Apoptotic DNA Fragmentation Quiz

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Questions and Answers

What is the role of CAD in DNA fragmentation during apoptosis?

  • CAD cuts the chromosomal DNA between nucleosomes (correct)
  • CAD inhibits the production of DNA fragments
  • CAD activates the executioner caspases
  • CAD stabilizes the iCAD inhibitor

What happens to iCAD during apoptosis?

  • iCAD is cleaved by executioner caspases (correct)
  • iCAD activates DNA fragmentation
  • iCAD stabilizes the chromosomal DNA
  • iCAD inhibits CAD activity

What is the result of DNA fragmentation during apoptosis on gel electrophoresis?

  • Formation of a single band
  • Formation of a ladder pattern (correct)
  • Formation of a random pattern
  • No change in the DNA pattern

Why are smaller molecules more widely separated in the lower part of the gel during electrophoresis?

<p>To show a greater apparent effect on gel mobility (C)</p> Signup and view all the answers

How are apoptotic nuclei detected in the image shown in the text?

<p>By adding a fluorescent label to DNA ends (C)</p> Signup and view all the answers

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