Autoimmune Down Regulation of Receptors and Pernicious Anemia
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Questions and Answers

What is the most common feature of autoimmune diseases?

  • Decreased blood cell maturation
  • Muscle weakness and paralysis
  • Underproduction of hormones
  • Overproduction of autoantibodies (correct)

Which autoimmune disease is associated with a female to male ratio of 3:2?

  • Grave's disease
  • Myasthenia gravis
  • Hashimoto's thyroiditis
  • Pernicious anemia (correct)

What is the primary treatment for Hashimoto's thyroiditis?

  • Thyroid hormone replacement therapy (correct)
  • Daily insulin injections
  • Immunosuppressive drugs
  • Acetylcholine esterase inhibitors

Which autoimmune disease is characterized by the production of autoantibodies that block the uptake of vitamin B12?

<p>Pernicious anemia (D)</p> Signup and view all the answers

What is the primary treatment for Myasthenia gravis?

<p>Acetylcholine esterase inhibitors (A)</p> Signup and view all the answers

Which one of the following is a key feature of systemic lupus erythematosus (SLE)?

<p>Chronic inflammation characterized by the presence of HLA-DR3 (C)</p> Signup and view all the answers

What type of hypersensitivity reaction is primarily responsible for the tissue damage seen in SLE?

<p>Type III (immune complex) hypersensitivity (C)</p> Signup and view all the answers

Which of the following is a characteristic autoantibody found in patients with rheumatoid arthritis (RA)?

<p>Rheumatoid factor (C)</p> Signup and view all the answers

What is the primary role of HEp-2 cells in the diagnosis of autoimmune disorders?

<p>They allow the recognition of over 30 different nuclear and cytoplasmic patterns associated with various autoimmune disorders. (C)</p> Signup and view all the answers

Which of the following is a characteristic feature of Graves' disease, an autoimmune thyroid disorder?

<p>Presence of antibodies against the thyroid-stimulating hormone (TSH) receptor (A)</p> Signup and view all the answers

Which of the following autoimmune disorders is associated with the presence of anti-acetylcholine receptor antibodies?

<p>Myasthenia gravis (B)</p> Signup and view all the answers

What type of hypersensitivity reactions are associated with Hashimoto's thyroiditis?

<p>Type IV (A)</p> Signup and view all the answers

Which autoimmune disease is characterized by autoantibodies that mimic the effect of thyroid stimulating hormone on specific receptors?

<p>Grave's Disease (B)</p> Signup and view all the answers

In Grave's Disease, what is the gender ratio between females and males?

<p>7:1 (B)</p> Signup and view all the answers

Which autoimmune disease involves autoantibodies that block neuromuscular transmission from cholinergic neurons?

<p>Myasthenia Gravis (C)</p> Signup and view all the answers

What laboratory features are typically seen in Rheumatoid Arthritis?

<p>Elevated ESR and CRP levels (D)</p> Signup and view all the answers

Which HLA-DR antigen is associated with an increased frequency of Hashimoto's thyroiditis?

<p>HLA-DR3 (C)</p> Signup and view all the answers

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