Effects of Aspirin and NSAIDs

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Questions and Answers

Which of the following adverse effects is most likely to occur in patients with asthma who are taking NSAIDs?

  • Headache
  • Tinnitus
  • Dizziness
  • Asthma exacerbations (correct)

What percentage of patients taking aspirin may experience hypersensitivity reactions?

  • 5%
  • 10%
  • 15% (correct)
  • 20%

In patients with severe hypersensitivity to aspirin, what should they avoid using to prevent adverse reactions?

  • Naproxen
  • COX inhibitors
  • Warfarin
  • NSAIDs (correct)

Which plasma protein can aspirin displace, leading to increased concentration of free salicylate in the blood?

<p>Albumin (C)</p> Signup and view all the answers

What is the mechanism behind the antiplatelet effect of aspirin?

<p>Inhibition of thromboxane A2 synthesis (C)</p> Signup and view all the answers

What is the primary mechanism of action of Acetaminophen in the central nervous system?

<p>Inhibits prostaglandin synthesis (D)</p> Signup and view all the answers

Why is Acetaminophen considered weak in its anti-inflammatory activity in peripheral tissues?

<p>Peripheral inactivation (D)</p> Signup and view all the answers

How does Acetaminophen differ from NSAIDs in terms of platelet function?

<p>It does not affect platelet function (A)</p> Signup and view all the answers

When is Acetaminophen commonly used in patients instead of NSAIDs?

<p>For patients with gastric complaints (A)</p> Signup and view all the answers

What role does N-acetyl-p benzoquinoneimine (NAPQI) play in Acetaminophen metabolism?

<p>Reacts with glutathione to prevent liver damage (B)</p> Signup and view all the answers

What is a characteristic pharmacokinetic property of Acetaminophen in the liver?

<p>Undergoes high first-pass metabolism (D)</p> Signup and view all the answers

Why is Acetaminophen preferred over aspirin for children with viral infections or chickenpox?

<p>Higher risk of Reye syndrome with aspirin (A)</p> Signup and view all the answers

How does NAPQI become non-toxic at normal doses of Acetaminophen?

<p>Reacts with sulfhydryl groups to form a non-toxic substance (D)</p> Signup and view all the answers

In which forms is Acetaminophen available for administration?

<p>Intravenous and rectal formulations (A)</p> Signup and view all the answers

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