17 Questions
What is the mechanism of action of Theophylline in producing bronchodilation?
Inhibition of PDE isozymes, blockade of adenosine receptors, inhibition of calcium influx, and enhancement of catecholamine secretion
What is the therapeutic range of Theophylline for COPD and Asthma?
5 to 15 mg/mL
What is the role of Corticosteroids in the treatment of asthma?
Cornerstone of therapy for patients with moderate to severe asthma, as the most efficacious anti-inflammatory drug
How do Muscarinic Antagonists, such as Ipratropium and Tiotropium, produce their bronchodilating effect?
By blocking the bronchoconstricting effect of vagus (parasympathetic) nerve stimulation
What is the advantage of combining Ipratropium with beta-2 agonists, such as Salbutamol?
Greater bronchodilating effect than either drug alone
What is the characteristic that distinguishes Indacaterol from other bronchodilators?
It is the only once-daily bronchodilator for COPD
What is the primary function of beta-2 adrenoceptor agonists in the treatment of asthma?
To relax bronchial smooth muscles by increasing cAMP concentrations.
What is the difference between SABA's and LABA's in terms of administration and treatment?
SABA's are given by inhalation for acute bronchospasm, while LABA's are given twice daily by inhalation for long-term treatment of asthma.
What type of anti-inflammatory drug is commonly used to treat asthma?
Corticosteroids.
What is the mechanism of action of muscarinic receptor antagonists in asthma treatment?
Not specified in the text.
What is the benefit of using inhaled bronchodilators compared to oral formulations?
Inhaled bronchodilators prevent systemic adverse effects.
What is the role of leukotriene receptor antagonists in asthma treatment?
Not specified in the text.
What is asthma characterized by?
airway inflammation and hyperresponsiveness to stimuli that produce bronchoconstriction
What are some common triggers of asthma attacks?
allergens, air pollution, cigarettes smoking, other noxious chemicals, upper respiratory tract infections, drugs (NSAIDs, Beta-blockers), cold air, and exercise
What type of medication is used to relieve bronchospasm and is often used in inhalers?
Bronchodilators
What type of medication is used to reduce inflammation in the airways and is often used in combination with bronchodilators?
Corticosteroids
What type of medication is used to block the action of acetylcholine on the airways and is often used to treat COPD?
Muscarinic Antagonists
This quiz covers the pathogenesis of asthma, including trigger factors, airway inflammation, and hypersecretion of mucus. It also explores treatment options such as bronchodilators, anti-inflammatory drugs, and more. Test your knowledge of asthma and its management!
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