulin and T Cell Receptor Diversity
- The process of V(D)J recombination, including the random addition of junctional nucleotides, contributes to the vast diversity of immunoglobulins and T cell receptors, estimated to be in the range of 10^11 to 10^18 distinct receptors in humans.
Pre-B Cell Receptor Assembly
- Pre-B cells assemble a complete membrane IgM receptor, composed of μ heavy chains and light chains.
Pre-BCR Composition
- The pre-BCR complex is composed of μ heavy chains and surrogate light chains, λ5 and VpreB.
Quiz: Understanding B Cell Development and Ig Heavy-Chain Rearrangement Test your knowledge on B cell development and the process of Ig heavy-chain rearrangement. Learn about the selection of pre-B cells, the joining of D and J segments, and the recombination of V gene segments.
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