Asthma Overview and Management
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Questions and Answers

What are key pathophysiologic features and contributing factors to asthma severity and control?

What are the key assessment components when collecting asthma-specific history and physical exam?

What are common diagnostic and monitoring methods for asthma?

How can the NAEPP EPR3 Guidelines classification system be applied to assess asthma severity and control?

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What does it mean to practice applying treatment guidelines for stepwise approach to asthma pharmacotherapy?

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How can pharmacotherapeutic management be individualized to a patient's specific needs and comorbidities?

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What are the appropriate delivery techniques for common asthma devices including metered-dose inhalers and nebulizer therapy?

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What are the key elements of asthma education and how can common myths be addressed?

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What does NAEPP stand for?

<p>National Asthma Education &amp; Prevention Program</p> Signup and view all the answers

What does EPR-3 stand for?

<p>Expert Panel Report #3</p> Signup and view all the answers

What does FEV1 represent?

<p>Forced expiratory volume in 1st second</p> Signup and view all the answers

What does FVC signify?

<p>Forced vital capacity</p> Signup and view all the answers

What does MDI stand for?

<p>Metered-dose inhaler</p> Signup and view all the answers

What does VHC mean?

<p>Valved-Holding Chamber</p> Signup and view all the answers

What does ICS stand for?

<p>Inhaled corticosteroid</p> Signup and view all the answers

What does SABA represent?

<p>Short-acting beta2-agonist</p> Signup and view all the answers

What does LABA mean?

<p>Long-acting beta2-agonist</p> Signup and view all the answers

What does LTRA signify?

<p>Leukotriene receptor antagonist</p> Signup and view all the answers

What does CFC stand for?

<p>Chlorofluorocarbon</p> Signup and view all the answers

What does HFA represent?

<p>Hydrofluoroalkane</p> Signup and view all the answers

What does DPI stand for?

<p>Dry powder inhaler</p> Signup and view all the answers

What is the burden of asthma?

<p>Asthma is one of the most common chronic diseases worldwide.</p> Signup and view all the answers

What was the purpose of the National Asthma Education & Prevention Program (NAEPP)?

<p>To address the growing problem of asthma</p> Signup and view all the answers

What summarization does the EPR-3 provide?

<p>Summarizes extensive evidence that guidelines lead to reduced asthma symptoms.</p> Signup and view all the answers

Asthma is ____

<p>a chronic inflammatory disorder of the airways characterized by variable and recurring symptoms.</p> Signup and view all the answers

What are the characteristics of chronic airway inflammation in asthma?

<p>Mast cell activation, inflammatory cell infiltration, edema, and smooth muscle thickening.</p> Signup and view all the answers

What are the risk factors for developing asthma?

<p>Family history, socioeconomic factors, race/ethnicity.</p> Signup and view all the answers

Study Notes

Asthma Overview

  • Asthma affects approximately 300 million individuals globally, making it one of the most prevalent chronic diseases.
  • Increasing asthma prevalence, particularly in children, is noted in many countries.
  • Asthma leads to significant absenteeism from school and work, with high healthcare expenditures—1-2% of healthcare spending in developed nations, rising demand in developing economies.
  • Poorly controlled asthma can be costly; investing in preventive medication can reduce emergency care costs.

National Asthma Education & Prevention Program (NAEPP)

  • Established by the NHLBI in 1989 to combat the increasing asthma problem.
  • Initial Expert Panel Report (EPR) was published in 1991, with revisions in subsequent years (EPR-2 in 1997, updates in 2002, and EPR-3 in August 2007).
  • EPR-3 outlines significant evidence-based guidelines aimed at reducing asthma symptoms and improving quality of life.

Asthma Medical Management

  • Asthma is characterized as a chronic inflammatory disease of the airways with recurring symptoms, airflow obstruction, and bronchial hyper-responsiveness.
  • Management involves recognizing pathophysiological features, assessing severity through NAEPP EPR-3 guidelines, and tailoring treatments based on individual patient needs and comorbidities.
  • Six treatment steps within the EPR-3 guidelines facilitate a stepwise approach to asthma pharmacotherapy, promoting step-up or step-down strategies as needed.

Common Asthma Devices

  • Metered-Dose Inhalers (MDI) are essential for delivering short-acting and long-acting bronchodilators.
  • Valved-Holding Chambers (VHC) enhance MDI medication delivery and efficacy.
  • Dry Powder Inhalers (DPI) provide a convenient alternative for patients, ensuring proper technique is crucial for effectiveness.
  • Nebulizer therapy is an option for extensive delivery of medications, especially in severe cases.

Risk Factors for Asthma

  • Genetic predisposition significantly increases the likelihood of developing asthma, particularly with a family history of the condition.
  • Other contributing factors include socioeconomic status, race/ethnicity, gender variations, prematurity or low birth weight, and environmental influences such as maternal smoking and dietary habits lacking fruits and vegetables.

Asthma Inflammation Characteristics

  • The chronic airway inflammation associated with asthma involves activation of mast cells and infiltration by various inflammatory cells (eosinophils, macrophages, neutrophils, lymphocytes).
  • Features include airway edema, goblet cell hyperplasia resulting in excessive mucus production, and smooth muscle thickening, which can lead to irreversible airway remodeling.

Key Terms

  • FEV1: Forced Expiratory Volume in 1st second; an important measure of lung function.
  • FVC: Forced Vital Capacity; total volume of air forcibly exhaled after a deep breath.
  • ICS: Inhaled Corticosteroid; anti-inflammatory medication used in asthma control.
  • SABA: Short-acting Beta2-agonist; typically used as a rescue inhaler for immediate relief.
  • LABA: Long-acting Beta2-agonist; used for ongoing asthma management.
  • LTRA: Leukotriene Receptor Antagonist; another class of medication to help manage asthma symptoms.

Education and Myths

  • Essential elements include education on asthma management, recognizing and dispelling common myths, especially when communicating with children and families.

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Description

Explore the global impact of asthma, its increasing prevalence, and the efforts undertaken by the National Asthma Education & Prevention Program. Understand the significance of medical management and the importance of preventive care in controlling this chronic disease.

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