Podcast
Questions and Answers
Where do pluripotent stem cells give rise to distinct B and T cell lineages?
Where do pluripotent stem cells give rise to distinct B and T cell lineages?
Bone marrow
Where are protein antigens recognized by specific B and T lymphocytes?
Where are protein antigens recognized by specific B and T lymphocytes?
Peripheral lymphoid organs
What is the lifespan of extrafollicular plasma cells?
What is the lifespan of extrafollicular plasma cells?
Short-lived (~3 days)
Where do follicular/germinal center plasma cells migrate to?
Where do follicular/germinal center plasma cells migrate to?
How are naive B cells activated in the follicles?
How are naive B cells activated in the follicles?
Where are naive CD4+ T cells activated by antigen processed and presented by dendritic cells?
Where are naive CD4+ T cells activated by antigen processed and presented by dendritic cells?
Where do helper T cells and activated B cells interact to initiate the initial antibody response?
Where do helper T cells and activated B cells interact to initiate the initial antibody response?
Where do most immature B cells complete their maturation before migrating to other peripheral lymphoid organs?
Where do most immature B cells complete their maturation before migrating to other peripheral lymphoid organs?
What is the fate of immature B cells that leave the bone marrow?
What is the fate of immature B cells that leave the bone marrow?
Which subset of B cells arise from fetal liver-derived stem cells and are found in peritoneal and pleural cavity fluid?
Which subset of B cells arise from fetal liver-derived stem cells and are found in peritoneal and pleural cavity fluid?
Where are follicular B cells mainly located?
Where are follicular B cells mainly located?
What is the role of subcapsular sinus macrophages in B cell activation?
What is the role of subcapsular sinus macrophages in B cell activation?
How are antigens in immune complexes delivered to follicular B cells?
How are antigens in immune complexes delivered to follicular B cells?
What is the role of Activation-induced cytidine deaminase (AID) in B cell function?
What is the role of Activation-induced cytidine deaminase (AID) in B cell function?
What is affinity maturation and how does it occur in a T-dependent humoral response?
What is affinity maturation and how does it occur in a T-dependent humoral response?
Explain the process of class switching in B cells.
Explain the process of class switching in B cells.
What is somatic hypermutation and where does it predominantly occur?
What is somatic hypermutation and where does it predominantly occur?
How does the process of heavy chain isotype switching contribute to antibody diversity?
How does the process of heavy chain isotype switching contribute to antibody diversity?
What is the function of FDCs in relation to class II MHC molecules?
What is the function of FDCs in relation to class II MHC molecules?
How does the recombination of VDJ exon and C region DNA contribute to B cell function?
How does the recombination of VDJ exon and C region DNA contribute to B cell function?
Explain the significance of selective survival of B cells with high-affinity antibodies in affinity maturation.
Explain the significance of selective survival of B cells with high-affinity antibodies in affinity maturation.
Where does Ig heavy chain isotype switching occur in the B cell development pathway?
Where does Ig heavy chain isotype switching occur in the B cell development pathway?
What initiates the generation of point mutations in the variable region of expressed immunoglobulin genes?
What initiates the generation of point mutations in the variable region of expressed immunoglobulin genes?
