45 Questions
What is the approximate length of the adenovirus DNA?
36 Kb
How many serotypes of adenovirus are associated with human disease?
52
What is the name of the drug used to treat severe cases of adenovirus infection?
Cidofovir
What is the route of administration of the live attenuated adenovirus vaccine?
Oral
What is the approximate size of the papillomavirus particle?
50-55 nm
How is human papillomavirus typically transmitted?
Through direct contact or contaminated fomites
What is the mode of transmission of Human Papillomavirus (HPV)?
Through direct contact or contaminated fomites
What is the typical incubation period for warts to appear after HPV infection?
Up to 3 months
What is the primary site of replication for Human Papillomavirus (HPV)?
Epithelial tissue
What is the purpose of the Pap smear test?
To detect abnormal cervical cells
What is the high-risk serotype associated with cervical cancer?
HPV-16 and HPV-18
What is the result of partial integration of the HPV genome?
High expression of the E6 and E7 genes
What is the most serious complication of measles?
Subacute sclerosing panencephalitis (SSPE)
What is the characteristic of flat plantar warts?
Deep, possibly painful wart on soles of feet
What is the estimated rate of measles vaccination in the US?
~92%
What is the typical manifestation of HPV infection in children?
Laryngeal papillomas
What is the treatment option for warts?
Chemical applications and physical removal
Which Human Parainfluenza Virus (HPIV) serotype is more often associated with bronchiolitis, bronchitis, and pneumonia?
3
What is the estimated percentage of children who have antibodies against HPIV-3 by age 5?
75%
What is the seroprevalence of HPV in the population?
85%
What is the primary reservoir of the mumps virus?
Humans
What is the estimated reduction in mumps incidence in the US after vaccination?
99%
What is the most common cause of lower respiratory tract infections among young children in the US?
RSV
What is the portal of entry for Respiratory Syncytial Virus (RSV) infection?
Nose
What is the recommended treatment for high-risk infants to prevent RSV infection?
Synagis
In what year were two new vaccines approved for 60+ adults to prevent RSV infection?
2023
What is the primary function of the Neuraminidase protein in the influenza virus?
Hydrolyzes mucus and facilitates virus movement through mucin layer
What is the main reason why annual vaccination is necessary for influenza?
To combat the constant genetic changes in the hemagglutinin and neuraminidase proteins
What is the percentage of people who can be asymptomatic carriers of influenza based on serology?
70%
What is the main difference between influenza A and influenza B?
Influenza A undergoes antigenic shift, while influenza B does not
What is the function of the Hemagglutinin protein in the influenza virus?
Facilitates binding to host cells and fusion
What is the incubation period of influenza?
1-5 days
What is the name of the HPV vaccine that protects against 9 subtypes?
Gardasil 9
What is the complication of influenza that accounts for approximately 25% of mortality?
Pneumonia
What is the number of RNA segments in the influenza C virus?
7
What is the primary difference between Influenza B and Influenza C?
Influenza B only undergoes antigenic drift
What is the primary reservoir of influenza A?
Birds
What is the mechanism of action of Xofluza?
Inhibits the endonuclease activity of the PA protein
What is the age range for which Flu Mist is not recommended?
Adults over 49 years
What is the primary replication site of the Measles virus?
Respiratory tract
What is the purpose of the PA protein in Influenza replication?
To facilitate 'cap stealing' during mRNA synthesis
What is the characteristic rash of Measles caused by?
T cells targeting measles-infected endothelial cells
What is the difference between Traditional and Flucelvax vaccines?
Flucelvax is produced in tissue culture and lacks egg antigen, while Traditional is produced in eggs
What is the purpose of Zanamivir and Tamiflu in Flu treatment?
To inhibit the activity of Neuraminidase
What is the common feature of Paramyxovirus Replication?
All of the above
Learn about the structure and replication of Adenovirus, a non-enveloped dsDNA virus that infects lymphoid tissue, respiratory and intestinal epithelia, and conjunctiva. Understand its transmission and treatment options. This quiz covers the basics of Adenovirus, its association with human diseases, and vaccine availability.
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