ASPEN Clinical Guideline: Blood Glucose Goal Range

Hyperglycemia and Nutrition Support

• Hyperglycemia is a common occurrence in adult hospitalized patients receiving nutrition support.
• Both hyperglycemia and hypoglycemia are associated with adverse outcomes in diabetic and nondiabetic patients.

Guidelines for Glucose Control

• The American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) recommends a target blood glucose goal range of 140–180 mg/dL (7.8–10 mmol/L) in adult hospitalized patients receiving nutrition support.
• Hypoglycemia is defined as a blood glucose concentration of <70 mg/dL (3.9 mmol/L) in adult hospitalized patients receiving nutrition support.

Development of Clinical Guideline

• A systematic review of the best available evidence was conducted to answer questions regarding glucose control in adults receiving parenteral or enteral nutrition.
• The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) working group's concepts were used to evaluate the evidence.
• A consensus process was used to develop the clinical guideline recommendations, which were then reviewed and approved by the A.S.P.E.N. Board of Directors.