Autoimmune skin diseases quiz
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Questions and Answers

Which immune mechanism is involved in facial cutaneous lupus erythematosus?

  • T-cells (correct)
  • Antibodies
  • Neutrophils
  • Both antibodies and T-cells

    • What is the main differential diagnosis for vitiligo?

  • Mucocutaneous pyoderma
  • Epitheliotropic lymphoma
  • Depigmentation caused by any inflammatory disease (correct)
  • Depigmentation caused by melanocytes themselves

    • Which immune mechanism is involved in sebaceous adenitis?

  • Neutrophils
  • Both antibodies and T-cells
  • T-cells (correct)
  • Antibodies

    • What is the main differential diagnosis for panniculitis?

    <p>Both tumours and deep infections</p> Signup and view all the answers

    Which target is affected in vasculitis?

    <p>Dermal blood vessels</p> Signup and view all the answers

    Which immune mechanism is involved in vasculitis?

    <p>Antibodies</p> Signup and view all the answers

    Which target is affected in panniculitis?

    <p>Subcuticular fat</p> Signup and view all the answers

    What is the main differential diagnosis for facial cutaneous lupus erythematosus?

    <p>Epitheliotropic lymphoma</p> Signup and view all the answers

    Which type of hypersensitivity is often involved in vasculitis?

    <p>Type III</p> Signup and view all the answers

    What is the main target of the antibody attack in Pemphigus foliaceus?

    <p>Desmosomal proteins in upper part of epidermis</p> Signup and view all the answers

    Which cells form rounded acantholytic keratinocytes in Pemphigus foliaceus?

    <p>Basal epidermis cells</p> Signup and view all the answers

    What is the main presentation of Pemphigus foliaceus?

    <p>Pustules rapidly developing into crusts</p> Signup and view all the answers

    Which condition is characterized by laminated crusts and alopecia in dogs, cats, and horses?

    <p>Superficial pyoderma</p> Signup and view all the answers

    Which type of hypersensitivity involves T-cells?

    <p>Type IV</p> Signup and view all the answers

    What is the main target tissue of antibody attack in CIMDs?

    <p>Desmosomal proteins in upper epidermis</p> Signup and view all the answers

    What is the immune-mechanism involved in Pemphigus foliaceus?

    <p>Antibody attack</p> Signup and view all the answers

    What forms when pustules disintegrate in Pemphigus foliaceus?

    <p>Layers of heaped crusts</p> Signup and view all the answers

    What is the main differential diagnosis for Pemphigus foliaceus?

    <p>Superficial pyoderma</p> Signup and view all the answers

    Which of the following is a potential cause of Sterile pyogranulomatous dermatitis and panniculitis (SPDP)?

    <p>Autoimmune disease</p> Signup and view all the answers

    What is a potential differential diagnosis for soft fluctuating nodules that rupture and discharge fatty goo in cats?

    <p>Mycobacteria infections</p> Signup and view all the answers

    Which organ can be affected by vasculitis associated with cutaneous immune-mediated diseases?

    <p>Kidneys</p> Signup and view all the answers

    What is the purpose of performing cytology in the diagnosis of pemphigus?

    <p>To detect abnormal immune cells</p> Signup and view all the answers

    What is the recommended biopsy technique for obtaining a diagnostic lesion in cutaneous immune-mediated diseases?

    <p>Biopsy from an area of no self-trauma</p> Signup and view all the answers

    Which of the following is NOT a major dermatological presenting sign of cutaneous immune-mediated diseases?

    <p>Fever</p> Signup and view all the answers

    Which of the following is NOT a potential cause of Sterile pyogranulomatous dermatitis and panniculitis (SPDP)?

    <p>Bacterial infection</p> Signup and view all the answers

    What is the purpose of exclusion in the diagnosis of cutaneous immune-mediated diseases?

    <p>To identify common differential diagnoses</p> Signup and view all the answers

    What is the recommended number of biopsies to obtain a good sample for diagnosis in cutaneous immune-mediated diseases?

    <p>4-6</p> Signup and view all the answers

    What are the target tissues affected in cutaneous immune mediated diseases?

    <p>Desmosomal proteins in the upper epidermis, cells of the basal epidermis, sebaceous glands, dermal skin vessels, subcuticular fat</p> Signup and view all the answers

    What is the predominant hypersensitivity type involved in cutaneous immune mediated diseases?

    <p>Type II (antibodies - IgG), Type III (immune-complex disease), Type IV (T-cells)</p> Signup and view all the answers

    What is the main presentation of Pemphigus foliaceus?

    <p>Pustules rapidly developing into crusts, leaving erosions</p> Signup and view all the answers

    What is the main differential diagnosis for panniculitis?

    <p>Sterile pyogranulomatous dermatitis and panniculitis (SPDP)</p> Signup and view all the answers

    What is a potential differential diagnosis for soft fluctuating nodules that rupture and discharge fatty goo in cats?

    <p>Superficial pyoderma</p> Signup and view all the answers

    What are the potential causes of Sterile pyogranulomatous dermatitis and panniculitis (SPDP)?

    <ol> <li>pancreatic neoplasia 2. pancreatitis 3. polyarthritis 4. systemic lupus erythematosus</li> </ol> Signup and view all the answers

    What are the possible areas of the body that can be affected by vasculitis associated with cutaneous immune-mediated diseases?

    <p>Kidneys (glomerulonephropathy), joints (immune-mediated arthropathy), and eyes (retinal haemorrhage)</p> Signup and view all the answers

    What is the purpose of exclusion in the diagnosis of cutaneous immune-mediated diseases?

    <p>To rule out common differential diagnoses</p> Signup and view all the answers

    What is the recommended number of biopsies to obtain a good sample for diagnosis in cutaneous immune-mediated diseases?

    <p>4-6 biopsies</p> Signup and view all the answers

    What is the main target tissue of antibody attack in CIMDs?

    <p>The tissue/antigen involved is the main determinant of the clinical signs</p> Signup and view all the answers

    What are the main differential diagnoses for facial cutaneous lupus erythematosus?

    <p>Main differential diagnoses for facial cutaneous lupus erythematosus include mucocutaneous pyoderma and epitheliotropic lymphoma.</p> Signup and view all the answers

    What is the immune mechanism involved in vasculitis?

    <p>The immune mechanism involved in vasculitis is antibody (± antibody–immune complexes).</p> Signup and view all the answers

    What is the main target tissue of antibody attack in CIMDs?

    <p>The main target tissue of antibody attack in cutaneous immune-mediated diseases (CIMDs) is dermal blood vessels.</p> Signup and view all the answers

    What is the main target of the antibody attack in Pemphigus foliaceus?

    <p>The main target of the antibody attack in Pemphigus foliaceus is desmoglein-1, a protein present in the desmosomes of keratinocytes.</p> Signup and view all the answers

    What is the main differential diagnosis for panniculitis?

    <p>The main differential diagnosis for panniculitis includes tumors and deep infections (e.g., M. bovis).</p> Signup and view all the answers

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