11 Questions
What is the defining characteristic of asthma according to the provided text?
Recurrent and reversible obstruction of the airways
What is the distribution of bronchial hyperreactivity in the general population?
Unimodal
What mediators are involved in the inflammatory changes in the airways during asthma pathophysiology?
Leukotrienes and PAF
Which cells are recruited to the airways during asthma pathophysiology?
Mast cells and eosinophils
What is one common trigger for bronchospasm in individuals with asthma?
Physical exercise
What effect does inhalation of an allergen have on airway smooth muscle in individuals with asthma?
Contraction leading to airway narrowing
What is the range of heritability percentage in asthma susceptibility studies?
25-80%
Which gene was the first to be identified as an asthma susceptibility gene?
ADAM-33
Which category of genes are associated with Th2 cell signaling in asthma susceptibility?
Th2 cell signaling genes
Which chromosomal location is associated with asthma susceptibility according to GWAS?
Chr18
Which factor plays a role in lung development in relation to asthma susceptibility?
ADAM33
Test your knowledge on the definition of asthma syndrome, including its characteristics like recurrent attacks, reversibility, and airway obstruction. Explore the operational definition and the concept of stimuli in relation to asthma.
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