Autoimmune Disease Mechanisms
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Questions and Answers

What is the reason why certain microbes can trigger autoimmunity?

  • They share cross-reacting epitopes with self-antigens (correct)
  • They are unable to induce an immune response
  • They are only found in the digestive system
  • They have a weakened immune response

    • Which of the following is NOT a mechanism of self-tolerance?

  • Breakdown of T-cell anergy (correct)
  • Release of sequestered antigens
  • T-cell–mediated suppression
  • MHC–antigen receptor/complex interactions

    • What is the probable cause of rheumatic heart disease?

  • An immune response against Klebsiella organisms
  • A failure of T-cell–mediated suppression
  • A disorder of MHC–antigen receptor/complex interactions
  • An immune response against streptococci (correct)

    • Why do autoimmune diseases tend to run in families?

    <p>Due to the inheritance of various susceptibility genes</p> Signup and view all the answers

    What is the name of the phenomenon where the immune response to a microbial antigen cross-reacts with self-tissues?

    <p>Molecular mimicry</p> Signup and view all the answers

    What is the result of the breakdown of self-tolerance?

    <p>The development of autoimmune diseases</p> Signup and view all the answers

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