Autoimmune Skin Diseases in Dogs and Cats Quiz

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Questions and Answers

Which form of pemphigus is characterized by lesions formed just above the basal cell layer?

Pemphigus erythematosus

Discoid Lupus Erythematosus

Pemphigus foliaceus

Pemphigus vulgaris (correct)

Which breed seems to be over-represented in cases of pemphigus foliaceus?

Labradors

Chow Chows

Akitas

B and C (correct)

What are the primary lesions associated with pemphigus foliaceus?

Pustules (correct)

Alopecia

Collarettes

Crusts

Which autoimmune skin disease is considered the most common in dogs and cats?

Pemphigus foliaceus Signup and view all the answers

What is the condition characterized by a specific humoral or cell-mediated immune response against the component of adhesion molecules on keratinocytes?

Autoimmunity Signup and view all the answers

What are the superficial forms of pemphigus?

Pemphigus foliaceus, pemphigus erythematous Signup and view all the answers

What is the hallmark of pemphigus?

Acantholysis Signup and view all the answers

In which locations are the lesions typically found in pemphigus foliaceus?

Nasal planum, ear pinnae, footpads Signup and view all the answers

What are the systemic signs associated with pemphigus foliaceus?

Lymphadenomegaly, limb edema, fever, anorexia, and depression Signup and view all the answers

What are the targeted adhesion molecules in pemphigus complex?

Desmoglein or desmocollin Signup and view all the answers

What is a common presentation of pemphigus foliaceus in cats and dogs?

Starting on the bridge of the nose, around the eyes, and pinnae before becoming generalized Signup and view all the answers

Which diagnostic methods are involved in the diagnosis of pemphigus foliaceus?

Cytology of pustules, dermatohistopathology, and direct/indirect immunofluorescence Signup and view all the answers

Which form of pemphigus is uncommon in dogs and rare in cats?

Pemphigus erythematosus Signup and view all the answers

What are the common affected breeds with increased incidence of pemphigus erythematosus?

German shepherds, collies, and Shetland sheepdogs Signup and view all the answers

What regions are affected by pemphigus vulgaris?

Mucocutaneous regions, nail beds, inguinal, and axillary areas Signup and view all the answers

What are the common clinical signs of animals affected by pemphigus?

Anorexia, fever, and depression Signup and view all the answers

What conditions are part of the differential diagnosis for pemphigus foliaceus?

Bullous pemphigoid, systemic lupus erythematosus, and other conditions Signup and view all the answers

What do cytology and histopathology show in pemphigus vulgaris?

Acanthocytes and neutrophils; suprabasilar acantholysis and cleft forming a vesicle or bulla Signup and view all the answers

What is the rare form of pemphigus that is severe and affects mucocutaneous regions?

Pemphigus vulgaris Signup and view all the answers

What is a rare presentation of pemphigus foliaceus in cats?

Oral lesions and mucocutaneous involvement Signup and view all the answers

Which autoimmune skin disease involves hair follicles and requires aggressive treatment?

Pemphigus Complex Signup and view all the answers

What is hypothesized to trigger Discoid Lupus Erythematosus (DLE) in dogs?

Ultraviolet light and specific autoantibodies Signup and view all the answers

What are the clinical signs of DLE in dogs?

Nasal depigmentation, ulcers, and crusts exacerbated by sunlight Signup and view all the answers

What is a potential complication of treatment for autoimmune skin diseases in dogs and cats?

Drug adverse effects Signup and view all the answers

What is included in the treatment for Discoid Lupus Erythematosus (DLE) in dogs?

Systemic vitamin E, tetracycline and niacinamide, topical steroids, and tacrolimus Signup and view all the answers

What may not be diagnostic for Discoid Lupus Erythematosus (DLE) in dogs?

Direct immunofluorescence Signup and view all the answers

What is the second most common autoimmune skin disease in dogs?

Discoid Lupus Erythematosus (DLE) Signup and view all the answers

What is a differential diagnosis for DLE in dogs?

Nasal pyoderma, pemphigus foliaceus, and uveodermatologic syndrome Signup and view all the answers

What may show characteristic changes in the diagnosis of DLE in dogs?

Histopathology Signup and view all the answers

What may be required for severe cases of DLE in dogs?

Systemic steroids, oral cyclosporine, and lifelong treatment with sun precautions Signup and view all the answers

Study Notes

Autoimmune Skin Diseases in Dogs and Cats

Pemphigus Complex involves hair follicles and requires aggressive treatment
Treatment includes oral glucocorticoids, cytotoxic drugs, glucocorticoid pulse therapy, mycophenolate mofetil, and leflunomide
Patient response to therapy is unpredictable, and there are potentially severe side effects
Complications of treatment include drug adverse effects, secondary infections, and demodicosis
Discoid Lupus Erythematosus (DLE) is the second most common autoimmune skin disease in dogs
DLE is hypothesized to be triggered by ultraviolet light and specific autoantibodies
Clinical signs of DLE include nasal depigmentation, ulcers, and crusts exacerbated by sunlight
Differential diagnoses for DLE include nasal pyoderma, pemphigus foliaceus, and uveodermatologic syndrome
Cytology may show no significant findings, while histopathology reveals characteristic changes
Direct immunofluorescence may not be diagnostic for DLE
Treatment for DLE includes systemic vitamin E, tetracycline and niacinamide, topical steroids, and tacrolimus
Severe cases may require systemic steroids, oral cyclosporine, and lifelong treatment with sun precautions

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Description

Test your knowledge of autoimmune skin diseases in dogs and cats with this quiz. Explore topics such as Pemphigus Complex, Discoid Lupus Erythematosus (DLE), treatment options, and differential diagnoses.