Asthma: Pathogenesis and Treatment

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What is the mechanism of action of Theophylline in producing bronchodilation?

Inhibition of PDE isozymes, blockade of adenosine receptors, inhibition of calcium influx, and enhancement of catecholamine secretion

What is the therapeutic range of Theophylline for COPD and Asthma?

5 to 15 mg/mL

What is the role of Corticosteroids in the treatment of asthma?

Cornerstone of therapy for patients with moderate to severe asthma, as the most efficacious anti-inflammatory drug

How do Muscarinic Antagonists, such as Ipratropium and Tiotropium, produce their bronchodilating effect?

By blocking the bronchoconstricting effect of vagus (parasympathetic) nerve stimulation Signup and view all the answers

What is the advantage of combining Ipratropium with beta-2 agonists, such as Salbutamol?

Greater bronchodilating effect than either drug alone Signup and view all the answers

What is the characteristic that distinguishes Indacaterol from other bronchodilators?

It is the only once-daily bronchodilator for COPD Signup and view all the answers

What is the primary function of beta-2 adrenoceptor agonists in the treatment of asthma?

To relax bronchial smooth muscles by increasing cAMP concentrations. Signup and view all the answers

What is the difference between SABA's and LABA's in terms of administration and treatment?

SABA's are given by inhalation for acute bronchospasm, while LABA's are given twice daily by inhalation for long-term treatment of asthma. Signup and view all the answers

What type of anti-inflammatory drug is commonly used to treat asthma?

Corticosteroids. Signup and view all the answers

What is the mechanism of action of muscarinic receptor antagonists in asthma treatment?

Not specified in the text. Signup and view all the answers

What is the benefit of using inhaled bronchodilators compared to oral formulations?

Inhaled bronchodilators prevent systemic adverse effects. Signup and view all the answers

What is the role of leukotriene receptor antagonists in asthma treatment?

Not specified in the text. Signup and view all the answers

What is asthma characterized by?

airway inflammation and hyperresponsiveness to stimuli that produce bronchoconstriction Signup and view all the answers

What are some common triggers of asthma attacks?

allergens, air pollution, cigarettes smoking, other noxious chemicals, upper respiratory tract infections, drugs (NSAIDs, Beta-blockers), cold air, and exercise Signup and view all the answers

What type of medication is used to relieve bronchospasm and is often used in inhalers?

Bronchodilators Signup and view all the answers

What type of medication is used to reduce inflammation in the airways and is often used in combination with bronchodilators?

Corticosteroids Signup and view all the answers

What type of medication is used to block the action of acetylcholine on the airways and is often used to treat COPD?

Muscarinic Antagonists Signup and view all the answers

Asthma: Pathogenesis and Treatment

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