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B and T Cell Differentiation Process Quiz

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B and T Cell Differentiation Process Quiz

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Questions and Answers

What is the primary function of the medullary thymic epithelial cells (MTECs) in the thymus?

To form the Hassall corpuscles in the medulla of the thymus

To provide a rich vascular supply and efferent lymphatic vessels to the thymus

To produce lymphocyte precursors derived from the bone marrow

To present self-antigens to developing T cells and cause their elimination (correct)

Which of the following cell types are derived from the bone marrow and found in the thymus?

Macrophages and lymphocyte precursors (correct)

Hassall corpuscles

Epithelial cells

Medullary thymic epithelial cells (MTECs)

What is the origin of the epithelial component of the thymus?

Differentiation of lymphocyte precursors derived from the bone marrow

Transformation of Hassall corpuscles in the medulla of the thymus

Proliferation of medullary thymic epithelial cells (MTECs)

Invaginations of the ectoderm in the developing neck and chest of the embryo (correct)

What is the function of the Hassall corpuscles found in the medulla of the thymus?

To serve as remnants of degenerating epithelial cells (C) Signup and view all the answers

What is the primary function of the efferent lymphatic vessels that drain the thymus?

To drain into mediastinal lymph nodes (C) Signup and view all the answers

What is the main function of Langerhans cells?

Presenting antigens to T cells (A) Signup and view all the answers

Which type of cells express TLRs and other innate pattern recognition receptors?

Mast cells (A) Signup and view all the answers

Where do epidermal Langerhans cells and dermal dendritic cells present peptide-MHC complexes?

In draining lymph nodes (D) Signup and view all the answers

Which cells are activated by cytokines secreted by keratinocytes and sentinel cells?

ILCs (A) Signup and view all the answers

What is the function of fibroblasts in the immune response?

Being involved in immune responses (B) Signup and view all the answers

Which cell type is known for its role in producing granulocyte-macrophage colony-stimulating factor?

Keratinocytes (B) Signup and view all the answers

Which statement about B cells is correct?

B cells mature and differentiate in the bone marrow (D) Signup and view all the answers

Where do committed T cell precursors undergo final differentiation?

Thymus (C) Signup and view all the answers

Which cells found in the bone marrow are permanently differentiated?

Some natural killer (NK) cells (D) Signup and view all the answers

Which cells are responsible for the development of humoral immunological memory?

Long-lived plasma cells (C) Signup and view all the answers

What is the function of the thymus?

Site of T cell maturation (D) Signup and view all the answers

Which cells in the thymus produce cytokines required for early T cell development?

Cortical epithelial cells (C) Signup and view all the answers