Autoimmune Diseases and Gender Differences

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What happens when autoimmune diseases occur?

The immune system attacks the body's tissues

Why are women more likely to get autoimmune diseases than men?

Due to differences in how the body handles females' second X chromosome

How many chromosomes are typically found in a human cell?

23 pairs

Which autoimmune disorder is NOT mentioned in the text?

Type 2 Diabetes

What did E. John Wherry say about the new research?

"the way we think about this whole process of autoimmunity."

What is one theory behind why women are more prone to autoimmune diseases?

The presence of two X chromosomes in females

What is the name of the special kind of RNA responsible for X-chromosome inactivation?

Xist

What did Dr. Howard Chang's lab find attached to Xist during their exploration?

Nearly 100 proteins

Why does Xist by itself not cause autoimmune disease in all women?

It takes a combination of genes and an environmental event to cause autoimmune problems.

What did researchers discover about male mice with artificially produced Xist when exposed to a lupus-like condition?

They developed lupus-like autoimmunity similar to females.

Why did researchers look at blood from 100 patients in addition to studying mice?

To identify autoantibodies targeting Xist-related proteins

What does Dr. Wherry suggest the findings about autoantibodies targeting Xist-related proteins could provide doctors with?

A quicker way to diagnose patients with autoimmune conditions

Learn about how new research may explain why women are more likely to get autoimmune diseases than men. Discover the connection between the body's immune system and the second X chromosome in females. Explore the potential impact of this finding on improving the detection of autoimmune diseases.

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