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B Cell Development and Ig Heavy-Chain Rearrangement Quiz

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B Cell Development and Ig Heavy-Chain Rearrangement Quiz

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Questions and Answers

Which cells are selected to survive and become pre-B cells?

Cells that can make an Ig μ heavy-chain protein (correct)

Cells that divide rapidly

Cells that have undergone V(D)J recombination

Cells with a functional Igα and Igβ signaling molecules

What is the role of junctional nucleotides in V(D)J recombination?

To add diversity to the Ig heavy-chain protein

To ensure a multiple of three nucleotides in the junction (correct)

To prevent the formation of functional heavy-chain gene rearrangements

To select the appropriate V and J segments

What is the function of the pre-B cell receptor (pre-BCR) complex?

To promote cell division in pre-B cells

To signal the successful rearrangement of the Ig heavy-chain locus (correct)

To transport Igα and Igβ signaling molecules

To initiate V(D)J recombination

Which process contributes to the diversity of immunoglobulins and T cell receptors?

All of the above Signup and view all the answers

What is the estimated range of distinct B and T cell antigen receptors in humans?

10^8-10^9 Signup and view all the answers

Which cells assemble a complete membrane IgM receptor?

Mature B cells Signup and view all the answers

What is the composition of the pre-BCR?

Membrane-associated Ig μ protein and two other proteins called surrogate light chains Signup and view all the answers

Study Notes

B Cell Development

Large, cycling cells that express CD19 and contain DJH rearrangements are selected to survive and become pre-B cells.

V(D)J Recombination

Junctional nucleotides play a crucial role in V(D)J recombination by adding random nucleotides at the junctions of rearranged gene segments, contributing to the diversity of immunoglobulins and T cell receptors.

Pre-B Cell Receptor (Pre-BCR) Complex

The pre-BCR complex, composed of μ heavy chains and surrogate light chains, is responsible for signaling cell survival and proliferation in pre-B cells.

Immunoglobulin and T Cell Receptor Diversity

The process of V(D)J recombination, including the random addition of junctional nucleotides, contributes to the vast diversity of immunoglobulins and T cell receptors, estimated to be in the range of 10^11 to 10^18 distinct receptors in humans.

Pre-B Cell Receptor Assembly

Pre-B cells assemble a complete membrane IgM receptor, composed of μ heavy chains and light chains.

Pre-BCR Composition

The pre-BCR complex is composed of μ heavy chains and surrogate light chains, λ5 and VpreB.

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Description

Quiz: Understanding B Cell Development and Ig Heavy-Chain Rearrangement Test your knowledge on B cell development and the process of Ig heavy-chain rearrangement. Learn about the selection of pre-B cells, the joining of D and J segments, and the recombination of V gene segments.