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Questions and Answers
What is unique about the replication of arenaviruses?
What is unique about the replication of arenaviruses?
- It requires an envelope
- It occurs in the cytoplasm (correct)
- It requires a unique receptor
- It occurs in the nucleus
What is the shape of the arenavirus capsid?
What is the shape of the arenavirus capsid?
- Icosahedral
- Spherical
- Helical (correct)
- Fibrous
What is the mode of transmission of arenaviruses to humans?
What is the mode of transmission of arenaviruses to humans?
- Airborne
- Rodent-borne (correct)
- Vector-borne
- Waterborne
What is the disease caused by Lymphocytic choriomeningitis virus (LCV)?
What is the disease caused by Lymphocytic choriomeningitis virus (LCV)?
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What is the mortality rate of hemorrhagic fever caused by arenaviruses in West Africa?
What is the mortality rate of hemorrhagic fever caused by arenaviruses in West Africa?
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Study Notes
Arenavirus Characteristics
- Has a single-stranded negative sense RNA genome
- Replicates in the cytoplasm
- Enveloped virus with a helical shaped capsid
- Can encode both negative and positive sense RNA
- Spiral banners represent the helical shape of the capsid
- Characterized by a granular, sandy outer capsid appearance on electron microscopy
Transmission and Disease
- Typically transmitted through rodents
- Causes diseases in humans, including lymphocytic choriomeningitis virus (LCV)
- LCV causes febrile aseptic meningitides
- May also cause hemorrhagic fever with a high mortality rate (up to 50%) in West Africa
Sensitivity and Inactivation
- Inactivated by heating, low pH, irradiation, and detergents
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