Effects of Aspirin and NSAIDs
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Questions and Answers

Which of the following adverse effects is most likely to occur in patients with asthma who are taking NSAIDs?

  • Headache
  • Tinnitus
  • Dizziness
  • Asthma exacerbations (correct)
  • What percentage of patients taking aspirin may experience hypersensitivity reactions?

  • 5%
  • 10%
  • 15% (correct)
  • 20%
  • In patients with severe hypersensitivity to aspirin, what should they avoid using to prevent adverse reactions?

  • Naproxen
  • COX inhibitors
  • Warfarin
  • NSAIDs (correct)
  • Which plasma protein can aspirin displace, leading to increased concentration of free salicylate in the blood?

    <p>Albumin</p> Signup and view all the answers

    What is the mechanism behind the antiplatelet effect of aspirin?

    <p>Inhibition of thromboxane A2 synthesis</p> Signup and view all the answers

    What is the primary mechanism of action of Acetaminophen in the central nervous system?

    <p>Inhibits prostaglandin synthesis</p> Signup and view all the answers

    Why is Acetaminophen considered weak in its anti-inflammatory activity in peripheral tissues?

    <p>Peripheral inactivation</p> Signup and view all the answers

    How does Acetaminophen differ from NSAIDs in terms of platelet function?

    <p>It does not affect platelet function</p> Signup and view all the answers

    When is Acetaminophen commonly used in patients instead of NSAIDs?

    <p>For patients with gastric complaints</p> Signup and view all the answers

    What role does N-acetyl-p benzoquinoneimine (NAPQI) play in Acetaminophen metabolism?

    <p>Reacts with glutathione to prevent liver damage</p> Signup and view all the answers

    What is a characteristic pharmacokinetic property of Acetaminophen in the liver?

    <p>Undergoes high first-pass metabolism</p> Signup and view all the answers

    Why is Acetaminophen preferred over aspirin for children with viral infections or chickenpox?

    <p>Higher risk of Reye syndrome with aspirin</p> Signup and view all the answers

    How does NAPQI become non-toxic at normal doses of Acetaminophen?

    <p>Reacts with sulfhydryl groups to form a non-toxic substance</p> Signup and view all the answers

    In which forms is Acetaminophen available for administration?

    <p>Intravenous and rectal formulations</p> Signup and view all the answers

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