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Questions and Answers
What is the reason why certain microbes can trigger autoimmunity?
What is the reason why certain microbes can trigger autoimmunity?
- They share cross-reacting epitopes with self-antigens (correct)
- They are unable to induce an immune response
- They are only found in the digestive system
- They have a weakened immune response
Which of the following is NOT a mechanism of self-tolerance?
Which of the following is NOT a mechanism of self-tolerance?
- Breakdown of T-cell anergy (correct)
- Release of sequestered antigens
- T-cell–mediated suppression
- MHC–antigen receptor/complex interactions
What is the probable cause of rheumatic heart disease?
What is the probable cause of rheumatic heart disease?
- An immune response against Klebsiella organisms
- A failure of T-cell–mediated suppression
- A disorder of MHC–antigen receptor/complex interactions
- An immune response against streptococci (correct)
Why do autoimmune diseases tend to run in families?
Why do autoimmune diseases tend to run in families?
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What is the name of the phenomenon where the immune response to a microbial antigen cross-reacts with self-tissues?
What is the name of the phenomenon where the immune response to a microbial antigen cross-reacts with self-tissues?
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What is the result of the breakdown of self-tolerance?
What is the result of the breakdown of self-tolerance?
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