Podcast
Questions and Answers
Which cells are selected to survive and become pre-B cells?
Which cells are selected to survive and become pre-B cells?
- Cells that can make an Ig μ heavy-chain protein (correct)
- Cells that divide rapidly
- Cells that have undergone V(D)J recombination
- Cells with a functional Igα and Igβ signaling molecules
What is the role of junctional nucleotides in V(D)J recombination?
What is the role of junctional nucleotides in V(D)J recombination?
- To add diversity to the Ig heavy-chain protein
- To ensure a multiple of three nucleotides in the junction (correct)
- To prevent the formation of functional heavy-chain gene rearrangements
- To select the appropriate V and J segments
What is the function of the pre-B cell receptor (pre-BCR) complex?
What is the function of the pre-B cell receptor (pre-BCR) complex?
- To promote cell division in pre-B cells
- To signal the successful rearrangement of the Ig heavy-chain locus (correct)
- To transport Igα and Igβ signaling molecules
- To initiate V(D)J recombination
Which process contributes to the diversity of immunoglobulins and T cell receptors?
Which process contributes to the diversity of immunoglobulins and T cell receptors?
What is the estimated range of distinct B and T cell antigen receptors in humans?
What is the estimated range of distinct B and T cell antigen receptors in humans?
Which cells assemble a complete membrane IgM receptor?
Which cells assemble a complete membrane IgM receptor?
What is the composition of the pre-BCR?
What is the composition of the pre-BCR?
Flashcards
Pre-B cell selection
Pre-B cell selection
The process where cells capable of making Ig μ heavy-chain proteins survive and become pre-B cells.
Junctional nucleotides
Junctional nucleotides
They ensure a multiple of three nucleotides at the V(D)J recombination junction.
Pre-BCR function
Pre-BCR function
Signals the successful rearrangement of the Ig heavy-chain gene.
Ig diversity
Ig diversity
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B and T receptor count
B and T receptor count
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Mature B cell receptor
Mature B cell receptor
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Pre-BCR composition
Pre-BCR composition
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V(D)J recombination
V(D)J recombination
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Ig μ chain
Ig μ chain
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B-cell receptors
B-cell receptors
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Study Notes
B Cell Development
- Large, cycling cells that express CD19 and contain DJH rearrangements are selected to survive and become pre-B cells.
V(D)J Recombination
- Junctional nucleotides play a crucial role in V(D)J recombination by adding random nucleotides at the junctions of rearranged gene segments, contributing to the diversity of immunoglobulins and T cell receptors.
Pre-B Cell Receptor (Pre-BCR) Complex
- The pre-BCR complex, composed of μ heavy chains and surrogate light chains, is responsible for signaling cell survival and proliferation in pre-B cells.
Immunoglobulin and T Cell Receptor Diversity
- The process of V(D)J recombination, including the random addition of junctional nucleotides, contributes to the vast diversity of immunoglobulins and T cell receptors, estimated to be in the range of 10^11 to 10^18 distinct receptors in humans.
Pre-B Cell Receptor Assembly
- Pre-B cells assemble a complete membrane IgM receptor, composed of μ heavy chains and light chains.
Pre-BCR Composition
- The pre-BCR complex is composed of μ heavy chains and surrogate light chains, λ5 and VpreB.
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