18 Questions
What is the main mechanism of action of Doxorubicin in inhibiting cancer cells?
Inhibiting DNA polymerase
How does Doxorubicin induce apoptosis in cancer cells?
Through activation of adenosine 5 monophosphate-activated protein kinase (AMPK)
What is the most serious long-term adverse effect of Doxorubicin therapy?
Irreversible cardiomyopathy
What role do increased levels of reactive oxygen species play in Doxorubicin-induced cardiomyopathy?
They result in apoptosis in the heart
How is Doxorubicin cardiomyopathy and other adverse effects mitigated?
Via liposomal drug delivery NPs
What is the group of agents that interfere with mitotic assembly of tubulin and induce cell death?
Tubulin assembly targeting drugs
What is one of the main reasons for the failure of chemotherapy in cancer treatment?
Multidrug resistance (MDR)
Name one mechanism of multidrug resistance (MDR) in cancer cells.
Increasing efflux of membrane transport proteins
How can drug targeting be altered in cancer cells to contribute to multidrug resistance?
Enhancing the DNA repair mechanism
What is one effective mechanism of resistance against commonly used anticancer drugs?
Modulation of membrane transport proteins
How can the intracellular accumulation of cytotoxic agents inside cancer cells be decreased?
By reducing drug uptake and/or increasing extrusion of the chemotherapeutic molecules
What are some factors that can influence the degree of block binding of nanoparticles to opsonins?
Thickness of the layer that coats the nanoparticles, coating strategies, PEG molecular weight, surface chain density, conformation
What is the role of P-glycoprotein (P-gp, MDR1, or ABCB1) in the development of MDR?
Overexpression of P-glycoprotein is responsible for the development of MDR (Multidrug Resistance).
How can inorganic nanoparticles (NPs) be used in drug delivery?
NPs can be used as drug cargos to transport and protect drugs, allowing high doses to arrive at specific locations.
What is the advantage of co-administering drugs and biomolecules with NPs?
Co-administration improves drug accumulation in tumors and unifies pharmacokinetic profiles, reducing drug degradation.
How can mesoporous silica nanoparticles be used in drug-resistant cancer cells?
NPs can deliver both doxorubicin and siRNA to increase drug sensitivity and intracellular drug concentration.
What is the mechanism of action of siRNA in drug-resistant cancer cells?
siRNA knocks down the gene expression of drug exporters to improve drug sensitivity to chemotherapeutic agents.
How does dual delivery of doxorubicin and siRNA improve drug concentration in drug-resistant cancer cells?
Dual delivery of doxorubicin and siRNA increases drug concentration intracellularly and in the nucleus to levels exceeding that of free doxorubicin.
Test your knowledge on Doxorubicin, a potent chemotherapeutic drug. Learn about its mechanism of action involving DNA polymerase, induction of apoptosis through AMPK activation, and long-term adverse effects like irreversible cardiomyopathy.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
