17 Questions
What is the primary function of the medullary thymic epithelial cells (MTECs) in the thymus?
To present self-antigens to developing T cells and cause their elimination
Which of the following cell types are derived from the bone marrow and found in the thymus?
Macrophages and lymphocyte precursors
What is the origin of the epithelial component of the thymus?
Invaginations of the ectoderm in the developing neck and chest of the embryo
What is the function of the Hassall corpuscles found in the medulla of the thymus?
To serve as remnants of degenerating epithelial cells
What is the primary function of the efferent lymphatic vessels that drain the thymus?
To drain into mediastinal lymph nodes
What is the main function of Langerhans cells?
Presenting antigens to T cells
Which type of cells express TLRs and other innate pattern recognition receptors?
Mast cells
Where do epidermal Langerhans cells and dermal dendritic cells present peptide-MHC complexes?
In draining lymph nodes
Which cells are activated by cytokines secreted by keratinocytes and sentinel cells?
ILCs
What is the function of fibroblasts in the immune response?
Being involved in immune responses
Which cell type is known for its role in producing granulocyte-macrophage colony-stimulating factor?
Keratinocytes
Which statement about B cells is correct?
B cells mature and differentiate in the bone marrow
Where do committed T cell precursors undergo final differentiation?
Thymus
Which cells found in the bone marrow are permanently differentiated?
Some natural killer (NK) cells
Which cells are responsible for the development of humoral immunological memory?
Long-lived plasma cells
What is the function of the thymus?
Site of T cell maturation
Which cells in the thymus produce cytokines required for early T cell development?
Cortical epithelial cells
Test your knowledge on the multiple expansion and selection steps of B cells and T cells during their differentiation process from bone marrow to secondary lymphoid organs. Understand the migration and final differentiation of T-cell precursors in the thymus, and the differentiation of NK cells in different tissues.
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