Adenovirus Structure and Replication

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Questions and Answers

What is the approximate length of the adenovirus DNA?

  • 36 Kb (correct)
  • 50 Kb
  • 18 Kb
  • 60 Kb

How many serotypes of adenovirus are associated with human disease?

  • 30
  • 40
  • 60
  • 52 (correct)

What is the name of the drug used to treat severe cases of adenovirus infection?

  • Interferon
  • Ribavirin
  • Cidofovir (correct)
  • Acyclovir

What is the route of administration of the live attenuated adenovirus vaccine?

<p>Oral (C)</p> Signup and view all the answers

What is the approximate size of the papillomavirus particle?

<p>50-55 nm (B)</p> Signup and view all the answers

How is human papillomavirus typically transmitted?

<p>Through direct contact or contaminated fomites (B)</p> Signup and view all the answers

What is the mode of transmission of Human Papillomavirus (HPV)?

<p>Through direct contact or contaminated fomites (D)</p> Signup and view all the answers

What is the typical incubation period for warts to appear after HPV infection?

<p>Up to 3 months (A)</p> Signup and view all the answers

What is the primary site of replication for Human Papillomavirus (HPV)?

<p>Epithelial tissue (B)</p> Signup and view all the answers

What is the purpose of the Pap smear test?

<p>To detect abnormal cervical cells (D)</p> Signup and view all the answers

What is the high-risk serotype associated with cervical cancer?

<p>HPV-16 and HPV-18 (D)</p> Signup and view all the answers

What is the result of partial integration of the HPV genome?

<p>High expression of the E6 and E7 genes (B)</p> Signup and view all the answers

What is the most serious complication of measles?

<p>Subacute sclerosing panencephalitis (SSPE) (C)</p> Signup and view all the answers

What is the characteristic of flat plantar warts?

<p>Deep, possibly painful wart on soles of feet (C)</p> Signup and view all the answers

What is the estimated rate of measles vaccination in the US?

<p>~92% (A)</p> Signup and view all the answers

What is the typical manifestation of HPV infection in children?

<p>Laryngeal papillomas (A)</p> Signup and view all the answers

What is the treatment option for warts?

<p>Chemical applications and physical removal (C)</p> Signup and view all the answers

Which Human Parainfluenza Virus (HPIV) serotype is more often associated with bronchiolitis, bronchitis, and pneumonia?

<p>3 (A)</p> Signup and view all the answers

What is the estimated percentage of children who have antibodies against HPIV-3 by age 5?

<p>75% (C)</p> Signup and view all the answers

What is the seroprevalence of HPV in the population?

<p>85% (C)</p> Signup and view all the answers

What is the primary reservoir of the mumps virus?

<p>Humans (D)</p> Signup and view all the answers

What is the estimated reduction in mumps incidence in the US after vaccination?

<p>99% (A)</p> Signup and view all the answers

What is the most common cause of lower respiratory tract infections among young children in the US?

<p>RSV (C)</p> Signup and view all the answers

What is the portal of entry for Respiratory Syncytial Virus (RSV) infection?

<p>Nose (A)</p> Signup and view all the answers

What is the recommended treatment for high-risk infants to prevent RSV infection?

<p>Synagis (C)</p> Signup and view all the answers

In what year were two new vaccines approved for 60+ adults to prevent RSV infection?

<p>2023 (D)</p> Signup and view all the answers

What is the primary function of the Neuraminidase protein in the influenza virus?

<p>Hydrolyzes mucus and facilitates virus movement through mucin layer (C)</p> Signup and view all the answers

What is the main reason why annual vaccination is necessary for influenza?

<p>To combat the constant genetic changes in the hemagglutinin and neuraminidase proteins (C)</p> Signup and view all the answers

What is the percentage of people who can be asymptomatic carriers of influenza based on serology?

<p>70% (C)</p> Signup and view all the answers

What is the main difference between influenza A and influenza B?

<p>Influenza A undergoes antigenic shift, while influenza B does not (B)</p> Signup and view all the answers

What is the function of the Hemagglutinin protein in the influenza virus?

<p>Facilitates binding to host cells and fusion (B)</p> Signup and view all the answers

What is the incubation period of influenza?

<p>1-5 days (D)</p> Signup and view all the answers

What is the name of the HPV vaccine that protects against 9 subtypes?

<p>Gardasil 9 (C)</p> Signup and view all the answers

What is the complication of influenza that accounts for approximately 25% of mortality?

<p>Pneumonia (C)</p> Signup and view all the answers

What is the number of RNA segments in the influenza C virus?

<p>7 (A)</p> Signup and view all the answers

What is the primary difference between Influenza B and Influenza C?

<p>Influenza B only undergoes antigenic drift (D)</p> Signup and view all the answers

What is the primary reservoir of influenza A?

<p>Birds (C)</p> Signup and view all the answers

What is the mechanism of action of Xofluza?

<p>Inhibits the endonuclease activity of the PA protein (B)</p> Signup and view all the answers

What is the age range for which Flu Mist is not recommended?

<p>Adults over 49 years (D)</p> Signup and view all the answers

What is the primary replication site of the Measles virus?

<p>Respiratory tract (A)</p> Signup and view all the answers

What is the purpose of the PA protein in Influenza replication?

<p>To facilitate 'cap stealing' during mRNA synthesis (B)</p> Signup and view all the answers

What is the characteristic rash of Measles caused by?

<p>T cells targeting measles-infected endothelial cells (C)</p> Signup and view all the answers

What is the difference between Traditional and Flucelvax vaccines?

<p>Flucelvax is produced in tissue culture and lacks egg antigen, while Traditional is produced in eggs (B)</p> Signup and view all the answers

What is the purpose of Zanamivir and Tamiflu in Flu treatment?

<p>To inhibit the activity of Neuraminidase (A)</p> Signup and view all the answers

What is the common feature of Paramyxovirus Replication?

<p>All of the above (D)</p> Signup and view all the answers

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