B and T Cell Differentiation Process Quiz
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Questions and Answers

What is the primary function of the medullary thymic epithelial cells (MTECs) in the thymus?

  • To form the Hassall corpuscles in the medulla of the thymus
  • To provide a rich vascular supply and efferent lymphatic vessels to the thymus
  • To produce lymphocyte precursors derived from the bone marrow
  • To present self-antigens to developing T cells and cause their elimination (correct)

    • Which of the following cell types are derived from the bone marrow and found in the thymus?

  • Macrophages and lymphocyte precursors (correct)
  • Hassall corpuscles
  • Epithelial cells
  • Medullary thymic epithelial cells (MTECs)

    • What is the origin of the epithelial component of the thymus?

  • Differentiation of lymphocyte precursors derived from the bone marrow
  • Transformation of Hassall corpuscles in the medulla of the thymus
  • Proliferation of medullary thymic epithelial cells (MTECs)
  • Invaginations of the ectoderm in the developing neck and chest of the embryo (correct)

    • What is the function of the Hassall corpuscles found in the medulla of the thymus?

    <p>To serve as remnants of degenerating epithelial cells</p> Signup and view all the answers

    What is the primary function of the efferent lymphatic vessels that drain the thymus?

    <p>To drain into mediastinal lymph nodes</p> Signup and view all the answers

    What is the main function of Langerhans cells?

    <p>Presenting antigens to T cells</p> Signup and view all the answers

    Which type of cells express TLRs and other innate pattern recognition receptors?

    <p>Mast cells</p> Signup and view all the answers

    Where do epidermal Langerhans cells and dermal dendritic cells present peptide-MHC complexes?

    <p>In draining lymph nodes</p> Signup and view all the answers

    Which cells are activated by cytokines secreted by keratinocytes and sentinel cells?

    <p>ILCs</p> Signup and view all the answers

    What is the function of fibroblasts in the immune response?

    <p>Being involved in immune responses</p> Signup and view all the answers

    Which cell type is known for its role in producing granulocyte-macrophage colony-stimulating factor?

    <p>Keratinocytes</p> Signup and view all the answers

    Which statement about B cells is correct?

    <p>B cells mature and differentiate in the bone marrow</p> Signup and view all the answers

    Where do committed T cell precursors undergo final differentiation?

    <p>Thymus</p> Signup and view all the answers

    Which cells found in the bone marrow are permanently differentiated?

    <p>Some natural killer (NK) cells</p> Signup and view all the answers

    Which cells are responsible for the development of humoral immunological memory?

    <p>Long-lived plasma cells</p> Signup and view all the answers

    What is the function of the thymus?

    <p>Site of T cell maturation</p> Signup and view all the answers

    Which cells in the thymus produce cytokines required for early T cell development?

    <p>Cortical epithelial cells</p> Signup and view all the answers

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