Autoimmune Down Regulation of Receptors and Pernicious Anemia

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What is the most common feature of autoimmune diseases?

Overproduction of autoantibodies

Which autoimmune disease is associated with a female to male ratio of 3:2?

Pernicious anemia

What is the primary treatment for Hashimoto's thyroiditis?

Thyroid hormone replacement therapy

Which autoimmune disease is characterized by the production of autoantibodies that block the uptake of vitamin B12?

<p>Pernicious anemia</p> Signup and view all the answers

What is the primary treatment for Myasthenia gravis?

<p>Acetylcholine esterase inhibitors</p> Signup and view all the answers

Which one of the following is a key feature of systemic lupus erythematosus (SLE)?

<p>Chronic inflammation characterized by the presence of HLA-DR3</p> Signup and view all the answers

What type of hypersensitivity reaction is primarily responsible for the tissue damage seen in SLE?

<p>Type III (immune complex) hypersensitivity</p> Signup and view all the answers

Which of the following is a characteristic autoantibody found in patients with rheumatoid arthritis (RA)?

<p>Rheumatoid factor</p> Signup and view all the answers

What is the primary role of HEp-2 cells in the diagnosis of autoimmune disorders?

<p>They allow the recognition of over 30 different nuclear and cytoplasmic patterns associated with various autoimmune disorders.</p> Signup and view all the answers

Which of the following is a characteristic feature of Graves' disease, an autoimmune thyroid disorder?

<p>Presence of antibodies against the thyroid-stimulating hormone (TSH) receptor</p> Signup and view all the answers

Which of the following autoimmune disorders is associated with the presence of anti-acetylcholine receptor antibodies?

<p>Myasthenia gravis</p> Signup and view all the answers

What type of hypersensitivity reactions are associated with Hashimoto's thyroiditis?

<p>Type IV</p> Signup and view all the answers

Which autoimmune disease is characterized by autoantibodies that mimic the effect of thyroid stimulating hormone on specific receptors?

<p>Grave's Disease</p> Signup and view all the answers

In Grave's Disease, what is the gender ratio between females and males?

<p>7:1</p> Signup and view all the answers

Which autoimmune disease involves autoantibodies that block neuromuscular transmission from cholinergic neurons?

<p>Myasthenia Gravis</p> Signup and view all the answers

What laboratory features are typically seen in Rheumatoid Arthritis?

<p>Elevated ESR and CRP levels</p> Signup and view all the answers

Which HLA-DR antigen is associated with an increased frequency of Hashimoto's thyroiditis?

<p>HLA-DR3</p> Signup and view all the answers

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