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Questions and Answers
What is the role of CAD in DNA fragmentation during apoptosis?
What is the role of CAD in DNA fragmentation during apoptosis?
- CAD inhibits the endonuclease activity
- CAD prevents the cleavage of iCAD
- CAD cuts the chromosomal DNA between nucleosomes (correct)
- CAD promotes the formation of apoptotic nuclei
What is the consequence of cleavage of iCAD?
What is the consequence of cleavage of iCAD?
- Inhibition of DNA fragmentation
- Activation of executioner caspases
- Unleashing of the nuclease CAD (correct)
- Formation of apoptotic nuclei
How are DNA fragments separated by size during gel electrophoresis?
How are DNA fragments separated by size during gel electrophoresis?
- Based on their mobility in the gel (correct)
- Based on their nucleotide sequence
- Based on their association with iCAD
- Based on their fluorescence intensity
What is the purpose of adding a fluorescent label to DNA ends in the mentioned technique?
What is the purpose of adding a fluorescent label to DNA ends in the mentioned technique?
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What happens to the fragments during gel electrophoresis when cleavages occur in the linker regions between nucleosomes?
What happens to the fragments during gel electrophoresis when cleavages occur in the linker regions between nucleosomes?
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